CAS Number5189-11-7
SynonymsSanomtgran; Sandomigran malate; Litec malate; Pizotyline malate; Pizotifen hydrogen malate; Pizotifen malate; Mosegor; Sandomygran malate; Sandomigran; Sandomigran,pizotyline
Molecular FormulaC23H27NO5S
Molecular Weight429.53
Purity98.00%
Boiling Point436.7ºC at 760 mmHg
Melting Point185-186° (dec)
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5189-11-7 |
| Catalog No. | 2A-9031515 |
| Chinese Name | 苯噻啶苹果酸盐 |
| Synonyms | Sanomtgran; Sandomigran malate; Litec malate; Pizotyline malate; Pizotifen hydrogen malate; Pizotifen malate; Mosegor; Sandomygran malate; Sandomigran; Sandomigran,pizotyline |
| Molecular Formula | C23H27NO5S |
| Molecular Weight | 429.53 |
| Purity | 98.00 |
| Boiling Point | 436.7ºC at 760 mmHg |
| Melting Point | 185-186° (dec) |
| Appearance | solid |
| Storage Condition | 2-8 °C |
| Application | Pizotifen malate is a potent antagonist of 5-HT2 receptors and has high affinity for 5-HT1C. |
| HTC | 2934999090 |
| MDL Number | MFCD01700978 |
| SMILES | [s]1c2c(cc1)C(=C4CCN(CC4)C)c3c(cccc3)CC2.OC(CC(=O)O)C(=O)O |
| InChI | 1S/C19H21NS.C4H6O5/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18;5-2(4(8)9)1-3(6)7/h2-5,10,13H,6-9,11-12H2,1H3;2,5H,1H2,(H,6,7)(H,8,9) |
| InChI Key | IWAWCPZVTXCFKD-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/31515_1_5189_11_7.pdf |
| Use of | Properties Name pizotifen malate Synonym More Synonyms Pizotifen malate Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease Natural Products >> Alkaloid 5-HT2A Receptor References [1]. Mylecharane EJ, et al. 5-HT2 receptor antagonists and migraine therapy. J Neurol. 1991;238 Suppl 1:S45-52. [2]. Lin OA, et al. The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. PLoS One. 2014 Jan 23;9(1):e87026. [3]. Ujházy E, et al. Teratological and cytogenetical evaluation of two antihistamines (pipethiadene and pizotifen maleate) in mice. Agents Actions. 1988 Apr;23(3-4):376-8. Chemical & Physical Properties Molecular Formula C23H27NO5S PSA 106.08000 LogP 4.02390 InChIKey IWAWCPZVTXCFKD-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C19-H21-N-S.C4-H6-O5 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T C576 BY FS&T&J BU- DT6N DYTJ A1 &QV1U1VQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - visual field changes Cardiac - pulse rate increase, without fall in BP Nutritional and Gross Metabolic - body temperature increase REFERENCE : PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 63,59,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 19,19,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 19,19,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 19,19,1969 Safety Information Hazard Codes Xi HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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