CAS Number5154-02-9
Synonymsisoquinoline-1,5-diol; 5-Hydroxyisocarbostyril; 5-Hydroxy-1(2H)-isoquinolinone; 5-Hydroxyisoquinoline-1(2H)-one; 1,5-Dihydroxyisoquinoline 5-Hydroxy-1(2H)-isoquinolinone DiQ; 5-hydroxy-2H-isoquinolin-1-one; MFCD00006900; 5-Hydroxyisoquinolin-1(2H)-one; 1,5-Isoquinolinediol
Molecular FormulaC9H7NO2
Molecular Weight161.157
Purity98.00%
Density1.4±0.1 g/cm3
Boiling Point501.1±30.0 °C at 760 mmHg
Melting Point270-275 °C
AppearanceWhite to white powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5154-02-9 |
| Catalog No. | 2A-9031490 |
| Chinese Name | 1,5-二羟基异喹啉 |
| Synonyms | isoquinoline-1,5-diol; 5-Hydroxyisocarbostyril; 5-Hydroxy-1(2H)-isoquinolinone; 5-Hydroxyisoquinoline-1(2H)-one; 1,5-Dihydroxyisoquinoline 5-Hydroxy-1(2H)-isoquinolinone DiQ; 5-hydroxy-2H-isoquinolin-1-one; MFCD00006900; 5-Hydroxyisoquinolin-1(2H)-one; 1,5-Isoquinolinediol |
| Molecular Formula | C9H7NO2 |
| Molecular Weight | 161.157 |
| Purity | 98.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 501.1±30.0 °C at 760 mmHg |
| Melting Point | 270-275 °C |
| Appearance | White to white powder |
| Water Solubility | DMSO: >36 mg/mL |
| Storage Condition | 2-8°C |
| Application | 1,5-Isoquinolinediol is a potent PARP inhibitor with IC50 values of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced oxidative stress induced by retinal NADPH oxidase. |
| HTC | 2933499090 |
| SMILES | O=c1[nH]ccc2c(O)cccc12 |
| InChI Key | LFUJIPVWTMGYDG-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | 1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina[1][2]. Related Catalog Signaling Pathways >> Epigenetics >> PARP Research Areas >> Metabolic Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PARP Target PARP:0.18-0.37 μM (IC50) In Vitro 1,5-isoquinolinediol leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene[1]. 1,5-Isoquinolinediol is a potent PARP antagonist and decreases cleaved PARP in diabetic retina.1,5-Isoquinolinediol (500 μM H2O2; 24 hours) attenuates H2O2-induced upregulation of cleaved PARP-1 expression in retinal Muller cells. 1,5-Isoquinolinediol attenuates diabetes-induced upregulation of retinal nitrated protein expression. 1,5-Isoquinolinediol attenuates diabetes-induced activation of NADPH oxidase in the retina[2]. References [1]. Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2019 Dec 9. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 501.1±30.0 °C at 760 mmHg Melting Point 270-275 °C Molecular Formula C9H7NO2 Molecular Weight 161.157 Flash Point 256.8±24.6 °C Exact Mass 161.047684 PSA 53.35000 LogP -0.17 Vapour Pressure 0.0±1.3 mmHg at 25°C Index of Refraction 1.743 InChIKey LFUJIPVWTMGYDG-UHFFFAOYSA-N SMILES O=c1[nH]ccc2c(O)cccc12 Storage condition 2-8°C Water Solubility DMSO: >36 mg/mL |
| Use of | 1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina[1][2]. Properties Articles23 Name isoquinoline-1,5-diol Synonym More Synonyms 1,5-Isoquinolinediol Biological Activity Description 1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina[1][2]. Related Catalog Signaling Pathways >> Epigenetics >> PARP Research Areas >> Metabolic Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PARP PARP:0.18-0.37 μM (IC50) In Vitro 1,5-isoquinolinediol leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene[1]. 1,5-Isoquinolinediol is a potent PARP antagonist and decreases cleaved PARP in diabetic retina.1,5-Isoquinolinediol (500 μM H2O2; 24 hours) attenuates H2O2-induced upregulation of cleaved PARP-1 expression in retinal Muller cells. 1,5-Isoquinolinediol attenuates diabetes-induced upregulation of retinal nitrated protein expression. 1,5-Isoquinolinediol attenuates diabetes-induced activation of NADPH oxidase in the retina[2]. References [1]. Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2019 Dec 9. Chemical & Physical Properties Molecular Formula C9H7NO2 Exact Mass 161.047684 PSA 53.35000 LogP -0.17 Index of Refraction 1.743 InChIKey LFUJIPVWTMGYDG-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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