CAS Number5108-96-3
Synonyms1-Pyrrolidinecarbodithioic acid,ammonium salt; EINECS 225-834-4; Pyrrolindinedithiocarbamate ammonium; 1-Pyrrolidinecarbodithioic acid ammoniate (1:1); Ammonium Pyrrolidine-N-dithiocarbamate; ammonium tetramethylenedithiocarbamate; Pyrrolidine-N-dithiocarbamic Acid Ammonium Salt; Ammonium 1-pyrrolidinedithiocarboxylate; APDTC AMMONIUM SALT; Ammonium pyrrolidinecarbodithioate; MFCD00012720; APCD; PDTC,NH4; PYRROLIDINEDITHIOCARBAMATE; APDTC; 1-PYRROLIDINECARBODITHIOIC ACID AMMONIUM SALT; pyrrolidine-1-dithiocarboxylic acid ammonium salt; Ammonium pyrrolidine; 1-Pyrrolidinecarbodithioic acid, ammonuim salt; Ammonium pyrrolidine dithiocarbamate; Pyrrolidinedithiocarbamic acid ammonium salt; APDC; Ammonium 1-Pyrrolidinecarbodithioate; 1-PYRROLIDINECARBODITHIOIC ACID; Pyrrolidinedithiocarbamate
Molecular FormulaC5H9NS2 · NH3
Molecular Weight164.29
Purity~99%
Density1.264g/cm3
Boiling Point199.7ºC at 760 mmHg
Melting Point153-155 °C (lit.)
Appearance(powderor powder with lumps)
EINECS225-834-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5108-96-3 |
| Catalog No. | 2A-9031448 |
| Chinese Name | 吡咯烷二硫代甲酸铵 |
| Synonyms | 1-Pyrrolidinecarbodithioic acid,ammonium salt; EINECS 225-834-4; Pyrrolindinedithiocarbamate ammonium; 1-Pyrrolidinecarbodithioic acid ammoniate (1:1); Ammonium Pyrrolidine-N-dithiocarbamate; ammonium tetramethylenedithiocarbamate; Pyrrolidine-N-dithiocarbamic Acid Ammonium Salt; Ammonium 1-pyrrolidinedithiocarboxylate; APDTC AMMONIUM SALT; Ammonium pyrrolidinecarbodithioate; MFCD00012720; APCD; PDTC,NH4; PYRROLIDINEDITHIOCARBAMATE; APDTC; 1-PYRROLIDINECARBODITHIOIC ACID AMMONIUM SALT; pyrrolidine-1-dithiocarboxylic acid ammonium salt; Ammonium pyrrolidine; 1-Pyrrolidinecarbodithioic acid, ammonuim salt; Ammonium pyrrolidine dithiocarbamate; Pyrrolidinedithiocarbamic acid ammonium salt; APDC; Ammonium 1-Pyrrolidinecarbodithioate; 1-PYRROLIDINECARBODITHIOIC ACID; Pyrrolidinedithiocarbamate |
| Molecular Formula | C5H9NS2 · NH3 |
| Molecular Weight | 164.29 |
| Purity | ~99 |
| Density | 1.264g/cm3 |
| Boiling Point | 199.7ºC at 760 mmHg |
| Melting Point | 153-155 °C (lit.) |
| Appearance | (powderor powder with lumps) |
| Water Solubility | 50 g/L (20 ºC) |
| Storage Condition | This product should be sealed and stored in a cool |
| Application | Pyrrolidinedithiocarbamate ammonium is a selective NF-κB inhibitor. |
| EINECS | 225-834-4 |
| HTC | 29339990 |
| PubChem ID | 24278658 |
| MDL Number | MFCD00012720 |
| SMILES | N.SC(=S)N1CCCC1 |
| InChI | 1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3 |
| InChI Key | MDDIUTVUBYEEEM-UHFFFAOYSA-N |
| Beilstein/REAXYS | 3730472 |
| NACRES Code | NA.77 |
| UNSPSC | 12352107 |
| Hazard Symbols | transportation |
| MSDS | msds/31448_1_5108_96_3.pdf |
| Bioactivity | Pyrrolidinedithiocarbamate ammonium is a selective NF-κB inhibitor. Related Catalog Signaling Pathways >> NF-κB >> NF-κB Research Areas >> Cancer Target NF-κB In Vitro Pretreatment of cells with pyrrolidinedithiocarbamate (3-1000 μM) dose-dependently attenuate IL-8 production. Furthermore, pyrrolidinedithiocarbamate (100 μM) suppresses the accumulation of IL-8 mRNA. Pyrrolidinedithiocarbamate inhibits the activation of NF-κB, because pyrrolidinedithiocarbamate suppresses both NF-κB DNA binding and NF-κB-dependent transcriptional activity. NF-κB inhibition with pyrrolidinedithiocarbamate decrease IL-8 production by intestinal epithelial cells[1]. In Vivo The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis[2]. Cell Assay The human colon cancer cell line HT-29 is obtained and cells are grown in modified McCoy's 5A medium supplemented with 10% fetal bovine serum. To study the effect of pyrrolidinedithiocarbamate ammonium on IL-8 production, HT-29 cells in 96-well plates are induced with 20 ng/mL of IL-1β for 18 h. Various concentrations (3-1000 μM) of pyrrolidinedithiocarbamate or its vehicle (culture medium) are added to the cells 30 min prior to IL-1β stimulation. The concentration of IL-8 in the supernatant is determined using solid-phase enzyme-linked immunosorbent assay[1]. Animal Admin Animal Administration: [2]Pyrrolidinedithiocarbamate is administered intraperitoneally to mice at dose levels of 100 and 50 mg/kg. Mice are divided into a DSS-untreated group (normal group), DSS-treated control group, DSS+pyrrolidinedithiocarbamate-treated groupI (low-dose group), and DSS+pyrrolidinedithiocarbamate-treated groupII (high-dose group). In each group, the disease activity index score (DAI score), intestinal length, histological score, and the levels of activated NF-κB and inflammatory cytokines (IL-1β and TNF-α) in tissue are measured[2]. References [1]. Németh ZH, et al. Pyrrolidinedithiocarbamate inhibits NF-kappaB activation and IL-8 production in intestinal epithelial cells. Immunol Lett. 2003 Jan 2;85(1):41-6. [2]. Qin JD, et al. Effect of ammonium pyrrolidine dithiocarbamate (PDTC) on NF-κB activation and CYP2E1 content of rats with immunological liver injury. Pharm Biol. 2014 Nov;52(11):1460-1466. Chemical & Physical Properties Density 1.264g/cm3 Boiling Point 199.7ºC at 760 mmHg Melting Point 153-155 °C(lit.) Molecular Formula C5H12N2S2 Molecular Weight 164.292 Flash Point 74.6ºC Exact Mass 164.044189 PSA 77.37000 LogP 1.55870 InChIKey VSWDORGPIHIGNW-UHFFFAOYSA-M SMILES S=C([S-])N1CCCC1 Storage condition 2-8°C Stability Stable. Incompatible with strong oxidizing agents. Water Solubility 50 g/L (20 ºC) |
| Use of | Pyrrolidinedithiocarbamate ammonium is a selective NF-κB inhibitor. Properties Articles53 Name Ammonium 1-pyrrolidinedithiocarbamate Synonym More Synonyms Ammonium 1-pyrrolidinedithiocarbamate Biological Activity Description Pyrrolidinedithiocarbamate ammonium is a selective NF-κB inhibitor. Related Catalog Signaling Pathways >> NF-κB >> NF-κB Research Areas >> Cancer In Vivo The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis[2]. References [1]. Németh ZH, et al. Pyrrolidinedithiocarbamate inhibits NF-kappaB activation and IL-8 production in intestinal epithelial cells. Immunol Lett. 2003 Jan 2;85(1):41-6. Chemical & Physical Properties Molecular Formula C5H12N2S2 Exact Mass 164.044189 PSA 77.37000 LogP 1.55870 InChIKey VSWDORGPIHIGNW-UHFFFAOYSA-M Stability Stable. Incompatible with strong oxidizing agents. |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 95.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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