CAS Number5053-06-5
Synonyms8-phenethyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one; Fluiden; Fenspiridum [INN-Latin]; Fenspiride [INN]; EINECS 225-751-3; Viarespan; 8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one; Fenspiride; Respiride; Fenspirida [INN-Spanish]
Molecular FormulaC15H21O2N2Cl1
Molecular Weight296.8
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point408.3±55.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5053-06-5 |
| Catalog No. | 2A-9031409 |
| Chinese Name | 芬司匹利 |
| Synonyms | 8-phenethyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one; Fluiden; Fenspiridum [INN-Latin]; Fenspiride [INN]; EINECS 225-751-3; Viarespan; 8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one; Fenspiride; Respiride; Fenspirida [INN-Spanish] |
| Molecular Formula | C15H21O2N2Cl1 |
| Molecular Weight | 296.8 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 408.3±55.0 °C at 760 mmHg |
| Application | The nonsteroidal anti-inflammatory drug fenspiramate is an antagonist of H1 histamine receptors. Fenspiracyclate inhibits the activities of phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and p |
| HTC | 2934999090 |
| MDL Number | MFCD00133315 |
| SMILES | O=C1NCC2(CCN(CCc3ccccc3)CC2)O1 |
| InChI | InChI=1S/C15H20N2O2/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13/h1-5H,6-12H2,(H,16,18) |
| InChI Key | FVNFBBAOMBJTST-UHFFFAOYSA-N |
| MSDS | msds/31409_1_5053_06_5.pdf |
| Use of | Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases[1][2][3]. Properties Name 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one Synonym More Synonyms Fenspiride Biological Activity Description Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases[1][2][3]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor -log IC50: 3.44 (PDE3); 4.16 (PDE4); approximately 3.8 (PDE5)[2] In Vitro Fenspiride (around 100 μM) inhibits histamine-induced contraction of isolated guinea pig trachea[2]. Fenspiride (≤1000 μM) produces less than 25% inhibition of phosphodiesterase 1 and phosphodiesterase 2 activities[2]. References [1]. Matuszewska A, et al. Long-term administration of fenspiride has no negative impact on bone mineral density and bone turnover in young growing rats. Adv Clin Exp Med. 2019 Jun;28(6):771-776. [2]. Cortijo J, et al. Effects of fenspiride on human bronchial cyclic nucleotide phosphodiesterase isoenzymes: functional and biochemical study. Eur J Pharmacol. 1998 Jan 2;341(1):79-86. [3]. De Castro CM, et al. Fenspiride: an anti-inflammatory drug with potential benefits in the treatment of endotoxemia. Eur J Pharmacol. 1995 Dec 29;294(2-3):669-76. Chemical & Physical Properties Molecular Formula C15H20N2O2 Exact Mass 260.152466 PSA 41.57000 Index of Refraction 1.609 InChIKey FVNFBBAOMBJTST-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-phenethyl- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C15-H20-N2-O2 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T6N CXTJ A2R& C-& DT5MVOX EHJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 4,185,1969 Safety Information HS Code 2934999090 Synthetic Route Triphosgene CAS#:32315-10-9 4-(aminomethyl)... CAS#:23808-42-6 Fenspiride CAS#:5053-06-5 Literature: Somanathan; Rivero; Nunez; Hellberg Synthetic Communications, 1994 , vol. 24, # 10 p. 1483 - 1487 1-Phenethyl-4-p... CAS#:39742-60-4 Fenspiride CAS#:5053-06-5 Literature: Synthetic Communications, , vol. 24, # 10 p. 1483 - 1487 1-(2-phenethyl)... CAS#:156215-50-8 Fenspiride CAS#:5053-06-5 Literature: Synthetic Communications, , vol. 24, # 10 p. 1483 - 1487 Precursor & DownStream Precursor 4 CAS#:32315-10-9 Triphosgene CAS#:23808-42-6 4-(aminomethyl)... CAS#:39742-60-4 1-Phenethyl-4-p... CAS#:105-58-8 Ethyl carbonate DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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