CAS Number4546-54-7
Synonyms9H-purine, 2-amino-9-β-d-ribofuranosyl-,; 9-(β-D-Ribofuranosyl)-9H-purin-2-amine; 2-amino-9-(β-D-ribofuranosyl)purine; 2-(2-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Molecular FormulaC10H13N5O4
Molecular Weight251.24
Purity98.00%
Density2.1±0.1 g/cm3
Boiling Point711.8±70.0 °C at 760 mmHg
Melting Point105-115ºC
AppearanceOff-white crystalline solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 4546-54-7 |
| Catalog No. | 2A-9031014 |
| Chinese Name | 2-氨基嘌呤核苷 |
| Synonyms | 9H-purine, 2-amino-9-β-d-ribofuranosyl-,; 9-(β-D-Ribofuranosyl)-9H-purin-2-amine; 2-amino-9-(β-D-ribofuranosyl)purine; 2-(2-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol |
| Molecular Formula | C10H13N5O4 |
| Molecular Weight | 251.24 |
| Purity | 98.00 |
| Density | 2.1±0.1 g/cm3 |
| Boiling Point | 711.8±70.0 °C at 760 mmHg |
| Melting Point | 105-115ºC |
| Appearance | Off-white crystalline solid |
| Application | (2R,3R,4S,5R)-2-(2-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (9-furopentyl-9H-purin-2-amine) is a purine nucleoside analog. Purine nucleoside analogues have broad antitumor activi |
| HTC | 2933599090 |
| MDL Number | C10H13N5O3 |
| SMILES | Nc1ncc2ncn(C3OC(CO)C(O)C3O)c2n1 |
| InChI | InChI=1S/C10H13N5O4/c11-10-12-1-4-8(14-10)15(3-13-4)9-7(18)6(17)5(2-16)19-9/h1,3,5-7,9,16-18H,2H2,(H2,11,12,14) |
| InChI Key | JVOJULURLCZUDE-SZDPNDIZSA-N |
| MSDS | msds/31014_1_4546_54_7.pdf |
| Use of | (2R,3R,4S,5R)-2-(2-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (9-pentofuranosyl-9H-purin-2-amine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. Properties Name 2-Aminopurine Riboside Synonym More Synonyms 2-amino-9-(β-D-ribofuranosyl)purine Biological Activity Description (2R,3R,4S,5R)-2-(2-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (9-pentofuranosyl-9H-purin-2-amine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others References [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. Chemical & Physical Properties Molecular Formula C10H13N5O4 Exact Mass 267.096741 PSA 139.54000 LogP -1.40 Index of Refraction 1.907 InChIKey JVOJULURLCZUDE-SZDPNDIZSA-N SMILES Nc1ncc2ncn(C3OC(CO)C(O)C3O)c2n1 Safety Information HS Code 2933599090 Synthetic Route 2-amino-9-(2,3,... 107037-21-8 2-amino-9-(&bet... Literature: Nair; Young; DeSilvia Jr. Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1344 - 1347 6-Thioguanosine 2-amino-9-(&bet... Literature: Doudna, Jennifer A.; Szostak, Jack W.; Rich, Alexander; Usman, Nassim Journal of Organic Chemistry, 1990 , vol. 55, # 21 p. 5547 - 5549 2-benzoylamidop... 100122-98-3 2-amino-9-(&bet... Literature: Schaeffer; Thomas Journal of the American Chemical Society, 1958 , vol. 80, p. 4896,4898 Precursor & DownStream Precursor 9 CAS#:107037-21-8 2-amino-9-(2,3,... CAS#:85-31-4 6-Thioguanosine CAS#:100122-98-3 2-benzoylamidopurine CAS#:6974-32-9 b-D-Ribofuranos... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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