CAS Number4233-96-9
Synonyms(−)-Gallocatechin gallate; (-)-Gallocatechin gallate; Gallocatechin gallate; MFCD00214298; GCG; (-)-Gallocatechin 3-O-gallate
Molecular FormulaC22H18O11
Molecular Weight458.37
Purity≥98 (HPLC)%
Density1.9±0.1 g/cm3
Boiling Point909.1±65.0 °C at 760 mmHg
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 4233-96-9 |
| Catalog No. | 2A-9030685 |
| Chinese Name | 没食子儿茶素没食子酸酯 |
| Synonyms | (−)-Gallocatechin gallate; (-)-Gallocatechin gallate; Gallocatechin gallate; MFCD00214298; GCG; (-)-Gallocatechin 3-O-gallate |
| Molecular Formula | C22H18O11 |
| Molecular Weight | 458.37 |
| Purity | ≥98 (HPLC) |
| Density | 1.9±0.1 g/cm3 |
| Boiling Point | 909.1±65.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | 2-8℃, avoid light, ventilated and dry place, seale |
| Application | (-)-Gallocatechin gallate is a polyphenol in tea that has anti-cancer effects. |
| PubChem ID | 24895275 |
| MDL Number | MFCD00214298 |
| SMILES | Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H](Oc2c1)c4cc(O)c(O)c(O)c4 |
| InChI | 1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21+/m1/s1 |
| InChI Key | WMBWREPUVVBILR-NQIIRXRSSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/30685_1_4233_96_9.pdf |
| Bioactivity | (-)-Gallocatechin gallate is the polyphenol isolated from tea, with cancer-preventive activities. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Flavonoids In Vitro The amount of (-)-Gallocatechin gallate does not differ in leaves of different stages, and the content is relatively low[1]. (−)-gallocatechin gallate in combination with active catechins ((−)-epigallocatechin gallate) has synergistic effects on the induction of apoptosis and inhibition of cell growth for PC-9 cells. (−)-gallocatechin gallate shows inhibitory effect on α-Glucosidase and DPPH, with IC50s of 30.2 μM and 12.2 μg/mL[2]. Cell Assay Cell viability is examined by measuring the capability of cells to metabolize MTT to a purple formazan dye. Human liver cancer HepG2 cells are maintained in DMEM medium supplemented with 10% fetal bovine serum, 100 units/mL penicillin, and 50 units/mL streptomycin at 37°C in a humidified incubator with 5% CO2 atmosphere. Cells are seeded in 96-well tissue culture plates for 24 h and then incubated with the tested compounds at different concentrations for 72 h. After incubation, 25 μL MTT in 5 mg/mL PBS is added and incubated for 4 h. The medium is aspirated and replaced with 150 μL dimethyl sulfoxide (DMSO) to dissolve the formazan salt. The color intensity of the formazan solution, which reflects the cell growth condition, is measured at 570 nm using a microplate spectrophotometer. References [1]. Zhang LQ, et al. Accumulation of catechins and expression of catechin synthetic genes in Camellia sinensis at different developmental stages. Bot Stud. 2016 Dec;57(1):31. [2]. Zhou H, et al. C-geranylated flavanones from YingDe black tea and their antioxidant and α-glucosidase inhibition activities. Food Chem. 2017 Nov 15;235:227-233. Chemical & Physical Properties Density 1.9±0.1 g/cm3 Boiling Point 909.1±65.0 °C at 760 mmHg Molecular Formula C22H18O11 Molecular Weight 458.372 Flash Point 320.0±27.8 °C Exact Mass 458.084900 PSA 197.37000 LogP 2.08 Vapour Pressure 0.0±0.3 mmHg at 25°C Index of Refraction 1.857 InChIKey WMBWREPUVVBILR-NQIIRXRSSA-N SMILES O=C(OC1Cc2c(O)cc(O)cc2OC1c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1 Storage condition 2-8°C |
| Use of | (-)-Gallocatechin gallate is the polyphenol isolated from tea, with cancer-preventive activities. Properties Articles11 Name (-)-Gallocatechin gallate Synonym More Synonyms (-)-Gallocatechin gallate Biological Activity Description (-)-Gallocatechin gallate is the polyphenol isolated from tea, with cancer-preventive activities. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Flavonoids References [1]. Zhang LQ, et al. Accumulation of catechins and expression of catechin synthetic genes in Camellia sinensis at different developmental stages. Bot Stud. 2016 Dec;57(1):31. [2]. Zhou H, et al. C-geranylated flavanones from YingDe black tea and their antioxidant and α-glucosidase inhibition activities. Food Chem. 2017 Nov 15;235:227-233. Chemical & Physical Properties Molecular Formula C22H18O11 Exact Mass 458.084900 PSA 197.37000 Index of Refraction 1.857 InChIKey WMBWREPUVVBILR-NQIIRXRSSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip. |
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