CAS Number4199-88-6
Synonyms5-nitro-1,10-phenenthroline; 5-Nitro-1,10-phenanthroline; 5-Nitro-1,10-diazaphenanthrene; EINECS 224-097-6; 5-nitro-1,10-phenantroline; 1,10-Phenanthroline,5-nitro; Nitroferroin; MFCD00004981
Molecular FormulaC12H7N3O2
Molecular Weight225.20
Purity≥97%
Density1.4±0.1 g/cm3
Boiling Point444.0±30.0 °C at 760 mmHg
Melting Point202-204 °C (lit.)
Appearancecrystalline
EINECS224-097-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 4199-88-6 |
| Catalog No. | 2A-9030653 |
| Chinese Name | 5-硝基-1,10-菲咯啉 |
| Synonyms | 5-nitro-1,10-phenenthroline; 5-Nitro-1,10-phenanthroline; 5-Nitro-1,10-diazaphenanthrene; EINECS 224-097-6; 5-nitro-1,10-phenantroline; 1,10-Phenanthroline,5-nitro; Nitroferroin; MFCD00004981 |
| Molecular Formula | C12H7N3O2 |
| Molecular Weight | 225.20 |
| Purity | ≥97 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 444.0±30.0 °C at 760 mmHg |
| Melting Point | 202-204 °C (lit.) |
| Appearance | crystalline |
| Water Solubility | insoluble |
| Storage Condition | Keep away from light, in a ventilated and dry plac |
| Application | 5-Nitro-1,10-phenanthroline (5-NP) is an o-phenanthroline (HY-W004544) derivative, which acts as a mediator of glucose oxidase (GOX) with anti-tuberculosis activity. 5-nitro-1,10-phenanthroline can be |
| EINECS | 224-097-6 |
| HTC | 2933990090 |
| PubChem ID | 24897678 |
| MDL Number | MFCD00004981 |
| SMILES | [O-][N+](=O)c1cc2cccnc2c3ncccc13 |
| InChI | 1S/C12H7N3O2/c16-15(17)10-7-8-3-1-5-13-11(8)12-9(10)4-2-6-14-12/h1-7H |
| InChI Key | PDDBTWXLNJNICS-UHFFFAOYSA-N |
| Beilstein/REAXYS | 196245 |
| NACRES Code | NA.77 |
| UNSPSC | 12352202 |
| Hazard Symbols | transportation |
| MSDS | msds/30653_1_4199_88_6.pdf |
| Bioactivity | 5-Nitro-1,10-phenanthroline (5-NP), is a o-Phenanthroline (HY-W004544) derivative, as a mediator of glucose oxidase (GOX) with antituberculous activity. 5-Nitro-1,10-phenanthroline can be applied as redox mediators for oxidases and is suitable for the development of reagent-less biosensors and biofuel cells[1][1]. Related Catalog Research Areas >> Infection In Vitro 5-Nitro-1,10-phenanthroline (25 μM; 24 h) kills naturally resistant intracellular bacteria by inducing autophagy in THP-1 macrophages[2]. 5-Nitro-1,10-phenanthroline (1x, 5x, 20x or 50x MIC, MIC=0.78 μM; 1 h) also modulates the host machinery to kill intracellular pathogens by inhibiting mycolic acid biosynthesis of Mtb[2]. Cell Viability Assay[2] Cell Line: Mtb H37Rv, M. bovis BCG and M. bovis BCG-5NP resistant strain Concentration: 0-12.5 μM Incubation Time: 24 hours Result: Inhibited pathogens with MIC99 values of 0.78 μM (Mtb H37Rv), 0.78 μM (M. bovis BCG), and >12.5 μM (M. bovis BCG-5NP), respectively. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 444.0±30.0 °C at 760 mmHg Melting Point 202-204 °C(lit.) Molecular Formula C12H7N3O2 Molecular Weight 225.203 Flash Point 222.3±24.6 °C Exact Mass 225.053833 PSA 71.60000 LogP 1.56 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.768 InChIKey PDDBTWXLNJNICS-UHFFFAOYSA-N SMILES O=[N+]([O-])c1cc2cccnc2c2ncccc12 Water Solubility insoluble |
| Use of | 5-Nitro-1,10-phenanthroline (5-NP), is a o-Phenanthroline (HY-W004544) derivative, as a mediator of glucose oxidase (GOX) with antituberculous activity. 5-Nitro-1,10-phenanthroline can be applied as redox mediators for oxidases and is suitable for the development of reagent-less biosensors and biofuel cells[1][1]. Properties Name 5-Nitro-1,10-phenanthroline Synonym More Synonyms 5-Nitro-1,10-phenanthroline Biological Activity Description 5-Nitro-1,10-phenanthroline (5-NP), is a o-Phenanthroline (HY-W004544) derivative, as a mediator of glucose oxidase (GOX) with antituberculous activity. 5-Nitro-1,10-phenanthroline can be applied as redox mediators for oxidases and is suitable for the development of reagent-less biosensors and biofuel cells[1][1]. Related Catalog Research Areas >> Infection Chemical & Physical Properties Molecular Formula C12H7N3O2 Exact Mass 225.053833 PSA 71.60000 Index of Refraction 1.768 InChIKey PDDBTWXLNJNICS-UHFFFAOYSA-N Water Solubility insoluble |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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