CAS Number4085-31-8
Synonyms4,4'-(propane-1,3-diyldipiperazine-4,1-diyl)bis(7-chloroquinoline); Piperaquine tetraphosphate tetrahydrate; 7-Chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline; Piperaquine; piperaquinoline; PIRERAQUINE PHOSPHATE; 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline)
Molecular FormulaC29H32Cl2N6
Molecular Weight999.55
Purity≥98 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point721.1±60.0 °C at 760 mmHg
Melting Point198-200°C (lit.)
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 4085-31-8 |
| Catalog No. | 2A-9030532 |
| Chinese Name | 磷酸哌喹 |
| Synonyms | 4,4'-(propane-1,3-diyldipiperazine-4,1-diyl)bis(7-chloroquinoline); Piperaquine tetraphosphate tetrahydrate; 7-Chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline; Piperaquine; piperaquinoline; PIRERAQUINE PHOSPHATE; 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) |
| Molecular Formula | C29H32Cl2N6 |
| Molecular Weight | 999.55 |
| Purity | ≥98 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 721.1±60.0 °C at 760 mmHg |
| Melting Point | 198-200°C (lit.) |
| Appearance | powder |
| Storage Condition | room temperature |
| Application | Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in combination with artemisinin for antimalarial research [1][2]. |
| HTC | 2942000000 |
| PubChem ID | 329775155 |
| MDL Number | MFCD11870901 |
| SMILES | O.O.O.O.OP(O)(O)=O.OP(O)(O)=O.OP(O)(O)=O.OP(O)(O)=O.Clc1ccc2c(ccnc2c1)N3CCN(CCCN4CCN(CC4)c5ccnc6cc(Cl)ccc56)CC3 |
| InChI | 1S/C29H32Cl2N6.4H3O4P.4H2O/c30-22-2-4-24-26(20-22)32-8-6-28(24)36-16-12-34(13-17-36)10-1-11-35-14-18-37(19-15-35)29-7-9-33-27-21-23(31)3-5-25(27)29;4*1-5(2,3)4;;;;/h2-9,20-21H,1,10-19H2;4*(H3,1,2,3,4);4*1H2 |
| InChI Key | AMCQDGFOKTXHSY-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/30532_1_4085_31_8.pdf |
| Use of | Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin[1][2]. Properties Name Piperaquine phosphate Synonym More Synonyms piperaquine phosphate Biological Activity Description Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin[1][2]. Related Catalog Research Areas >> Infection References [1]. Moore BR, et, al. Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model. Antimicrob Agents Chemother. 2008 Jan; 52(1): 306-11. [2]. Davis TME, et, al. Piperaquine: a resurgent antimalarial drug. Drugs. 2005; 65(1): 75-87. Chemical & Physical Properties Exact Mass 534.206543 PSA 38.74000 Index of Refraction 1.664 InChIKey UCRHFBCYFMIWHC-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Quinoline, 4,4'-(trimethylenedi-4,1-piperazinediyl)bis(7-chloro- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C29-H32-Cl2-N6 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,273,1986 Safety Information Hazard Codes Xi HS Code 2942000000 Precursor & DownStream Precursor 3 CAS#:109-64-8 1,3-Dibromopropane CAS#:837-52-5 7-Chloro-4-(pip... CAS#:86-98-6 4,7-Dichloroqui... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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