CAS Number14080-23-0
Synonyms2-Cyanopyrimidine; NaMe: 2-CyanopyriMidine; Pyrimidin-2-carbonitril; 2-Cynopyrimidine; 2-CPY; pyrimidin-2-carbonitrile; MFCD00160513; 2-Pyrimidinecarbonitrile; Pyrimidine-2-carbonitrile; 2-cyanpyrimidine; 2-pyrimidinenitrile
Molecular FormulaC5H3N3
Molecular Weight105.10
Purity97%
Density1.2±0.1 g/cm3
Boiling Point250.7±23.0 °C at 760 mmHg
Melting Point40-44 °C (lit.)
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 14080-23-0 |
| Catalog No. | 2A-9003045 |
| Chinese Name | 2-氰基嘧啶 |
| Synonyms | 2-Cyanopyrimidine; NaMe: 2-CyanopyriMidine; Pyrimidin-2-carbonitril; 2-Cynopyrimidine; 2-CPY; pyrimidin-2-carbonitrile; MFCD00160513; 2-Pyrimidinecarbonitrile; Pyrimidine-2-carbonitrile; 2-cyanpyrimidine; 2-pyrimidinenitrile |
| Molecular Formula | C5H3N3 |
| Molecular Weight | 105.10 |
| Purity | 97 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 250.7±23.0 °C at 760 mmHg |
| Melting Point | 40-44 °C (lit.) |
| Appearance | solid |
| Water Solubility | Soluble in: methanol |
| Storage Condition | Room Temperature |
| Application | 2-Cyanopyrimidine is a potent, non-selective inhibitor of the cysteine protease cathepsin K with an IC50 of 170 nM. 2-Cyanopyrimidine is used in osteoporosis. |
| HTC | 2933599090 |
| PubChem ID | 24883490 |
| MDL Number | MFCD00160513 |
| SMILES | N#Cc1ncccn1 |
| InChI | 1S/C5H3N3/c6-4-5-7-2-1-3-8-5/h1-3H |
| InChI Key | IIHQNAXFIODVDU-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| MSDS | msds/3045_1_14080_23_0.pdf |
| Bioactivity | 2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos[1]. Related Catalog Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin Target IC50: 170 nM (cysteine protease cathepsin K)[1] In Vitro 2-Cyanopyrimidine is a 2-cyano-4-cyclohexylamino-pyrimidine derivative. Cathepsin K is a lysosomal cysteine protease[1]. References [1]. Altmann E, et al. 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem. 2007 Feb 22;50(4):591-4. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 250.7±23.0 °C at 760 mmHg Melting Point 40-44 °C(lit.) Molecular Formula C5H3N3 Molecular Weight 105.097 Flash Point 97.2±7.8 °C Exact Mass 105.032700 PSA 49.57000 LogP -0.31 Vapour Pressure 0.0±0.5 mmHg at 25°C Index of Refraction 1.541 InChIKey IIHQNAXFIODVDU-UHFFFAOYSA-N SMILES N#Cc1ncccn1 |
| Use of | 2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos[1]. Properties Name 2-Cyanopyrimidine Synonym More Synonyms 2-Cyanopyrimidine Biological Activity Description 2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor with an IC50 of 170 nM. 2-Cyanopyrimidine is used for osteoporos[1]. Related Catalog Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin IC50: 170 nM (cysteine protease cathepsin K)[1] In Vitro 2-Cyanopyrimidine is a 2-cyano-4-cyclohexylamino-pyrimidine derivative. Cathepsin K is a lysosomal cysteine protease[1]. References [1]. Altmann E, et al. 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem. 2007 Feb 22;50(4):591-4. Chemical & Physical Properties Molecular Formula C5H3N3 Exact Mass 105.032700 PSA 49.57000 LogP -0.31 Index of Refraction 1.541 InChIKey IIHQNAXFIODVDU-UHFFFAOYSA-N SMILES N#Cc1ncccn1 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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