![6,11-Dihydro-11-(1-methyl-4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine structure, CAS 3964-81-6](/structures/40000/30339_1_3964_81_6.png)
CAS Number3964-81-6
Synonyms11-(1-methyl-piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; Azatadinum [INN-Latin]; Azatadina [INN-Spanish]; 11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[3,4-b]pyridine; Azatadina; Optimine; Azatadinum; Azatidine; Azatadine [INN:BAN]; 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 6,11--dihydro-11-(N-methyl-4-piperidylidene)-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine; Azatadine maleate; Zadine; AZATADINE
Molecular FormulaC28H30O8N2
Molecular Weight522.55
Purity98.00%
Density1.127 g/cm3
Boiling Point450.1ºC at 760 mmHg
Melting Point124-126ºC
AppearanceWhite or off-white crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 3964-81-6 |
| Catalog No. | 2A-9030339 |
| Chinese Name | 6,11-二氢-11-(1-甲基-4-哌啶亚基)-5H-苯并[5,6]环庚烷并[1,2-b]吡啶 |
| Synonyms | 11-(1-methyl-piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; Azatadinum [INN-Latin]; Azatadina [INN-Spanish]; 11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[3,4-b]pyridine; Azatadina; Optimine; Azatadinum; Azatidine; Azatadine [INN:BAN]; 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 6,11--dihydro-11-(N-methyl-4-piperidylidene)-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine; Azatadine maleate; Zadine; AZATADINE |
| Molecular Formula | C28H30O8N2 |
| Molecular Weight | 522.55 |
| Purity | 98.00 |
| Density | 1.127 g/cm3 |
| Boiling Point | 450.1ºC at 760 mmHg |
| Melting Point | 124-126ºC |
| Appearance | White or off-white crystalline powder |
| Storage Condition | 2-8℃ |
| Application | Azatadine is an inhibitor of histamine receptors and choline receptors, with IC50s of 6.5 nM and 10 nM respectively. |
| HTC | 2933990090 |
| MDL Number | MFCD00242593 |
| SMILES | CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1 |
| InChI | InChI=1S/C20H22N2/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19/h2-7,12H,8-11,13-14H2,1H3 |
| InChI Key | SEBMTIQKRHYNIT-UHFFFAOYSA-N |
| MSDS | msds/30339_1_3964_81_6.pdf |
| Use of | Properties Name azatadine Synonym More Synonyms Azatadine Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology References [1]. Wilson JD, et al. Azatadine maleate (Zadine): evaluation in the management of allergic rhinitis. N Z Med J. 1981 Aug 12;94(689):79-81. [2]. Tozzi S, et al. The pharmacology of azatadine, a potential antiallergy drug. Agents Actions. 1974 Oct;4(4):264-70. Chemical & Physical Properties Molecular Formula C20H22N2 PSA 16.13000 LogP 3.64560 InChIKey SEBMTIQKRHYNIT-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information HS Code 2933990090 Synthetic Route 5,6-dihydro-11H... CAS#:3964-73-6 CAS#:3964-81-6 Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461 N-tert-butyl-3-... CAS#:32998-95-1 CAS#:3964-81-6 Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461 Benzyl chloride CAS#:100-44-7 CAS#:3964-81-6 Literature: Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461 Precursor & DownStream Precursor 6 CAS#:3964-73-6 5,6-dihydro-11H... CAS#:32998-95-1 N-tert-butyl-3-... CAS#:100-44-7 Benzyl chloride CAS#:14578-23-5 3-phenethyl-pyr... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Heterocyclic Building Blocks | ||
|---|---|---|
| Methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride | 3939-01-3 | 2A-9030310 |
| 5-Cyano-2-fluoropyridine | 3939-12-6 | 2A-9030312 |
| 3-Cyano-2-fluoropyridine | 3939-13-7 | 2A-9030313 |
| Tetrabromothiophene | 3958-03-0 | 2A-9030327 |
| 4-Bromoquinoline | 3964-04-3 | 2A-9030335 |
| 4-Methoxy-4-methylpiperidine hydrochloride | 3970-73-8 | 2A-9030349 |
| 2-Amino-4-hydroxy-6-methylpyrimidine | 3977-29-5 | 2A-9030441 |
| 2-Vinyl-1,3-dioxolane | 3984-22-3 | 2A-9030447 |
| 2-(2-Thienylthio)thiophene | 3988-99-6 | 2A-9030450 |
| 2-Amino-4-chloropyrimidine | 3993-78-0 | 2A-9030454 |
| Browse all Heterocyclic Building Blocks products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS