CAS Number3801-06-7
SynonymsOxylone acetate; FLUOROMETHOLONE ACETATE; (6α,11β)-9-Fluoro-11-hydroxy-6-methyl-3,20-dioxopregna-1,4-dien-17-yl acetate
Molecular FormulaC24H31FO5
Molecular Weight418.51
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point532.1±50.0 °C at 760 mmHg
Melting Point230-232°
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 3801-06-7 |
| Catalog No. | 2A-9030202 |
| Chinese Name | 氟米龙醋酸酯 |
| Synonyms | Oxylone acetate; FLUOROMETHOLONE ACETATE; (6α,11β)-9-Fluoro-11-hydroxy-6-methyl-3,20-dioxopregna-1,4-dien-17-yl acetate |
| Molecular Formula | C24H31FO5 |
| Molecular Weight | 418.51 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 532.1±50.0 °C at 760 mmHg |
| Melting Point | 230-232° |
| Storage Condition | room temperature |
| Application | Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and corticosteroid ester. Fluorometholone acetate potently inhibits carbonic anhydrase (CA) with IC50s of 2.18 μM and 17.5 μM for h |
| HTC | 2942000000 |
| MDL Number | C24H31FO5 |
| SMILES | CC(=O)OC1(C(C)=O)CCC2C3CC(C)C4=CC(=O)C=CC4(C)C3(F)C(O)CC21C |
| InChI | InChI=1S/C24H31FO5/c1-13-10-19-17-7-9-23(14(2)26,30-15(3)27)22(17,5)12-20(29)24(19,25)21(4)8-6-16(28)11-18(13)21/h6,8,11,13,17,19-20,29H,7,9-10,12H2,1-5H3/t13-,17-,19-,20-,21-,22-,23-,24-/m0/s1 |
| InChI Key | YRFXGQHBPBMFHW-SBTZIJSASA-N |
| MSDS | msds/30202_1_3801_06_7.pdf |
| Use of | Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Fluorometholone acetate potently inhibits carbonic anhydrase (CA) with IC50s of 2.18 μM and 17.5 μM for hCA-I and hCA-II, respectively. Fluorometholone acetate has anti-inflammatory effect and has the potential for external ocular inflammation research[1][2][3]. Properties Name fluorometholone acetate Synonym More Synonyms Oxylone acetate Biological Activity Description Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Fluorometholone acetate potently inhibits carbonic anhydrase (CA) with IC50s of 2.18 μM and 17.5 μM for hCA-I and hCA-II, respectively. Fluorometholone acetate has anti-inflammatory effect and has the potential for external ocular inflammation research[1][2][3]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase IC50: 2.18 μM (human carbonic anhydrase (hCA)-I) and 17.5 μM (hCA-II)[2] Ki: 1.044 μM (hCA-I) and 9.98 μM (hCA-II)[2] In Vitro For Fluorometholone acetate, a Ki value from Lineweaver-Burk plots is obtained as 1.044 μM (noncompetitive) for hCA-I and 9.98 μM (non-competitive) for hCA-II[2]. In Vivo Hourly topical administration of 0.1% Fluorometholone acetate ophthalmic suspension produced, on the average, a 47% reduction in the polymorphonuclear leukocytes invading the cornea during an experimentally induced inflammatory keratitis in New Zealand albino rabbits (1.5-2.0 kg). Fluorometholone acetate (0.1%) formulated as a high-viscosity carbomer gel and applied at three-hour intervals reduced invading leukocytes in the cornea an average of 48%, an effect not significantly different from hourly administration of the suspension[1]. References [1]. A Kupferman, et al. Fluorometholone acetate. A new ophthalmic derivative of fluorometholone. Arch Ophthalmol. 1982 Apr;100(4):640-1. [2]. Zuhal Alım, et al. Some Anti-Inflammatory Agents Inhibit Esterase Activities of Human Carbonic Anhydrase Isoforms I and II: An In Vitro Study. Chem Biol Drug Des. 2015 Oct;86(4):857-63. [3]. H M Leibowitz, et al. Fluoro metholone acetate: clinical evaluation in the treatment of external ocular inflammation. Ann Ophthalmol. 1984 Dec;16(12):1110-5. Chemical & Physical Properties Molecular Formula C24H31FO5 Exact Mass 418.215546 PSA 80.67000 Index of Refraction 1.556 InChIKey YRFXGQHBPBMFHW-SBTZIJSASA-N Safety Information RIDADR NONH for all modes of transport HS Code 2942000000 |
| Transport Info | Product Name: Fluorometholone Acetate |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Butanilicaine hydrochloride | 3785-21-5 | 2A-9030190 |
| Sodium (2-carbamoylphenoxy)acetate | 3785-32-8 | 2A-9030191 |
| 1,2-Bis(bromoacetoxy)ethane | 3785-34-0 | 2A-9030192 |
| Sodium L-aspartate | 3792-50-5 | 2A-9030196 |
| (1-Hydroxyethylidene)bis-phosphonic acid tetrasodium salt | 3794-83-0 | 2A-9030197 |
| Scandium acetate | 3804-23-7 | 2A-9030205 |
| Columbianetin | 3804-70-4 | 2A-9030206 |
| 1-Bromo-2-ethylbutane | 3814-34-4 | 2A-9030216 |
| Methyl 2-amino-5-nitrobenzoate | 3816-62-4 | 2A-9030218 |
| 1-Fluoro-3-iodo-5-nitrobenzene | 3819-88-3 | 2A-9030219 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS