CAS Number3687-18-1
Synonymstramiprosate; Homotaurine; 3-aminopropane-1-sulfonic acid; Alzhemed; 3-Aminopropane sulfonic acid; 3-Amino-1-propanesulfonic acid; 3-aminopropane-1-sulphonic acid; 3-Amino-propane-1-sulfonic acid; 3-APS; EINECS 222-977-4; MFCD00008225
Molecular FormulaH2N(CH2)3SO3H
Molecular Weight139.17
Purity97%
Density1.4±0.1 g/cm3
Melting Point293 °C (dec.) (lit.)
Appearancesolid
EINECS222-977-4
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 3687-18-1 |
| Catalog No. | 2A-9030089 |
| Chinese Name | 高牛磺酸 |
| Synonyms | tramiprosate; Homotaurine; 3-aminopropane-1-sulfonic acid; Alzhemed; 3-Aminopropane sulfonic acid; 3-Amino-1-propanesulfonic acid; 3-aminopropane-1-sulphonic acid; 3-Amino-propane-1-sulfonic acid; 3-APS; EINECS 222-977-4; MFCD00008225 |
| Molecular Formula | H2N(CH2)3SO3H |
| Molecular Weight | 139.17 |
| Purity | 97 |
| Density | 1.4±0.1 g/cm3 |
| Melting Point | 293 °C (dec.) (lit.) |
| Appearance | solid |
| Storage Condition | Store airtight in a cool, dry warehouse. |
| Application | Tramiprosate is a small, orally available compound that binds to soluble Aβ, reducing amyloid aggregation and subsequent deposition. |
| EINECS | 222-977-4 |
| HTC | 2921199090 |
| PubChem ID | 24891257 |
| MDL Number | MFCD00008225 |
| SMILES | NCCCS(O)(=O)=O |
| InChI | 1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7) |
| InChI Key | SNKZJIOFVMKAOJ-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| MSDS | msds/30089_1_3687_18_1.pdf |
| Bioactivity | Tramiprosate is a small, orally-administered compound that binds to soluble Aβ and reduces amyloid aggregation and subsequent depositiontarget: AβIn vitro: Tramiprosate provides neuroprotection against Aβ-induced neurotoxicity in neuronal and mouse organotypic hippocampal cultures, and reverses Aβ-induced long-term potentiation (LTP) inhibition in rat hippocampus, in part, through activation of β-aminobutyric acid A (GABA-A) receptors. Tramiprosate dose-dependently provides neuroprotection against ischemic stroke.In vivo: Tramiprosate produced dose-dependent reductions of Aβ in the brain of transgenic mice (hAPP-TgCRND8). Clinical studies show that tramiprosate was safe and tolerable. In mild-to-moderate AD patients tramiprosate also reduced Aβ42 levels in CSF.The reference for animal administration is 50 mg/kg. Related Catalog Signaling Pathways >> Neuronal Signaling >> Amyloid-β Research Areas >> Cancer References [1]. Wu S et al. Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS. Neuropharmacology. 2014 Aug;83:107-17. [2]. Aisen PS et al. Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study). Arch Med Sci. 2011 Feb;7(1):102-11. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Melting Point 293 °C (dec.)(lit.) Molecular Formula C3H9NO3S Molecular Weight 139.173 Exact Mass 139.030319 PSA 88.77000 LogP -2.25 Index of Refraction 1.508 InChIKey SNKZJIOFVMKAOJ-UHFFFAOYSA-N SMILES NCCCS(=O)(=O)O Storage condition Store at 0-5°C |
| Use of | Properties Articles35 Name 3-Amino-1-propanesulfonic acid Synonym More Synonyms Tramiprosate Biological Activity Related Catalog Signaling Pathways >> Neuronal Signaling >> Amyloid-β Research Areas >> Cancer References [1]. Wu S et al. Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS. Neuropharmacology. 2014 Aug;83:107-17. [2]. Aisen PS et al. Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study). Arch Med Sci. 2011 Feb;7(1):102-11. Chemical & Physical Properties Molecular Formula C3H9NO3S Exact Mass 139.030319 PSA 88.77000 LogP -2.25 Index of Refraction 1.508 InChIKey SNKZJIOFVMKAOJ-UHFFFAOYSA-N SMILES NCCCS(=O)(=O)O |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards 3-Amino-1-propanesulfonic acid Modification number: 5 Module 14. Shipping information UN number: not specified |
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