CAS Number3600-87-1
SynonymsST 1059 (Desglymidodrine); 2-amino-1-(2,5-dimethoxyphenyl)ethan-1-ol; (±)-2-amino-1-(2,5-dimethoxyphenyl)ethanol; 1-(2',5'-Dimethoxyphenyl)aminoethanol; 1-(2',5'-dimethoxyphenyl)-2-aminoethanol; de-glymidodrine
Molecular FormulaC10H15NO3
Molecular Weight197.23
Purity98.00%
Boiling Point364.3ºC at 760mmHg
Melting Point146-150ºC dec.
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 3600-87-1 |
| Catalog No. | 2A-9029976 |
| Chinese Name | 2-氨基-1-(2,5-二甲氧基苯基)乙醇 |
| Synonyms | ST 1059 (Desglymidodrine); 2-amino-1-(2,5-dimethoxyphenyl)ethan-1-ol; (±)-2-amino-1-(2,5-dimethoxyphenyl)ethanol; 1-(2',5'-Dimethoxyphenyl)aminoethanol; 1-(2',5'-dimethoxyphenyl)-2-aminoethanol; de-glymidodrine |
| Molecular Formula | C10H15NO3 |
| Molecular Weight | 197.23 |
| Purity | 98.00 |
| Boiling Point | 364.3ºC at 760mmHg |
| Melting Point | 146-150ºC dec. |
| Storage Condition | Keep away from light, in a ventilated and dry plac |
| Application | Diglitamide (ST 1059) is the active metabolite of midodrine and a selective α1-adrenergic receptor agonist. Desglitamide is a potent arterial and venous vasoconstrictor that can be used to regulate bl |
| HTC | 2922509090 |
| PubChem ID | 6801062 |
| SMILES | COc1ccc(OC)c(C(O)CN)c1 |
| InChI | InChI=1S/C10H15NO3.ClH/c1-13-7-3-4-10(14-2)8(5-7)9(12)6-11;/h3-5,9,12H,6,11H2,1-2H3;1H |
| InChI Key | VFRCNXKYZVQYLX-UHFFFAOYSA-N |
| Use of | Desglymidodrine (ST 1059), the active metabolite of midodrine, is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure[1][2]. Properties Name 2-Amino-1-(2,5-dimethoxyphenyl)ethanol Synonym More Synonyms Desglymidodrine Biological Activity Description Desglymidodrine (ST 1059), the active metabolite of midodrine, is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure[1][2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor α1A-adrenergic receptor:5.89 (pKi) α1B-adrenergic receptor:5.16 (pKi) rat alpha1D-adrenergic receptor:5.78 (pKi) human α2A-adrenoceptor:5.83 (pKi) In Vitro Desglymidodrine (ST 1059) (1-1000 μM) affects vein contraction with the pD2 values (negative logarithm of the concentration which causes 50% of the maximum possible effect) of 4.64 (- log mol/L) in dog isolated femoral veins and 4.48 (- log mol/L) in isolated human saphenous veins, respectively[1]. Desglymidodrine (ST 1059) acts on α1A, α1B, α1D in rat and α2A in human adrenoceptor with the pKi values of 5.89, 5.16, 5.78 and 5.83, respectively[2]. References [1]. K Nakayama, et al. Effects of anisotropine methylbromide (Valpin) and its mixture with sulpyrine on vocalization response and spasm of intestine induced by acetylcholine in dogs. Jpn J Pharmacol. 1972 Apr;22(2):215-20. [2]. Steven ABuckner, et al. ABT-866, a novel α1A-adrenoceptor agonist with antagonist properties at the α1B- and α1D-adrenoceptor subtypes,European Journal of Pharmacology,Volume 449, Issues 1-2,2002,Pages 159-1 Chemical & Physical Properties Molecular Formula C10H15NO3 Exact Mass 197.10500 PSA 64.71000 LogP 1.39620 Index of Refraction 1.542 InChIKey VFRCNXKYZVQYLX-UHFFFAOYSA-N Safety Information Hazard Codes Xn RIDADR NONH for all modes of transport HS Code 2922509090 Precursor & DownStream Precursor 4 CAS#:56979-58-9 2-(2,5-dimethox... CAS#:83436-65-1 1,2-epoxy-1-(2,... CAS#:1204-21-3 2-Bromo-1-(2,5-... CAS#:93-02-7 2,5-Dimethoxybe... DownStream 1 CAS#:60681-99-4 2-chloro-N-[2-(... |
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