CAS Number3374-05-8
Synonymsnalidixic acid sodium; sodiumnalidixate; EINECS 222-159-7; MFCD00064376; sodium nalidixicate; sodiumnilixalate; nalidixic acid sodium salt; nalidixic acid,sodium salt; nalidixatesodium; sodium 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate; 8-naphthyridine-3-carboxylicacid,1-ethyl-1,4-dihydro-7-methyl-4-oxo-sodiu
Molecular FormulaC12H11N2NaO3
Molecular Weight254.22
Purity98.00%
Density1.331g/cm3
Boiling Point413.1ºC at 760mmHg
Melting Point229-230ºC
Appearancepowder
EINECS222-159-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 3374-05-8 |
| Catalog No. | 2A-9029720 |
| Chinese Name | 萘啶酸钠盐 |
| Synonyms | nalidixic acid sodium; sodiumnalidixate; EINECS 222-159-7; MFCD00064376; sodium nalidixicate; sodiumnilixalate; nalidixic acid sodium salt; nalidixic acid,sodium salt; nalidixatesodium; sodium 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate; 8-naphthyridine-3-carboxylicacid,1-ethyl-1,4-dihydro-7-methyl-4-oxo-sodiu |
| Molecular Formula | C12H11N2NaO3 |
| Molecular Weight | 254.22 |
| Purity | 98.00 |
| Density | 1.331g/cm3 |
| Boiling Point | 413.1ºC at 760mmHg |
| Melting Point | 229-230ºC |
| Appearance | powder |
| Water Solubility | H2O: 50 mg/mL, clear, faintly yellow |
| Storage Condition | 2-8℃, avoid light, ventilated and dry place, seale |
| Application | Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both Gram-positive and Gram-negative bacteria. Nalidixic acid sodium salt acts in a bacteriostatic manner at lower concentratio |
| EINECS | 222-159-7 |
| HTC | 2933990090 |
| PubChem ID | 24278589 |
| MDL Number | MFCD00064376 |
| SMILES | [Na+].CCN1C=C(C([O-])=O)C(=O)c2ccc(C)nc12 |
| InChI | 1S/C12H12N2O3.Na/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14;/h4-6H,3H2,1-2H3,(H,16,17);/q;+1/p-1 |
| InChI Key | ROKRAUFZFDQWLE-UHFFFAOYSA-M |
| Beilstein/REAXYS | 3580062 |
| NACRES Code | NA.77 |
| UNSPSC | 12352106 |
| Hazard Symbols | transportation |
| MSDS | msds/29720_1_3374_05_8.pdf |
| Bioactivity | Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1][2]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial Target Topoisomerase In Vitro Nalidixic acid is against a variety of microorganisms, it is against with Escherichia coli, Pasteurella spp., Klebsiella pneuiiioniae, Aerobacter aeroyenes, Proteus spp., Salmonella spp., Shigella spp. and Brucella spp. with MIC values of 5.0-12.5 μg/ml, 0.5-2.5 μg/ml, 0.8-25.0 μg/ml, 1.0-25.0 μg/ml, 1.25-30.0 μg/ml, 8-3.2 μg/ml, and 7.5-10.0 μg/ml, respectively[1]. In Vivo The in vivo activity of Nalidixic acid is most pronounced against Gram-negative bacteria, while Gram-positive organisms are generally more resistant. Maximal activity is observed against systemic infections caused by E. coli, A. aerobacter, Proteus mirabilis, Shigella fkxneri, the ED50 values are 25 mg/kg, 60 mg/kg, 50 mg/kg, and 62 mg/kg, respectively[1]. The acute toxicity (LD50) of Nalidixic acid in mice following oral and parenteral administration is: oral, 3300 mg/kg; intravenous, 176 mg/kg; and subcutaneous, 500 mg/kg[1]. References [1]. G Y LESHER,et al. 1,8-NAPHTHYRIDINE DERIVATIVES. A NEW CLASS OF CHEMOTHERAPEUTIC AGENTS. J Med Pharm Chem. 1962 Sep;91:1063-5. [2]. Anna Fàbrega, et al. Mechanism of Action of and Resistance to Quinolones. Microb Biotechnol Chemical & Physical Properties Density 1.331g/cm3 Boiling Point 413.1ºC at 760mmHg Melting Point 229-230ºC Molecular Formula C12H11N2NaO3 Molecular Weight 254.21700 Flash Point 203.6ºC Exact Mass 254.06700 PSA 75.02000 LogP 0.08830 InChIKey ROKRAUFZFDQWLE-UHFFFAOYSA-M SMILES CCn1cc(C(=O)[O-])c(=O)c2ccc(C)nc21.[Na+] Storage condition 2-8°C Water Solubility H2O: 50 mg/mL, clear, faintly yellow |
| Use of | Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1][2]. Properties Articles32 Name Nalidixic acid sodium salt Synonym More Synonyms Nalidixic acid sodium salt Biological Activity Description Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1][2]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial Topoisomerase In Vitro Nalidixic acid is against a variety of microorganisms, it is against with Escherichia coli, Pasteurella spp., Klebsiella pneuiiioniae, Aerobacter aeroyenes, Proteus spp., Salmonella spp., Shigella spp. and Brucella spp. with MIC values of 5.0-12.5 μg/ml, 0.5-2.5 μg/ml, 0.8-25.0 μg/ml, 1.0-25.0 μg/ml, 1.25-30.0 μg/ml, 8-3.2 μg/ml, and 7.5-10.0 μg/ml, respectively[1]. References [1]. G Y LESHER,et al. 1,8-NAPHTHYRIDINE DERIVATIVES. A NEW CLASS OF CHEMOTHERAPEUTIC AGENTS. J Med Pharm Chem. 1962 Sep;91:1063-5. [2]. Anna Fàbrega, et al. Mechanism of Action of and Resistance to Quinolones. Microb Biotechnol Chemical & Physical Properties Molecular Formula C12H11N2NaO3 Exact Mass 254.06700 PSA 75.02000 LogP 0.08830 InChIKey ROKRAUFZFDQWLE-UHFFFAOYSA-M |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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