CAS Number2997-92-4
Synonyms2,2-AZOBIS-(2-AMIDINOPROPANE) HCL; AAPH; Azostarter V 50; ms1; ABAP; 2,2-Azobis(2-Methylpropionamidine) Dihydrochloride; ms1(catalyst); v50; 2,2'-Azobis(2; 2,2′-azobis(isobutyramidine) dihydrochloride; Propanimidamide, 2,2'-[(E)-1,2-diazenediyl]bis[2-methyl-, hydrochloride (1:2); 2,2'-Azobis(2-methylpropionamidine) dihydrochloride; 2,2'-azobis(2-methyl-2-propionamidine) dihydrochloride; 2,2'-azobisi(2-amidinopropane) hydrochloride; 2,2'-Azobis(2-methylpropionamidine) Dihydrochloride; 2,2'-(Diazene-1,2-diyl)bis(2-methylpropanimidamide) dihydrochloride; 2,2'-(e)-diazene-1,2-diylbis(2-methylpropanimidamide) dihydrochloride; EINECS 221-070-0; 2,2'-Azodiisobutyramidine Dihydrochloride; MFCD00142725; 2,2'-[(E)-1,2-Diazenediyl]bis(2-methylpropanimidamide) dihydrochloride; 2,2'-Azobis-amidinopropa
Molecular Formula[=NC(CH3)2C(=NH)NH2]2·2HCl
Molecular Weight271.19
Purity97%
Density0.42
Boiling Point267ºC at 760 mmHg
Melting Point175-177 °C (lit.)
Appearancepowder or granules
EINECS221-070-0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2997-92-4 |
| Catalog No. | 2A-9029286 |
| Chinese Name | 2,2'-偶氮双(2-甲基丙脒)二盐酸盐 |
| Synonyms | 2,2-AZOBIS-(2-AMIDINOPROPANE) HCL; AAPH; Azostarter V 50; ms1; ABAP; 2,2-Azobis(2-Methylpropionamidine) Dihydrochloride; ms1(catalyst); v50; 2,2'-Azobis(2; 2,2′-azobis(isobutyramidine) dihydrochloride; Propanimidamide, 2,2'-[(E)-1,2-diazenediyl]bis[2-methyl-, hydrochloride (1:2); 2,2'-Azobis(2-methylpropionamidine) dihydrochloride; 2,2'-azobis(2-methyl-2-propionamidine) dihydrochloride; 2,2'-azobisi(2-amidinopropane) hydrochloride; 2,2'-Azobis(2-methylpropionamidine) Dihydrochloride; 2,2'-(Diazene-1,2-diyl)bis(2-methylpropanimidamide) dihydrochloride; 2,2'-(e)-diazene-1,2-diylbis(2-methylpropanimidamide) dihydrochloride; EINECS 221-070-0; 2,2'-Azodiisobutyramidine Dihydrochloride; MFCD00142725; 2,2'-[(E)-1,2-Diazenediyl]bis(2-methylpropanimidamide) dihydrochloride; 2,2'-Azobis-amidinopropa |
| Molecular Formula | [=NC(CH3)2C(=NH)NH2]2·2HCl |
| Molecular Weight | 271.19 |
| Purity | 97 |
| Density | 0.42 |
| Boiling Point | 267ºC at 760 mmHg |
| Melting Point | 175-177 °C (lit.) |
| Appearance | powder or granules |
| Water Solubility | acetone, dioxane, methanol, ethanol, DMSO and wate |
| Storage Condition | Sealed in a cool, dry environment at 0-6 ºC |
| Packaging | III |
| Application | AAPH (2,2'-Azodiisobutyramidine dihydrochloride) has free radical generating properties. AAPH induces oxidative stress and erythrocyte hemolysis. |
| EINECS | 221-070-0 |
| PubChem ID | 24867630 |
| MDL Number | MFCD00142725 |
| SMILES | Cl.Cl.CC(C)(\N=N\C(C)(C)C(N)=N)C(N)=N |
| InChI | 1S/C8H18N6.2ClH/c1-7(2,5(9)10)13-14-8(3,4)6(11)12;;/h1-4H3,(H3,9,10)(H3,11,12);2*1H/b14-13+;; |
| InChI Key | LXEKPEMOWBOYRF-QDBORUFSSA-N |
| Beilstein/REAXYS | 3718854 |
| NACRES Code | NA.23 |
| UNSPSC | 12162002 |
| Hazard Symbols | 5.1 |
| MSDS | msds/29286_1_2997_92_4.pdf |
| Bioactivity | AAPH (2,2'-Azodiisobutyramidine dihydrochloride) has an effect of radical generation. AAPH induces oxidative stress and erythrocyte hemolysis[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology References [1]. Sean M. Culbertson, et al. Unsymmetrical Azo Initiators Increase Efficiency of Radical Generation in Aqueous Dispersions, Liposomal Membranes, and Lipoproteins. J. Am. Chem. Soc. 2000, 122, 17, 4032-4038. [2]. Liao W, et al. Intracellular antioxidant detoxifying effects of diosmetin on 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress through inhibition of reactive oxygen species generation. J Agric Food Chem. 2014 Aug 27;62(34):8648-54. Chemical & Physical Properties Density 0.42 Boiling Point 267ºC at 760 mmHg Melting Point 160-169 ºC Molecular Formula C8H20Cl2N6 Molecular Weight 271.191 Flash Point 115.3ºC Exact Mass 270.112640 PSA 124.46000 LogP 4.07180 Vapour Pressure 8.02E-05mmHg at 25°C InChIKey LXEKPEMOWBOYRF-UHFFFAOYSA-N SMILES CC(C)(N=NC(C)(C)C(=N)N)C(=N)N.Cl.Cl Stability Unstable. Sensitive to heat and light. Incompatible with strong oxidizing agents, strong acids. Water Solubility acetone, dioxane, methanol, ethanol, DMSO and water: soluble |
| Use of | AAPH (2,2'-Azodiisobutyramidine dihydrochloride) has an effect of radical generation. AAPH induces oxidative stress and erythrocyte hemolysis[1]. Properties Articles47 Name 2,2'-Azobis(2-methylpropionamidine) dihydrochloride Synonym More Synonyms Biological Activity Description AAPH (2,2'-Azodiisobutyramidine dihydrochloride) has an effect of radical generation. AAPH induces oxidative stress and erythrocyte hemolysis[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology References [1]. Sean M. Culbertson, et al. Unsymmetrical Azo Initiators Increase Efficiency of Radical Generation in Aqueous Dispersions, Liposomal Membranes, and Lipoproteins. J. Am. Chem. Soc. 2000, 122, 17, 4032-4038. [2]. Liao W, et al. Intracellular antioxidant detoxifying effects of diosmetin on 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress through inhibition of reactive oxygen species generation. J Agric Food Chem. 2014 Aug 27;62(34):8648-54. Chemical & Physical Properties Exact Mass 270.112640 PSA 124.46000 LogP 4.07180 InChIKey LXEKPEMOWBOYRF-UHFFFAOYSA-N SMILES CC(C)(N=NC(C)(C)C(=N)N)C(=N)N.Cl.Cl Stability Unstable. Sensitive to heat and light. Incompatible with strong oxidizing agents, strong acids. Water Solubility acetone, dioxane, methanol, ethanol, DMSO and water: soluble |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3226 International Maritime Danger Regulations: 3226 International Air Transport Danger Regulations: 3226 14.2 United Nations shipping name European Land Transport Dangerous Regulations: SELF-REACTIVE SOLID TYPE D (2,2'-AZOBIS(2-AMIDINOPROPANE)- DIHYDROCHLORIDE) (2,2'-Azobis[2-methylpropionamidine] dihydrochloride) IMDG: SELF-REACTIVE SOLID TYPE D (2,2'-AZOBIS(2-AMIDINOPROPANE)- DIHYDROCHLORIDE) (2,2'-Azobis[2-methylpropionamidine] dihydrochloride) International air transport hazard regulations: Self-reactive solid type D (2,2'-AZOBIS(2-AMIDINOPROPANE)-DIHYDROCHLORIDE) (2,2'-Azobis[2-methylpropionamidine] dihydrochloride) Special measures: "Keep away from heat" label required. 14.3 Transport hazard categories European Land Transport Dangerous Regulations: 4.1 International Maritime Transport Dangerous Regulations: 4.1 International Air Transport Dangerous Regulations: 4.1 (HEAT) 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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