CAS Number2799-07-7
SynonymsS-Triphenylmethyl-L-cysteine; Cys(Trt)-OH; 3-tritylthio-L-alanine; L-Cys(trt)-OH; EINECS 218-195-8; S-Tritylcysteine; (R)-S-Tritylcysteine; (2S)-2-Ammonio-3-(tritylsulfanyl)propanoate; S-Trt-L-Lys-OH; H-Cys(Trt)-OH; TRITYL-L-CYSTEINE; H-L-Cys(Trt)-OH; MFCD00002611; CYSTEINE(TRT)-OH; Tritylthioalanine
Molecular Formula(C6H5)3CSCH2CH(NH2)CO2H
Molecular Weight363.47
Purity97%
Density1.2±0.1 g/cm3
Boiling Point524.7±50.0 °C at 760 mmHg
Melting Point182-183 °C (dec.) (lit.)
AppearanceAlmost white to light yellow granular powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2799-07-7 |
| Catalog No. | 2A-9029024 |
| Chinese Name | S-三苯甲基-L-半胱氨酸 |
| Synonyms | S-Triphenylmethyl-L-cysteine; Cys(Trt)-OH; 3-tritylthio-L-alanine; L-Cys(trt)-OH; EINECS 218-195-8; S-Tritylcysteine; (R)-S-Tritylcysteine; (2S)-2-Ammonio-3-(tritylsulfanyl)propanoate; S-Trt-L-Lys-OH; H-Cys(Trt)-OH; TRITYL-L-CYSTEINE; H-L-Cys(Trt)-OH; MFCD00002611; CYSTEINE(TRT)-OH; Tritylthioalanine |
| Molecular Formula | (C6H5)3CSCH2CH(NH2)CO2H |
| Molecular Weight | 363.47 |
| Purity | 97 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 524.7±50.0 °C at 760 mmHg |
| Melting Point | 182-183 °C (dec.) (lit.) |
| Appearance | Almost white to light yellow granular powder |
| Storage Condition | Sealed in a cool, dry environment at -20 ºC |
| Application | S-triphenyl-L-cysteine (NSC 83265) is a selective allosteric kinesin Eg5 inhibitor with an IC50 of 1 μM for inhibiting basal ATPase activity and 140 nM for inhibiting microtubule-activated ATPase ac |
| HTC | 2930909090 |
| PubChem ID | 24850097 |
| MDL Number | MFCD00002611 |
| SMILES | N[C@@H](CSC(c1ccccc1)(c2ccccc2)c3ccccc3)C(O)=O |
| InChI | 1S/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)/t20-/m0/s1 |
| InChI Key | DLMYFMLKORXJPO-FQEVSTJZSA-N |
| Beilstein/REAXYS | 2339626 |
| NACRES Code | NA.22 |
| eCl@ss | 32160406 |
| UNSPSC | 12352209 |
| Hazard Symbols | transportation |
| MSDS | msds/29024_1_2799_07_7.pdf |
| Bioactivity | S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC50 of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Kinesin Signaling Pathways >> Cytoskeleton >> Kinesin Target Eg5 In Vitro S-Trityl-L-cysteine binds to a unique pocket in the Eg5 motor domain formed by secondary structural elements (helix a2/loop L5/helix a3)[1]. S-Trityl-L-cysteine (1-20 µM; for 72 h) could mediate cell apoptosis, as well as cell cycle arrest, in a dose-dependent manner. S-Trityl-L-cysteine-mediated apoptosis and cell cycle arrest were triggered by activation of the mitogen-activated protein kinase and nuclear factor kB signaling pathways[1]. S-Trityl-L-cysteine induces mitotic arrest in HeLa cells (IC50 of 700 nM) with characteristic monoastral spindles[2]. References [1]. Wei Wu, et al. S-trityl-L-cysteine, a novel Eg5 inhibitor, is a potent chemotherapeutic strategy in neuroblastoma. Oncol Lett. 2018 Jul;16(1):1023-1030. [2]. Salvatore DeBonis, et al. In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities. Mol Cancer Ther. 2004 Sep;3(9):1079-90. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 524.7±50.0 °C at 760 mmHg Melting Point 182-183 °C (dec.)(lit.) Molecular Formula C22H21NO2S Molecular Weight 363.47 Flash Point 271.2±30.1 °C Exact Mass 363.129303 PSA 88.62000 LogP 5.56 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.642 InChIKey DLMYFMLKORXJPO-FQEVSTJZSA-N SMILES NC(CSC(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)O Storage condition -20°C |
| Use of | S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC50 of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities[1][2]. Properties Articles30 Name S-Trityl-L-cysteine Synonym More Synonyms S-Tritylcysteine Biological Activity Description S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC50 of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Kinesin Signaling Pathways >> Cytoskeleton >> Kinesin References [1]. Wei Wu, et al. S-trityl-L-cysteine, a novel Eg5 inhibitor, is a potent chemotherapeutic strategy in neuroblastoma. Oncol Lett. 2018 Jul;16(1):1023-1030. [2]. Salvatore DeBonis, et al. In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities. Mol Cancer Ther. 2004 Sep;3(9):1079-90. Chemical & Physical Properties Molecular Formula C22H21NO2S Exact Mass 363.129303 PSA 88.62000 Index of Refraction 1.642 InChIKey DLMYFMLKORXJPO-FQEVSTJZSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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