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Home > Products > Food & Nutrition > Specialty & Botanical Ingredients > 7-Acetoxy-4-methylcoumarin
7-Acetoxy-4-methylcoumarin structure, CAS 2747-05-9

7-Acetoxy-4-methylcoumarin

CAS Number2747-05-9

Synonyms4-Methylumbeliferyl acetate; 4-Methylumbelliferyl Acetate; 7-Aceoxy-4-MethylcouMarin; EINECS 220-386-6; MUB ACETATE; acetic acid 4-methyl-2-oxo-2H-chromen-7-yl ester; 7-Acetoxy-4-methylcoumarin; 7-ACETYL-4-METHYLCOUMARIN; MUACETATE; 4-METHYL-7-ACETOXYCOUMARIN; 4-methyl-2-oxo-2H-chromen-7-yl acetate; METHYLUMBELLIFERYL ACETATE; 7-acetoxy-4-methyl-chromen-2-one; MFCD00006865

Molecular FormulaC12H10O4

Molecular Weight218.21

Purity≥98 (TLC)%

Density1.263g/cm3

Boiling Point371.4ºC at 760mmHg

Melting Point149-150 °C (lit.)

Flash Point

Appearancepowder

EINECS220-386-6

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-9028967 Purity: ≥98 (TLC)%
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Quality Control of [ 2747-05-9 ] Purity: ≥98 (TLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number2747-05-9
Catalog No.2A-9028967
Chinese Name7-乙酰氧基-4-甲基香豆素
Synonyms4-Methylumbeliferyl acetate; 4-Methylumbelliferyl Acetate; 7-Aceoxy-4-MethylcouMarin; EINECS 220-386-6; MUB ACETATE; acetic acid 4-methyl-2-oxo-2H-chromen-7-yl ester; 7-Acetoxy-4-methylcoumarin; 7-ACETYL-4-METHYLCOUMARIN; MUACETATE; 4-METHYL-7-ACETOXYCOUMARIN; 4-methyl-2-oxo-2H-chromen-7-yl acetate; METHYLUMBELLIFERYL ACETATE; 7-acetoxy-4-methyl-chromen-2-one; MFCD00006865
Molecular FormulaC12H10O4
Molecular Weight218.21
Purity≥98 (TLC)
Density1.263g/cm3
Boiling Point371.4ºC at 760mmHg
Melting Point149-150 °C (lit.)
Appearancepowder
Storage ConditionSealed in a cool, dry environment at -20 ºC
Application7-Acetoxy-4-methylcoumarin is an inhibitor of GST. 7-Acetoxy-4-methylcoumarin inhibits AFB1-DNA binding in vitro, with an inhibition rate of 36.7%.
EINECS220-386-6
HTC2932209090
PubChem ID24896576
MDL NumberMFCD00006865
SMILESCC(=O)Oc1ccc2C(C)=CC(=O)Oc2c1
InChI1S/C12H10O4/c1-7-5-12(14)16-11-6-9(15-8(2)13)3-4-10(7)11/h3-6H,1-2H3
InChI KeyHXVZGASCDAGAPS-UHFFFAOYSA-N
Beilstein/REAXYS189667
NACRES CodeNA.32
UNSPSC12352204
Hazard Symbolstransportation
Risk CodesR36/37/38
Safety DescriptionS26;S36
MSDSmsds/28967_1_2747_05_9.pdf
Bioactivity7-Acetoxy-4-methylcoumarin is an inhibitor of GST.7-Acetoxy-4-methylcoumarin inhibits AFB1-DNA binding in vitro with 36.7% inhibition[1][2]. Related Catalog Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> Gutathione S-transferase References [1]. Feuer, G, et al. Induction of drug-metabolizing enzymes of rat liver by derivatives of coumarin. Canadian Journal of Physiology and Pharmacology, 48(4), 232-240. [2]. Raj HG, et al. Mechanism of biochemical action of substituted benzopyran-2-ones. Part 8: Acetoxycoumarin: protein transacetylase specificity for aromatic nuclear acetoxy groups in proximity to the oxygen heteroatom. Bioorg Med Chem. 2001 May;9(5):1085-9. Chemical & Physical Properties Density 1.263g/cm3 Boiling Point 371.4ºC at 760mmHg Melting Point 149-150 °C(lit.) Molecular Formula C12H10O4 Molecular Weight 218.20500 Flash Point 191.5ºC Exact Mass 218.05800 PSA 56.51000 LogP 2.02670 Vapour Pressure 8.68E-06mmHg at 25°C Index of Refraction 1.588 InChIKey HXVZGASCDAGAPS-UHFFFAOYSA-N SMILES CC(=O)Oc1ccc2c(C)cc(=O)oc2c1 Storage condition −20°C
Use of7-Acetoxy-4-methylcoumarin is an inhibitor of GST.7-Acetoxy-4-methylcoumarin inhibits AFB1-DNA binding in vitro with 36.7% inhibition[1][2]. Properties Articles21 Name 4-methylumbelliferyl acetate Synonym More Synonyms 7-Acetoxy-4-methylcoumarin Biological Activity Description 7-Acetoxy-4-methylcoumarin is an inhibitor of GST.7-Acetoxy-4-methylcoumarin inhibits AFB1-DNA binding in vitro with 36.7% inhibition[1][2]. Related Catalog Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> Gutathione S-transferase References [1]. Feuer, G, et al. Induction of drug-metabolizing enzymes of rat liver by derivatives of coumarin. Canadian Journal of Physiology and Pharmacology, 48(4), 232-240. [2]. Raj HG, et al. Mechanism of biochemical action of substituted benzopyran-2-ones. Part 8: Acetoxycoumarin: protein transacetylase specificity for aromatic nuclear acetoxy groups in proximity to the oxygen heteroatom. Bioorg Med Chem. 2001 May;9(5):1085-9. Chemical & Physical Properties Molecular Formula C12H10O4 Exact Mass 218.05800 PSA 56.51000 LogP 2.02670 Index of Refraction 1.588 InChIKey HXVZGASCDAGAPS-UHFFFAOYSA-N
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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