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Acadesine structure, CAS 2627-69-2

Acadesine

CAS Number2627-69-2

SynonymsAIC-Riboside; EINECS 220-097-5; 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside; AICA Riboside; T5OTJ B1Q CQ DQ E- AT5N CNJ DVQ EZ &&Ribo-β-D Form; 5-Amino-1-b-D-ribofuranosyl-1H-imidazole-4-carboxamide; Z-RIBOSIDE; 5-Amino-4-imidazolecarboxamide ribonucleoside; 5-Amino-1-(β-D-ribofuranosyl)-1H-imidazole-4-carboxamide; 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside; AICA-riboside; GP 1-110; MFCD00869751; Acadesine; Arasine; AMPK; AICAR; 5-Amino-1-β-ribofuranosyl-imidazole-4-carboxamide; 5-Amino-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide; 5-amino-4-imidazole carboxamide ribonucleoside

Molecular FormulaC9H14N4O5

Molecular Weight258.23

Purity98.00%

Density2.1±0.1 g/cm3

Boiling Point726.3±60.0 °C at 760 mmHg

Melting Point214-215 °C

Flash Point

Appearancesolid

EINECS220-097-5

MSDSChineseEnglish

SymbolXi

Signal WordWarning

Cat. No.: 2A-9028833 Purity: 98.00%
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Quality Control of [ 2627-69-2 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number2627-69-2
Catalog No.2A-9028833
Chinese Name阿卡地辛
SynonymsAIC-Riboside; EINECS 220-097-5; 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside; AICA Riboside; T5OTJ B1Q CQ DQ E- AT5N CNJ DVQ EZ &&Ribo-β-D Form; 5-Amino-1-b-D-ribofuranosyl-1H-imidazole-4-carboxamide; Z-RIBOSIDE; 5-Amino-4-imidazolecarboxamide ribonucleoside; 5-Amino-1-(β-D-ribofuranosyl)-1H-imidazole-4-carboxamide; 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside; AICA-riboside; GP 1-110; MFCD00869751; Acadesine; Arasine; AMPK; AICAR; 5-Amino-1-β-ribofuranosyl-imidazole-4-carboxamide; 5-Amino-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide; 5-amino-4-imidazole carboxamide ribonucleoside
Molecular FormulaC9H14N4O5
Molecular Weight258.23
Purity98.00
Density2.1±0.1 g/cm3
Boiling Point726.3±60.0 °C at 760 mmHg
Melting Point214-215 °C
Appearancesolid
Water SolubilityH2O: >10 mg/mL
Storage ConditionSealed in a cool, dry environment at -20ºC.
ApplicationAICAR is a cell-permeable AMP-activated protein kinase (AMPK) activator.
EINECS220-097-5
HTC2934999090
PubChem ID7247
SMILESNC(=O)c1ncn(C2OC(CO)C(O)C2O)c1N
InChIInChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
InChI KeyRTRQQBHATOEIAF-UUOKFMHZSA-N
Hazard SymbolsXi
Risk CodesR36/37/38
Safety DescriptionS26;S36
Use ofAICAR is a cell-permeable AMP-activated protein kinase (AMPK) activator. Properties Articles121 Name aicar Synonym More Synonyms Acadesine (AICAR) Biological Activity Description AICAR is a cell-permeable AMP-activated protein kinase (AMPK) activator. Related Catalog Signaling Pathways >> Epigenetics >> AMPK Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Cancer References [2]. Drake JC, et al. AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1546-54. [3]. Pold R, et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats.Diabetes. 2005 Apr;54(4):928-34. [4]. Chen L, et al. Activating AMPK to Restore Tight Junction Assembly in Intestinal Epithelium and to Attenuate Experimental Colitis by Metformin. Front Pharmacol. 2018 Jul 16;9:761. Chemical & Physical Properties Molecular Formula C9H14N4O5 Exact Mass 258.096405 PSA 156.85000 LogP -2.93 Index of Refraction 1.821 InChIKey RTRQQBHATOEIAF-UUOKFMHZSA-N SMILES NC(=O)c1ncn(C2OC(CO)C(O)C2O)c1N Safety Information Signal Word Warning Hazard Statements H315-H319-H335 Precautionary Statements P261-P305 + P351 + P338 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xi: Irritant; Safety Phrases S26-S36 RIDADR NONH for all modes of transport WGK Germany 3 HS Code 2934999090 Synthetic Route 9-((2R,3R,4S,5R... 659746-61-9 Acadesine (AICA... Literature: Kohyama, Naoki; Yamamoto, Yukio Synthesis, 2003 , # 17 p. 2639 - 2642 5-azido-1-&beta... 129878-03-1 Acadesine (AICA... Literature: Saito; Asahi; Nakajima; Fujii Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 11 p. 2263 - 2268 197437-76-6 Acadesine (AICA... Literature: Firestine, Steven M.; Wu, Weidong; Youn, Hasik; Jo Davisson Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 2 p. 794 - 803 Precursor & DownStream Precursor 6 CAS#:659746-61-9 9-((2R,3R,4S,5R... CAS#:23192-64-5 1H-Imidazole-4-... CAS#:58-63-9 CAS#:3181-38-2 2',3',5'-Tri-O-... DownStream 9 CAS#:3676-72-0 N2-Benzoylguanosine CAS#:50924-49-7 Mizoribine CAS#:59354-00-6 5-Iodo-1-(2',3'... CAS#:360-97-4 5-Amino-4-imida...
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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