CAS Number2451-62-9
SynonymsXB 2615; tgt; (RS,RS,SR)-1,3,5-Tris(2,3-epoxypropyl)-s-triazine-2,4,6(1H,3H,5H)-trione; Teroxirone; EINECS 219-514-3; TGIC; 1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione,TGIC,Triglycidyl isocyanurate; 1,3,5-Tris(2-oxiranylmethyl)-1,3,5-triazinane-2,4,6-trione; Isocyanuric Acid Triglycidyl Ester; T6NVNVNVJ A1- BT3OTJ& C1- BT3OTJ& E1- BT3OTJ; 1,3,5-triglycidyl-s-triazinetrione; MFCD00080670; araldite pt-810; triglycidyl; Triglycidyl Isocyanurate; TEPIC; Tris(2,3-epoxypropyl) Isocyanurate; TGIC,triglycidyl isocyanurate; 1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione; glycidylisocyanurate; Isocyanuric Acid Tris(2,3-epoxypropyl) Ester
Molecular FormulaC12H15N3O6
Molecular Weight297.26
Purity98.00%
Density1.6±0.1 g/cm3
Boiling Point501.1±15.0 °C at 760 mmHg
Melting Point95-98°C
Appearancepowder
EINECS219-514-3
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2451-62-9 |
| Catalog No. | 2A-9028562 |
| Chinese Name | 异氰尿酸三缩水甘油酯 |
| Synonyms | XB 2615; tgt; (RS,RS,SR)-1,3,5-Tris(2,3-epoxypropyl)-s-triazine-2,4,6(1H,3H,5H)-trione; Teroxirone; EINECS 219-514-3; TGIC; 1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione,TGIC,Triglycidyl isocyanurate; 1,3,5-Tris(2-oxiranylmethyl)-1,3,5-triazinane-2,4,6-trione; Isocyanuric Acid Triglycidyl Ester; T6NVNVNVJ A1- BT3OTJ& C1- BT3OTJ& E1- BT3OTJ; 1,3,5-triglycidyl-s-triazinetrione; MFCD00080670; araldite pt-810; triglycidyl; Triglycidyl Isocyanurate; TEPIC; Tris(2,3-epoxypropyl) Isocyanurate; TGIC,triglycidyl isocyanurate; 1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione; glycidylisocyanurate; Isocyanuric Acid Tris(2,3-epoxypropyl) Ester |
| Molecular Formula | C12H15N3O6 |
| Molecular Weight | 297.26 |
| Purity | 98.00 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 501.1±15.0 °C at 760 mmHg |
| Melting Point | 95-98°C |
| Appearance | powder |
| Water Solubility | <0.1 g/100 mL at 20 ºC |
| Storage Condition | Store in a cool, dry warehouse. |
| Packaging | III |
| Application | Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide compound with anti-angiogenic and anti-tumor activity. Triglycidyl isocyanurate inhibits the growth of non-small cell lung cancer c |
| EINECS | 219-514-3 |
| HTC | 2933699090 |
| PubChem ID | 24863665 |
| MDL Number | MFCD00080670 |
| SMILES | O=C1N(CC2CO2)C(=O)N(CC3CO3)C(=O)N1CC4CO4 |
| InChI | 1S/C12H15N3O6/c16-10-13(1-7-4-19-7)11(17)15(3-9-6-21-9)12(18)14(10)2-8-5-20-8/h7-9H,1-6H2 |
| InChI Key | OUPZKGBUJRBPGC-UHFFFAOYSA-N |
| NACRES Code | NA.23 |
| UNSPSC | 12162002 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/28562_1_2451_62_9.pdf |
| Bioactivity | Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53 Research Areas >> Inflammation/Immunology In Vitro Triglycidyl isocyanurate (0-30 μM; 48 hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells[1]. Triglycidyl isocyanurate (0-30 μM; 48 hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472 of A549, H460 and H1299 tumorspheres, however, the cleavage of PARP and procaspase-3 plus the emergent active caspase-3 fragment are only visible in H460 and A549 tumorspheres[1]. Cell Viability Assay[1] Cell Line: A549, H460 and H1299 cells Concentration: 0 μM; 5 μM; 10 μM; 30 μM Incubation Time: 48 hours Result: Inhibited tumor cells growth in soft agar. Western Blot Analysis[1] Cell Line: A549, H460 and H1299 cells Concentration: 0 μM; 5 μM; 10 μM; 30 μM Incubation Time: 48 hours Result: Inhibited akt1/2/3 expression and p-aktser473/474/472 expression of A549, H460 and H1299 tumorspheres In Vivo Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2-3 days for total seven times; 30 days) suppresses the growth of xenograft tumors and has no effects on weight in nude mice[2]. Animal Model: Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area[2] Dosage: 1.8 mg/kg and 3.6 mg/kg Administration: Subcutaneous injection; every 2-3 days for total seven times; 30 days Result: Inhibited the growth of xenograft tumors. References [1]. Yu-Ling Ni, et al. Teroxirone motivates apoptotic death in tumorspheres of human lung cancer cells. Chem Biol Interact. 2018 Aug 1;291:137-143 [2]. Seung-Hun Kim, et al. Teroxirone suppresses growth and motility of human hepatocellular carcinoma cells.Biomed Pharmacother. 2018 Mar;99:997-1008 Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 501.1±15.0 °C at 760 mmHg Melting Point 95-98°C Molecular Formula C12H15N3O6 Molecular Weight 297.264 Flash Point 256.9±20.4 °C Exact Mass 297.096100 PSA 103.59000 LogP -2.77 Vapour Pressure 0.0±1.3 mmHg at 25°C Index of Refraction 1.635 InChIKey OUPZKGBUJRBPGC-UHFFFAOYSA-N SMILES O=c1n(CC2CO2)c(=O)n(CC2CO2)c(=O)n1CC1CO1 Water Solubility <0.1 g/100 mL at 20 ºC |
| Use of | Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research[1][2]. Properties Articles27 Name 1,3,5-Triglycidyl isocyanurate Synonym More Synonyms Triglycidyl isocyanurate Biological Activity Description Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research[1][2]. Related Catalog Research Areas >> Cancer Research Areas >> Inflammation/Immunology References [1]. Yu-Ling Ni, et al. Teroxirone motivates apoptotic death in tumorspheres of human lung cancer cells. Chem Biol Interact. 2018 Aug 1;291:137-143 [2]. Seung-Hun Kim, et al. Teroxirone suppresses growth and motility of human hepatocellular carcinoma cells.Biomed Pharmacother. 2018 Mar;99:997-1008 Chemical & Physical Properties Molecular Formula C12H15N3O6 Exact Mass 297.096100 PSA 103.59000 LogP -2.77 Index of Refraction 1.635 InChIKey OUPZKGBUJRBPGC-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 United Nations number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (TGIC) International Maritime Risk Code: TOXIC SOLID, ORGANIC, N.O.S. (TGIC) International Air Transport Risk Regulation: Toxic solid, organic, n.o.s. (TGIC) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special precautions No data available |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| 9-Vinylanthracene | 2444-68-0 | 2A-9028546 |
| 2-Methylbutyl isobutyrate | 2445-69-4 | 2A-9028548 |
| Hexyl propionate | 2445-76-3 | 2A-9028549 |
| 2-Methylbutyl isovalerate | 2445-77-4 | 2A-9028550 |
| 2-Propynylamine | 2450-71-7 | 2A-9028561 |
| 1,3-Dioxan-2-one | 2453-03-4 | 2A-9028563 |
| 2-Aminothiobenzamide | 2454-39-9 | 2A-9028565 |
| 3,3',5,5'-Tetra-tert-butyldiphenoquinone | 2455-14-3 | 2A-9028566 |
| Tetrahydrofurfuryl methacrylate | 2455-24-5 | 2A-9028567 |
| Methyl picolinate | 2459-07-6 | 2A-9028574 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS