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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > Methyl 4-hydroxy-3-methoxycinnamate
Methyl 4-hydroxy-3-methoxycinnamate structure, CAS 2309-07-1

Methyl 4-hydroxy-3-methoxycinnamate

CAS Number2309-07-1

SynonymsFerulic acid methyl ester; Methyl (2E)-3-(4-hydroxy-3-methoxyphenyl)acrylate; ferulic acid amide; Ferulasaeure-amid; 2-Propenoic acid, 3- (4-hydroxy-3-methoxyphenyl)-, methyl ester; Ferulamid; Methyl ferulate; methyl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate; 4-Hydroxy-3-methoxy-zimtsaeure-amid; Methyl 4-hydroxy-3-methoxycinnamate; 4-Oxy-3-methoxy-zimtsaeure-amid; Ferulamide; 4-hydroxy-3-methoxy-cinnamic acid amide; 4-Hydroxy-3-Methoxycinnamide; methyl (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate; MFCD00017208; methyl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate; CINNAMIC ACID,4-HYDROXY-3-METHOXY-,METHYL ESTER; CINNAMAMIDE,4-HYDROXY-3-METHOXY; methyl 3-(4-hydroxy-3-methoxyphenyl)acrylate; Ferulic amide; feruloylamide; 3-(4-Hydroxy-3-methoxyphenyl)-2-propenamide

Molecular FormulaC11H12O4

Molecular Weight208.21

Purity98.00%

Density1.2±0.1 g/cm3

Boiling Point338.1±27.0 °C at 760 mmHg

Melting Point62-65°C

Flash Point

Appearance

EINECS

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Cat. No.: 2A-9028296 Purity: 98.00%
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Quality Control of [ 2309-07-1 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number2309-07-1
Catalog No.2A-9028296
Chinese Name阿魏酸甲酯
SynonymsFerulic acid methyl ester; Methyl (2E)-3-(4-hydroxy-3-methoxyphenyl)acrylate; ferulic acid amide; Ferulasaeure-amid; 2-Propenoic acid, 3- (4-hydroxy-3-methoxyphenyl)-, methyl ester; Ferulamid; Methyl ferulate; methyl (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate; 4-Hydroxy-3-methoxy-zimtsaeure-amid; Methyl 4-hydroxy-3-methoxycinnamate; 4-Oxy-3-methoxy-zimtsaeure-amid; Ferulamide; 4-hydroxy-3-methoxy-cinnamic acid amide; 4-Hydroxy-3-Methoxycinnamide; methyl (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate; MFCD00017208; methyl 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate; CINNAMIC ACID,4-HYDROXY-3-METHOXY-,METHYL ESTER; CINNAMAMIDE,4-HYDROXY-3-METHOXY; methyl 3-(4-hydroxy-3-methoxyphenyl)acrylate; Ferulic amide; feruloylamide; 3-(4-Hydroxy-3-methoxyphenyl)-2-propenamide
Molecular FormulaC11H12O4
Molecular Weight208.21
Purity98.00
Density1.2±0.1 g/cm3
Boiling Point338.1±27.0 °C at 760 mmHg
Melting Point62-65°C
Storage ConditionKeep container sealed, placed in a tight-fitting c
ApplicationFerulic acid methyl ester (Methyl ferulate) is a ferulic acid derivative isolated from Stemona tuberosa and has antioxidant and anti-inflammatory effects. Ferulic acid methyl ester can penetrate cell
HTC2918990090
PubChem ID116399
SMILESCOC(=O)/C=C/c1ccc(O)c(OC)c1
InChIInChI=1S/C11H12O4/c1-14-10-7-8(3-5-9(10)12)4-6-11(13)15-2/h3-7,12H,1-2H3/b6-4+
InChI KeyInChIKey=AUJXJFHANFIVKH-GQCTYLIASA-N
MSDSmsds/28296_1_2309_07_1.pdf
Use ofFerulic acid methyl ester (Methyl ferulate) is a derivative of ferulic acid, isolated from Stemona tuberosa, with anti-inflammatory and antioxidant properties[1][2]. Ferulic acid methyl ester is a cell membrane and brain permeable compound, shows free radical scavenging ability, used in the research of neurodegenerative disorders[1]. Ferulic acid methyl ester inhibits COX-2 expression, blocks p-p38 and p-JNK in primary bone marrow derived-macrophages[2]. Properties Name trans-methylferulate Synonym More Synonyms Methyl 4-hydroxy-3-methoxycinnamate Biological Activity Description Ferulic acid methyl ester (Methyl ferulate) is a derivative of ferulic acid, isolated from Stemona tuberosa, with anti-inflammatory and antioxidant properties[1][2]. Ferulic acid methyl ester is a cell membrane and brain permeable compound, shows free radical scavenging ability, used in the research of neurodegenerative disorders[1]. Ferulic acid methyl ester inhibits COX-2 expression, blocks p-p38 and p-JNK in primary bone marrow derived-macrophages[2]. Related Catalog Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease In Vitro Ferulic acid methyl ester (Methyl ferulate; 5, 10, 25 µg/mL) suppresses TNFα, IL6, IFNγ but not IL10, inhibits NO generation at 10 and 25 µg/mL, in primary bone marrow derived-macrophages (BMDMs)[2]. Ferulic acid methyl ester (25 µg/mL) inhibits COX-2 expression, blocks p-p38 and p-JNK[2]. References [1]. Sultana R. Ferulic acid ethyl ester as a potential therapy in neurodegenerative disorders. Biochim Biophys Acta. 2012 May;1822(5):748-52. [2]. Phuong NT, et al. Anti-inflammatory activity of methyl ferulate isolated from Stemona tuberosa Lour. Asian Pac J Trop Med. 2014 Sep;7S1:S327-31. Chemical & Physical Properties Molecular Formula C11H12O4 Exact Mass 208.073563 PSA 55.76000 Index of Refraction 1.575 Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Cinnamic acid, 4-hydroxy-3-methoxy-, methyl ester CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C11-H12-O4 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 25,187,1987 Safety Information Hazard Codes Xi RTECS GD9470000 HS Code 2918990090 Synthetic Route ferulic acid Methyl 4-hydrox... Literature: Bode; Doyle; Protopopova; Zhou Journal of Organic Chemistry, 1996 , vol. 61, # 26 p. 9146 - 9155 Methyl tripheny... 21204-67-1 Methyl 4-hydrox... Literature: Hafez, Taghrid S.; Henary, Maged M.; Mahran, Mohamed Refat H. Phosphorus, Sulfur and Silicon and Related Elements, 1998 , vol. 143, p. 33 - 44 ferulic acid Methyl 4-hydrox... Literature: Tetrahedron Letters, , vol. 25, # 26 p. 2755 - 2758 Precursor & DownStream Precursor 7 CAS#:67-56-1 CAS#:1135-24-6 ferulic acid CAS#:121-33-5 CAS#:186581-53-3 diazomethane DownStream 10 CAS#:3943-74-6 Methyl vanillate CAS#:121-33-5 CAS#:56024-44-3 Methyl 3-(4-Hyd... CAS#:458-35-5 Coniferyl alcohol
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 30.0%
Transport InfoProduct name: Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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