CAS Number2244-11-3
SynonymsMesoxalylcarbamide monohydrate; 2,4,5,6-Tetraoxohexahydropyrimidine hydrate; MFCD00149399; 2,4,5,6-Tetraoxypyrimidine; 2,4,5,6(1H,3H)-Pyrimidinetetrone hydrate; alloxan hydrate; 2,4,5,6(1H,3H)-Pyrimidinetetrone hydrate (1:1); ALLOXAN MONOHYDRATE; alloxane monohydrate; 1,3-dihydropyrimidine-2,4,5,6-tetraone,hydrate; 2,4,5,6(1H,3H)-Pyrimidinetetrone, hydrate (1:1); Alloxan-monohydrat; 5,6-Dioxyuracil; alloxane hydrate; Alloxan,monohydrate; Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate; EINECS 251-501-8; Pyrimidine-2,4,5,6(1H,3H)-tetrone hydrate (1:1)
Molecular FormulaC4H4N2O5
Molecular Weight160.085
Purity98.00%
Density1.681g/cm3
Boiling Point374.1ºC at 760 mmHg
Melting Point255 °C (dec.)(lit.)
AppearanceSolid;White to Light yellow powder to crystal
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2244-11-3 |
| Catalog No. | 2A-9028213 |
| Chinese Name | 阿脲,一水合物 |
| Synonyms | Mesoxalylcarbamide monohydrate; 2,4,5,6-Tetraoxohexahydropyrimidine hydrate; MFCD00149399; 2,4,5,6-Tetraoxypyrimidine; 2,4,5,6(1H,3H)-Pyrimidinetetrone hydrate; alloxan hydrate; 2,4,5,6(1H,3H)-Pyrimidinetetrone hydrate (1:1); ALLOXAN MONOHYDRATE; alloxane monohydrate; 1,3-dihydropyrimidine-2,4,5,6-tetraone,hydrate; 2,4,5,6(1H,3H)-Pyrimidinetetrone, hydrate (1:1); Alloxan-monohydrat; 5,6-Dioxyuracil; alloxane hydrate; Alloxan,monohydrate; Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate; EINECS 251-501-8; Pyrimidine-2,4,5,6(1H,3H)-tetrone hydrate (1:1) |
| Molecular Formula | C4H4N2O5 |
| Molecular Weight | 160.085 |
| Purity | 98.00 |
| Density | 1.681g/cm3 |
| Boiling Point | 374.1ºC at 760 mmHg |
| Melting Point | 255 °C (dec.)(lit.) |
| Appearance | Solid;White to Light yellow powder to crystal |
| Water Solubility | H2O: may be hazy yellow |
| Storage Condition | 2-8°C |
| Application | Alloxan hydrate is a diabetogenic drug that induces diabetes. Alloxan hydrate is a proteasome inhibitor. Alloxan causes diabetes in experimental animals through its ability to destroy the insulin-secr |
| HTC | 29335995 |
| PubChem ID | 3139123 |
| SMILES | O.O=C1NC(=O)C(=O)C(=O)N1 |
| InChI | InChI=1S/C4H2N2O4.H2O/c7-1-2(8)5-4(10)6-3(1)9;/h(H2,5,6,8,9,10);1H2 |
| InChI Key | DSXMTJRUNLATRP-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/28213_1_2244_11_3.pdf |
| Bioactivity | Alloxan hydrate is a diabetogenic agent to induce diabetes. Alloxan hydrate is a proteasome inhibitor. Alloxan causes diabetes in experimental animals through its ability to destroy the insulin-secreting B-cells of the pancreas[1][2]. Related Catalog Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome In Vitro Alloxan hydrate inhibits the peptidase activities of the purified 26S and 20S proteasomes[1]. References [1]. Zhou W, et al. Diabetogenic agent alloxan is a proteasome inhibitor. Biochem Biophys Res Commun. 2017;488(2):400-406. [2]. Munday R, et al. The relationship between the physicochemical properties and the biological effects of alloxan and several N-alkyl substituted alloxan derivatives. J Endocrinol. 1993;139(1):153-163. Chemical & Physical Properties Density 1.681g/cm3 Boiling Point 374.1ºC at 760 mmHg Melting Point 255 °C (dec.)(lit.) Molecular Formula C4H4N2O5 Molecular Weight 160.085 Flash Point 180ºC Exact Mass 160.012024 PSA 115.73000 Vapour Pressure 8.59E-07mmHg at 25°C InChIKey DSXMTJRUNLATRP-UHFFFAOYSA-N SMILES O.O=C1NC(=O)C(=O)C(=O)N1 Storage condition 2-8°C Water Solubility H2O: may be hazy yellow |
| Use of | Alloxan hydrate is a diabetogenic agent to induce diabetes. Alloxan hydrate is a proteasome inhibitor. Alloxan causes diabetes in experimental animals through its ability to destroy the insulin-secreting B-cells of the pancreas[1][2]. Properties Articles20 Name Alloxan monohydrate Synonym More Synonyms Biological Activity Description Alloxan hydrate is a diabetogenic agent to induce diabetes. Alloxan hydrate is a proteasome inhibitor. Alloxan causes diabetes in experimental animals through its ability to destroy the insulin-secreting B-cells of the pancreas[1][2]. Related Catalog Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome In Vitro Alloxan hydrate inhibits the peptidase activities of the purified 26S and 20S proteasomes[1]. References [1]. Zhou W, et al. Diabetogenic agent alloxan is a proteasome inhibitor. Biochem Biophys Res Commun. 2017;488(2):400-406. [2]. Munday R, et al. The relationship between the physicochemical properties and the biological effects of alloxan and several N-alkyl substituted alloxan derivatives. J Endocrinol. 1993;139(1):153-163. Chemical & Physical Properties Molecular Formula C4H4N2O5 Exact Mass 160.012024 PSA 115.73000 InChIKey DSXMTJRUNLATRP-UHFFFAOYSA-N SMILES O.O=C1NC(=O)C(=O)C(=O)N1 Water Solubility H2O: may be hazy yellow |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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