CAS Number2135-17-3
Synonyms6a-Fluorodexamethasone; (6α,11β,16α)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 6α-Fluorodexamethasone; 6α,9α-Difluoro-16α-methylprednisolone; Aniprime; Flumethasone; Fluvet; EINECS 218-370-9; flumetasone; 6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; Flucorticin; Anaprime; MFCD00056464; Flumethason; Cortexilar; 6a,9a-Difluoro-16a-methylprednisolone; Methagon
Molecular FormulaC22H28F2O5
Molecular Weight410.45
Purity98%
Density1.4±0.1 g/cm3
Boiling Point569.8±50.0 °C at 760 mmHg
Melting Point237-240ºC
Appearancepowder
EINECS218-370-9
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2135-17-3 |
| Catalog No. | 2A-9028029 |
| Chinese Name | 氟米松 |
| Synonyms | 6a-Fluorodexamethasone; (6α,11β,16α)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione; 6α-Fluorodexamethasone; 6α,9α-Difluoro-16α-methylprednisolone; Aniprime; Flumethasone; Fluvet; EINECS 218-370-9; flumetasone; 6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; Flucorticin; Anaprime; MFCD00056464; Flumethason; Cortexilar; 6a,9a-Difluoro-16a-methylprednisolone; Methagon |
| Molecular Formula | C22H28F2O5 |
| Molecular Weight | 410.45 |
| Purity | 98 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 569.8±50.0 °C at 760 mmHg |
| Melting Point | 237-240ºC |
| Appearance | powder |
| Storage Condition | 2-8°C |
| Application | Flumethasone is a corticosteroid, a topical drug used in combination with Clioquinol to treat otitis externa and otomycosis. When used in animal models, Flumethasone has 420 times higher anti-inflamma |
| EINECS | 218-370-9 |
| HTC | 2937229000 |
| PubChem ID | 24894998 |
| MDL Number | MFCD00056464 |
| SMILES | [H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C |
| InChI | 1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1 |
| InChI Key | WXURHACBFYSXBI-GQKYHHCASA-N |
| NACRES Code | NA.85 |
| UNSPSC | 51102829 |
| MSDS | msds/28029_1_2135_17_3.pdf |
| Use of | Flumethasone is a corticosteroid for topical use, in combination with Clioquinol for the treatment of otitis externa and otomycosis. Flumethasone shows fully 420 times the potency of cortisone in an animal model for anti-inflammatory activity. Properties Articles29 Name flumethasone Synonym More Synonyms Flumethasone Biological Activity Description Flumethasone is a corticosteroid for topical use, in combination with Clioquinol for the treatment of otitis externa and otomycosis. Flumethasone shows fully 420 times the potency of cortisone in an animal model for anti-inflammatory activity. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Chemical & Physical Properties Molecular Formula C22H28F2O5 Exact Mass 410.190491 PSA 94.83000 Index of Refraction 1.579 InChIKey WXURHACBFYSXBI-GQKYHHCASA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Pregna-1,4-diene-3,20-dione, 6-alpha,9-difluoro-11-beta,17,21-trihydroxy-16-alpha- methyl- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C22-H28-F2-O5 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SEX/DURATION : female 38 week(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 28,407,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SEX/DURATION : female 31 week(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- Volume(issue)/page/year: 160,867,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SEX/DURATION : female 40 week(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition REFERENCE : THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1974- Volume(issue)/page/year: 20,267,1983 Safety Information Signal Word Warning Hazard Statements H351 Precautionary Statements P281 Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges Hazard Codes Xn:Harmful Risk Phrases R40 Safety Phrases S22-S36 RIDADR NONH for all modes of transport WGK Germany 3 RTECS TU3832000 HS Code 2937229000 Synthetic Route Total: 1 Page 9beta,11beta-ep... CAS#:23961-95-7 Flumethasone CAS#:2135-17-3 Flumethasone 21... CAS#:2002-29-1 Flumethasone CAS#:2135-17-3 Literature: Farmaco, , vol. 51, # 12 p. 809 - 810 9β,11β-epoxy-6α... CAS#:4571-51-1 Flumethasone CAS#:2135-17-3 Precursor & DownStream Precursor 3 CAS#:23961-95-7 9beta,11beta-ep... CAS#:2002-29-1 Flumethasone 21... CAS#:4571-51-1 9β,11β-epoxy-6α... DownStream 2 CAS#:2607-06-9 Diflucortolone CAS#:28416-82-2 Flumethasone Acid |
| Transport Info | Product Name: Flumethasone |
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