CAS Number2078-54-8
Synonyms2,6-Bis(1-methylethyl)phenol (2,6-Bis(isopropyl)phenol; 2,6-i-Pr2-C6H3-OH; Diisopropylphenol; 2,6-di-iso-Propylphenol; 2,6-di(propan-2-yl)phenol; Propofolum; Disoprofol; 2-hydroxy-1,3-diisopropylbenzene; Fresofol; Diprivan; EINECS 218-206-6; Disoprivan; 2,6-Diisopropylphenol; 2,5-DIHYDRO-5-OXO-1-PHENYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID DIMETHYLAMIDE; MFCD00008885
Molecular Formula[(CH3)2CH]2C6H3OH
Molecular Weight178.27
Purity97%
Density0.9±0.1 g/cm3
Boiling Point256 °C/764 mmHg (lit.)
Melting Point18 °C (lit.)
Appearanceliquid
EINECS218-206-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2078-54-8 |
| Catalog No. | 2A-9027949 |
| Chinese Name | 丙泊酚 |
| Synonyms | 2,6-Bis(1-methylethyl)phenol (2,6-Bis(isopropyl)phenol; 2,6-i-Pr2-C6H3-OH; Diisopropylphenol; 2,6-di-iso-Propylphenol; 2,6-di(propan-2-yl)phenol; Propofolum; Disoprofol; 2-hydroxy-1,3-diisopropylbenzene; Fresofol; Diprivan; EINECS 218-206-6; Disoprivan; 2,6-Diisopropylphenol; 2,5-DIHYDRO-5-OXO-1-PHENYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID DIMETHYLAMIDE; MFCD00008885 |
| Molecular Formula | [(CH3)2CH]2C6H3OH |
| Molecular Weight | 178.27 |
| Purity | 97 |
| Density | 0.9±0.1 g/cm3 |
| Boiling Point | 256 °C/764 mmHg (lit.) |
| Melting Point | 18 °C (lit.) |
| Appearance | liquid |
| Storage Condition | Storage must be away from oxidants, stored in seal |
| Packaging | III |
| Application | Propofol potently and directly activates GABAA receptors and inhibits glutamate receptor-mediated excitatory synaptic transmission. Propofol has antinociceptive properties and can be used for sedation |
| EINECS | 218-206-6 |
| HTC | 2907199090 |
| PubChem ID | 24278001 |
| MDL Number | MFCD00008885 |
| SMILES | CC(C)c1cccc(C(C)C)c1O |
| InChI | 1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3 |
| InChI Key | OLBCVFGFOZPWHH-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/27949_1_2078_54_8.pdf |
| Bioactivity | Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor Target GABAA[1] In Vivo Propofol (i.p.; 40 mg/kg) causes full recovery from sedation occurred 36.3 mins. There is residual antinociception when assessed by ECT but not when assessed by noxious heat[1]. References [1]. R Nadeson, et al. Antinociceptive Properties of Propofol: Involvement of Spinal Cord Gamma-Aminobutyric acid(A) Receptors. J Pharmacol Exp Ther . 1997 Sep;282(3):1181-6. Chemical & Physical Properties Density 0.9±0.1 g/cm3 Boiling Point 256.0±0.0 °C at 760 mmHg Melting Point 18 °C(lit.) Molecular Formula C12H18O Molecular Weight 178.271 Flash Point 107.5±7.2 °C Exact Mass 178.135757 PSA 20.23000 LogP 4.16 Vapour Pressure 0.0±0.5 mmHg at 25°C Index of Refraction 1.513 InChIKey OLBCVFGFOZPWHH-UHFFFAOYSA-N SMILES CC(C)c1cccc(C(C)C)c1O Storage condition 0-6°C |
| Use of | Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic[1]. Properties Articles421 Name propofol Synonym More Synonyms Propofol Biological Activity Description Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission. Propofol has antinociceptive properties and is used for sedation and hypnotic[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor References [1]. R Nadeson, et al. Antinociceptive Properties of Propofol: Involvement of Spinal Cord Gamma-Aminobutyric acid(A) Receptors. J Pharmacol Exp Ther . 1997 Sep;282(3):1181-6. Chemical & Physical Properties Molecular Formula C12H18O Exact Mass 178.135757 PSA 20.23000 Index of Refraction 1.513 InChIKey OLBCVFGFOZPWHH-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 1230 International Maritime Transport Danger Regulations: 1230 International Air Transport Danger Regulations: 1230 14.2 United Nations shipping name European Land Transport Dangerous Regulations: METHANOL, solution IMDG Code: METHANOL, solution IFRS: Methanol, solution 14.3 Transport hazard categories European land transport risk code: 3 (6.1) International sea transport risk code: 3 (6.1) International air transport risk code: 3 (6.1) 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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