CAS Number1769-24-0
SynonymsEINECS 217-189-2; MFCD00006887; 2-methyl-4(3h)-quinazolinone
Molecular FormulaC9H8O1N2
Molecular Weight160.18
Purity98.00%
Density1.26 g/cm3
Boiling Point305.4ºC at 760 mmHg
Melting Point231-233ºC(lit.)
AppearanceSolid;White to Almost white powder to crystal
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1769-24-0 |
| Catalog No. | 2A-9027443 |
| Chinese Name | 2-甲基-4(1H)-喹唑啉酮 |
| Synonyms | EINECS 217-189-2; MFCD00006887; 2-methyl-4(3h)-quinazolinone |
| Molecular Formula | C9H8O1N2 |
| Molecular Weight | 160.18 |
| Purity | 98.00 |
| Density | 1.26 g/cm3 |
| Boiling Point | 305.4ºC at 760 mmHg |
| Melting Point | 231-233ºC(lit.) |
| Appearance | Solid;White to Almost white powder to crystal |
| Storage Condition | Store at room temperature in a cool and ventilated |
| Application | 2-Methylquinazolin-4-ol is a highly efficient and competitive poly(ADP-ribose) synthetase inhibitor with a Ki value of 1.1 μM. 2-Methylquinazolin-4-ol is a mammalian aspartate aminotransferase (ATCase |
| HTC | 2933990090 |
| PubChem ID | 69359 |
| MDL Number | MFCD05270928 |
| SMILES | CC1=NC(=O)c2ccccc2N1 |
| InChI | InChI=1S/C9H8N2O/c1-6-10-8-5-3-2-4-7(8)9(12)11-6/h2-5H,1H3,(H,10,11,12) |
| InChI Key | InChIKey=FIEYHAAMDAPVCH-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| MSDS | msds/27443_1_1769_24_0.pdf |
| Bioactivity | 2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM[1][2]. Related Catalog Signaling Pathways >> Epigenetics >> PARP Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> PARP In Vitro 2-Methylquinazolin-4-ol inhibits ATCase in a concentration-dependent manner[1]. In Vivo 2-Methylquinazolin-4-ol (0.2-1 mg; i.g.; for two days) inhibits ATCase in a dosedependent manner in vivo[2]. Animal Model: Mice[2] Dosage: 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 1 mg Administration: Oral gavage, for two days Result: Showed an inhibitory effect upon ATCase. References [1]. S Yoshida, et al. Production of 2-methyl-4[3H]-quinazolinone, an inhibitor of poly(ADP-ribose) synthetase, by bacterium. J Antibiot (Tokyo). 1991 Jan;44(1):111-2. [2]. Mahmoud Balbaa, et al. Inhibition of mammalian aspartate transcarbamylase by quinazolinone derivatives. J Enzyme Inhib Med Chem. 2008 Aug;23(4):483-92. Chemical & Physical Properties Density 1.26 g/cm3 Boiling Point 305.4ºC at 760 mmHg Melting Point 231-233ºC(lit.) Molecular Formula C9H8N2O Molecular Weight 160.17300 Flash Point 138.5ºC Exact Mass 160.06400 PSA 45.75000 LogP 1.23150 |
| Use of | Properties Name 2-Methylquinazolin-4-ol Synonym More Synonyms 2-Methylquinazolin-4-ol Biological Activity Related Catalog Signaling Pathways >> Epigenetics >> PARP Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> PARP In Vitro 2-Methylquinazolin-4-ol inhibits ATCase in a concentration-dependent manner[1]. References [1]. S Yoshida, et al. Production of 2-methyl-4[3H]-quinazolinone, an inhibitor of poly(ADP-ribose) synthetase, by bacterium. J Antibiot (Tokyo). 1991 Jan;44(1):111-2. [2]. Mahmoud Balbaa, et al. Inhibition of mammalian aspartate transcarbamylase by quinazolinone derivatives. J Enzyme Inhib Med Chem. 2008 Aug;23(4):483-92. Chemical & Physical Properties Molecular Formula C9H8N2O Exact Mass 160.06400 PSA 45.75000 LogP 1.23150 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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