| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1670-87-7 |
| Catalog No. | 2A-9027243 |
| Chinese Name | 1H-吲哚-5-甲酰胺 |
| Synonyms | 1H-Indole-5-carboxamide; indole-5-carboxamide |
| Molecular Formula | C9H8N2O |
| Molecular Weight | 160.17 |
| Purity | ≥97 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 457.6±18.0 °C at 760 mmHg |
| Melting Point | 159-163ºC |
| Appearance | solid |
| Storage Condition | 2-8°C, protected from light, dry and sealed |
| Application | SD-169 is an orally active ATP-competitive MAPK p38α inhibitor with an IC50 of 3.2 nM. SD-169 also has a weak inhibitory effect on p38β MAPK, with an IC50 value of 122 nM. SD-169 prevents the developm |
| HTC | 2933990090 |
| PubChem ID | 24885716 |
| MDL Number | MFCD07779486 |
| SMILES | [nH]1c2c(cc1)cc(cc2)C(=O)N |
| InChI | 1S/C9H8N2O/c10-9(12)7-1-2-8-6(5-7)3-4-11-8/h1-5,11H,(H2,10,12) |
| InChI Key | GQMYQEAXTITUAE-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 51111800 |
| Hazard Symbols | transportation |
| MSDS | msds/27243_1_1670_87_7.pdf |
| Bioactivity | SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation[1]. Related Catalog Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Metabolic Disease Target p38α MAPK:3.2 nM (IC50) p38β MAPK:122 nM (IC50) In Vitro SD-169 significantly reduces p38 and HSP60 expression in T cells of the pancreatic beta islets[1]. SD-169 demonstrates 38-fold potency against p38α MAP kinase (IC50=3.2 nM) than p38β MAP kinase (IC50=122 nM)[1]. References [1]. Medicherla S, et al. Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. J Pharmacol Exp Ther. 2006 Jul;318(1):99-107. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 457.6±18.0 °C at 760 mmHg Melting Point 159-163ºC Molecular Formula C9H8N2O Molecular Weight 160.173 Flash Point 230.6±21.2 °C Exact Mass 160.063660 PSA 58.88000 LogP 0.88 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.717 InChIKey GQMYQEAXTITUAE-UHFFFAOYSA-N SMILES NC(=O)c1ccc2[nH]ccc2c1 |
| Use of | SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation[1]. Properties Name 1H-Indole-5-carboxamide Synonym More Synonyms SD-169 Biological Activity Description SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation[1]. Related Catalog Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Metabolic Disease p38α MAPK:3.2 nM (IC50) p38β MAPK:122 nM (IC50) In Vitro SD-169 significantly reduces p38 and HSP60 expression in T cells of the pancreatic beta islets[1]. SD-169 demonstrates 38-fold potency against p38α MAP kinase (IC50=3.2 nM) than p38β MAP kinase (IC50=122 nM)[1]. References [1]. Medicherla S, et al. Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. J Pharmacol Exp Ther. 2006 Jul;318(1):99-107. Chemical & Physical Properties Molecular Formula C9H8N2O Exact Mass 160.063660 PSA 58.88000 Index of Refraction 1.717 InChIKey GQMYQEAXTITUAE-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 97.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available The company is not responsible for any damage caused by any operation or contact with the above products. For more terms of use, see invoice or package The reverse side of the mounting strip. |
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