CAS Number1670-14-0
SynonymsBENZAMIDE HCL H2O; benzenecarboximidamide hydrochloride; EINECS 216-795-4; benzamidinium chloride; benzamidine-hydrochloride; Benzamidine hydrochloride; BENZAMIDINE HCL; 2-phenylamidine hydrochloride; Benzenecarboximidamide hydrochloride (1:1); benzamidine hydroxychloride; Benzamidine hydrochl; MFCD00013025; Additive Screening; Benzamidine monohydrochloride; AMIDINOBENZENE HYDROCHLORIDE; amidinobenzenehydrochloride; Benzamidin Hydrochloride; Amidinobenzene hydrochloride (1:1); Benzenecarboximidamide, hydrochloride (1:1); Benzimidamide hydrochloride; phenyl amidine hydrochloride
Molecular FormulaC6H5C(=NH)NH2 · HCl
Molecular Weight156.61
Purity99%
Density1.09 g/cm3
Boiling Point332.9ºC at 760 mmHg
Melting Point169-173 °C (lit.)
Appearancebeads
EINECS216-795-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1670-14-0 |
| Catalog No. | 2A-9027238 |
| Chinese Name | 苄脒盐酸盐 |
| Synonyms | BENZAMIDE HCL H2O; benzenecarboximidamide hydrochloride; EINECS 216-795-4; benzamidinium chloride; benzamidine-hydrochloride; Benzamidine hydrochloride; BENZAMIDINE HCL; 2-phenylamidine hydrochloride; Benzenecarboximidamide hydrochloride (1:1); benzamidine hydroxychloride; Benzamidine hydrochl; MFCD00013025; Additive Screening; Benzamidine monohydrochloride; AMIDINOBENZENE HYDROCHLORIDE; amidinobenzenehydrochloride; Benzamidin Hydrochloride; Amidinobenzene hydrochloride (1:1); Benzenecarboximidamide, hydrochloride (1:1); Benzimidamide hydrochloride; phenyl amidine hydrochloride |
| Molecular Formula | C6H5C(=NH)NH2 · HCl |
| Molecular Weight | 156.61 |
| Purity | 99 |
| Density | 1.09 g/cm3 |
| Boiling Point | 332.9ºC at 760 mmHg |
| Melting Point | 169-173 °C (lit.) |
| Appearance | beads |
| Water Solubility | soluble |
| Storage Condition | Keep container sealed and store in a cool, dry pla |
| Application | Benzamidine hydrochloride is a reversible, competitive inhibitor of trypsin-like serine proteases with Ki values of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectiv |
| EINECS | 216-795-4 |
| HTC | 2925290090 |
| PubChem ID | 24867207 |
| MDL Number | MFCD00013025 |
| SMILES | Cl.NC(=N)c1ccccc1 |
| InChI | 1S/C7H8N2.ClH/c8-7(9)6-4-2-1-3-5-6;/h1-5H,(H3,8,9);1H |
| InChI Key | LZCZIHQBSCVGRD-UHFFFAOYSA-N |
| Beilstein/REAXYS | 3594959 |
| NACRES Code | NA.77 |
| UNSPSC | 12352106 |
| Hazard Symbols | transportation |
| MSDS | msds/27238_1_1670_14_0.pdf |
| Bioactivity | Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively[1]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cancer Target Ki: 97 µM (uPA), 21 µM (trypsin), 20 µM (tryptase), 110 µM (factor Xa)[1] In Vitro Benzamidine hydrochloride has weak inhibition for tPA and thrombin, with Kis of 750 µM and 320 µM, respectively[1]. References [1]. Tanizawa K, et al. Proteolytic enzymes. VI. Aromatic amidines as competitive inhibitors of trypsin. J Biochem. 1971 May;69(5):893-9. [2]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312. Chemical & Physical Properties Density 1.09 g/cm3 Boiling Point 332.9ºC at 760 mmHg Melting Point 86-88 °C(lit.) Molecular Formula C7H9ClN2 Molecular Weight 156.613 Flash Point 155.1ºC Exact Mass 156.045425 PSA 49.87000 LogP 2.57270 Vapour Pressure 5.63E-05mmHg at 25°C InChIKey LZCZIHQBSCVGRD-UHFFFAOYSA-N SMILES Cl.N=C(N)c1ccccc1 Water Solubility soluble |
| Use of | Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively[1]. Properties Articles41 Name Benzamidine hydrochloride Synonym More Synonyms Benzimidamide hydrochloride Biological Activity Description Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively[1]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cancer Ki: 97 µM (uPA), 21 µM (trypsin), 20 µM (tryptase), 110 µM (factor Xa)[1] In Vitro Benzamidine hydrochloride has weak inhibition for tPA and thrombin, with Kis of 750 µM and 320 µM, respectively[1]. References [1]. Tanizawa K, et al. Proteolytic enzymes. VI. Aromatic amidines as competitive inhibitors of trypsin. J Biochem. 1971 May;69(5):893-9. [2]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312. Chemical & Physical Properties Exact Mass 156.045425 PSA 49.87000 LogP 2.57270 InChIKey LZCZIHQBSCVGRD-UHFFFAOYSA-N Water Solubility soluble |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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