CAS Number1638-41-1
Synonyms2,2'-Sulfonylbis(3,4,6-trichlorophenol); Bis-(3,5,6-Trichlor-2-hydroxyphenyl)-sulfon; Bis-(3,5,6-trichlor-2-hydroxyphenyl)sulfid
Molecular FormulaC12H4Cl6O4S
Molecular Weight456.94
Purity98.00%
Density1.854 g/cm3
Boiling Point590ºC at 760 mmHg
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1638-41-1 |
| Catalog No. | 2A-9027186 |
| Chinese Name | 2,2'-磺酰基双(3,4,6-三氯苯酚) |
| Synonyms | 2,2'-Sulfonylbis(3,4,6-trichlorophenol); Bis-(3,5,6-Trichlor-2-hydroxyphenyl)-sulfon; Bis-(3,5,6-trichlor-2-hydroxyphenyl)sulfid |
| Molecular Formula | C12H4Cl6O4S |
| Molecular Weight | 456.94 |
| Purity | 98.00 |
| Density | 1.854 g/cm3 |
| Boiling Point | 590ºC at 760 mmHg |
| Storage Condition | -20°C, sealed, dry |
| Application | p38 MAP kinase inhibitor IV is a highly specific ATP-competitive inhibitor of p38αMAPK, with IC50s of p38α and p38βMAPK being 0.13 and 0.55μM respectively [1]. |
| HTC | 2908999090 |
| PubChem ID | 5469412 |
| SMILES | O=S(=O)(c1c(O)c(Cl)cc(Cl)c1Cl)c1c(O)c(Cl)cc(Cl)c1Cl |
| InChI | InChI=1S/C12H4Cl6O4S/c13-3-1-5(15)9(19)11(7(3)17)23(21,22)12-8(18)4(14)2-6(16)10(12)20/h1-2,19-20H |
| InChI Key | AKUKHICVNCCQHN-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | p38 MAP Kinase Inhibitor IV is a highly specific ATP-competitive p38α MAPK inhibitor with IC50s of 0.13 and 0.55 μM for p38α and p38β MAPK, respectively[1]. Related Catalog Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology Target p38α:0.13 μM (IC50) p38β:0.55 μM (IC50) p38δ:8.63 μM (IC50) p38χ:5.47 μM (IC50) In Vitro p38 MAP Kinase Inhibitor IV (MT4) shows IC50 values of 0.13, 0.55, 5.47, and 8.63μM for p38α, β, χ, andδ, respectively. p38 MAP Kinase Inhibitor IV has the suppressive action on the release of TNF-alpha and IL-1beta in PBMC with IC50 values of 22 and 44 nM, respectively[1]. References [1]. Liu YC, et al. Identification of a novel competitive inhibitor of p38alpha MAPK by a human PBMC screen. Biochem Biophys Res Commun. 2007;352(3):656-661. Chemical & Physical Properties Density 1.854 g/cm3 Boiling Point 590ºC at 760 mmHg Molecular Formula C12H4Cl6O4S Molecular Weight 456.94100 Flash Point 310.6ºC Exact Mass 453.79600 PSA 82.98000 LogP 6.93180 InChIKey AKUKHICVNCCQHN-UHFFFAOYSA-N SMILES O=S(=O)(c1c(O)c(Cl)cc(Cl)c1Cl)c1c(O)c(Cl)cc(Cl)c1Cl |
| Use of | p38 MAP Kinase Inhibitor IV is a highly specific ATP-competitive p38α MAPK inhibitor with IC50s of 0.13 and 0.55 μM for p38α and p38β MAPK, respectively[1]. Properties Name phenol,2,2'-sulfonylbis[3,4,6-trichloro] Synonym More Synonyms p38 MAP Kinase Inhibitor IV Biological Activity Description p38 MAP Kinase Inhibitor IV is a highly specific ATP-competitive p38α MAPK inhibitor with IC50s of 0.13 and 0.55 μM for p38α and p38β MAPK, respectively[1]. Related Catalog Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology p38α:0.13 μM (IC50) p38β:0.55 μM (IC50) p38δ:8.63 μM (IC50) p38χ:5.47 μM (IC50) In Vitro p38 MAP Kinase Inhibitor IV (MT4) shows IC50 values of 0.13, 0.55, 5.47, and 8.63μM for p38α, β, χ, andδ, respectively. p38 MAP Kinase Inhibitor IV has the suppressive action on the release of TNF-alpha and IL-1beta in PBMC with IC50 values of 22 and 44 nM, respectively[1]. References [1]. Liu YC, et al. Identification of a novel competitive inhibitor of p38alpha MAPK by a human PBMC screen. Biochem Biophys Res Commun. 2007;352(3):656-661. Chemical & Physical Properties Exact Mass 453.79600 PSA 82.98000 LogP 6.93180 InChIKey AKUKHICVNCCQHN-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Tetrabutylthiuram disulfide | 1634-02-2 | 2A-9027176 |
| 2-(4-Hydroxyphenylazo)benzoic acid | 1634-82-8 | 2A-9027179 |
| 3-Amino-2H-chromen-2-one | 1635-31-0 | 2A-9027180 |
| trans-Zeatin | 1637-39-4 | 2A-9027183 |
| Isocitric acid trisodium salt | 1637-73-6 | 2A-9027184 |
| 2-Acetoxy-2-phenylacetyl chloride | 1638-63-7 | 2A-9027187 |
| 1-Heptanethiol | 1639-09-4 | 2A-9027188 |
| Nicametate citrate | 1641-74-3 | 2A-9027192 |
| 3-(4-Bromophenyl)propionic acid | 1643-30-7 | 2A-9027198 |
| 3-(Perfluorooctyl)propan-1-ol | 1651-41-8 | 2A-9027205 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS