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Cholesteryl hemisuccinate structure, CAS 1510-21-0

Cholesteryl hemisuccinate

CAS Number1510-21-0

Synonyms4-[(3β)-Cholest-5-en-3-yloxy]-4-oxobutanoic acid; 3-cholesteryloxycarbonylpropanoic acid; Cholesteryl hydrogen succinate; EINECS 216-148-6; 3-(3-cholesteryloxycarbonyl)propanoic acid; MONO-CHOLESTERYL-SUCCINATE; CHOLESTEROL HYDROGEN SUCCINATE; 3β-Hydroxy-5-cholestene 3-hemisuccinate; MFCD00037705; cholesteryl hemisuccinate free acid; cholesterylsuccinate; 5-Cholesten-3β-ol 3-hemisuccinate; Succinic Acid Monocholesterol Ester; 5-CHOLESTEN-3BETA-OL 3-HEMISUCCINATE; Butanedioic acid, mono[(3β)-cholest-5-en-3-yl] ester

Molecular FormulaC31H50O4

Molecular Weight486.73

Purity98.00%

Density1.1±0.1 g/cm3

Boiling Point586.0±43.0 °C at 760 mmHg

Melting Point178 °C

Flash Point

Appearanceliquid crystal

EINECS216-148-6

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Cat. No.: 2A-9026948 Purity: 98.00%
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Quality Control of [ 1510-21-0 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number1510-21-0
Catalog No.2A-9026948
Chinese Name胆固醇琥珀酸单酯
Synonyms4-[(3β)-Cholest-5-en-3-yloxy]-4-oxobutanoic acid; 3-cholesteryloxycarbonylpropanoic acid; Cholesteryl hydrogen succinate; EINECS 216-148-6; 3-(3-cholesteryloxycarbonyl)propanoic acid; MONO-CHOLESTERYL-SUCCINATE; CHOLESTEROL HYDROGEN SUCCINATE; 3β-Hydroxy-5-cholestene 3-hemisuccinate; MFCD00037705; cholesteryl hemisuccinate free acid; cholesterylsuccinate; 5-Cholesten-3β-ol 3-hemisuccinate; Succinic Acid Monocholesterol Ester; 5-CHOLESTEN-3BETA-OL 3-HEMISUCCINATE; Butanedioic acid, mono[(3β)-cholest-5-en-3-yl] ester
Molecular FormulaC31H50O4
Molecular Weight486.73
Purity98.00
Density1.1±0.1 g/cm3
Boiling Point586.0±43.0 °C at 760 mmHg
Melting Point178 °C
Appearanceliquid crystal
Storage ConditionKeep the container sealed and stored in a cool, dr
ApplicationCholesterol hemisuccinate is a substance with liver-protective and anti-cancer activity. Cholesterol hemisuccinate inhibits the hepatotoxicity of acetaminophen (AAP, HY-66005) and prevents AAP-induced
EINECS216-148-6
PubChem ID24892873
MDL NumberMFCD00037705
SMILES[H][C@@]([C@H](C)CCCC(C)C)([C@@]1(C)CC[C@@]23[H])CC[C@]1([C@](CC=C4C[C@H](CC[C@]34C)OC(CCC(O)=O)=O)2[H])[H]
InChI1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1
InChI KeyWLNARFZDISHUGS-MIXBDBMTSA-N
NACRES CodeNA.23
UNSPSC12352103
Hazard Symbolstransportation
MSDSmsds/26948_1_1510_21_0.pdf
BioactivityCholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis In Vivo Cholesteryl hemisuccinate (100 mg/kg; ip; single dose before AAP) Eliminates AAP (350-500 mg/kg; ip; single dose) Histological and biochemical diagnosis of apoptosis and necrosis induced in ICR mice (CD-1) [1]. References [1]. Ray SD, et al. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther. 1996 Dec;279(3):1470-83. [2]. Varshosaz J, et al. Folated synperonic-cholesteryl hemisuccinate polymeric micelles for the targeted delivery of docetaxel in melanoma. Biomed Res Int. 2015;2015:746093. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 586.0±43.0 °C at 760 mmHg Melting Point 178 °C Molecular Formula C31H50O4 Molecular Weight 486.73 Flash Point 179.6±21.7 °C Exact Mass 486.370911 PSA 63.60000 LogP 10.32 Vapor Pressure 0.0±3.5 mmHg at 25°C Index of Refraction 1.529 InChIKey WLNARFZDISHUGS-MIXBDBMTSA-N SMILES CC(C)CCCC(C)C1CCC2C3CC=C4CC(OC(=O)CCC(=O)O)CCC4(C)C3CCC12C
Use ofCholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth[1][2]. Properties Articles47 Name Cholesteryl hemisuccinate Synonym More Synonyms Biological Activity Description Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis References [1]. Ray SD, et al. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther. 1996 Dec;279(3):1470-83. [2]. Varshosaz J, et al. Folated synperonic-cholesteryl hemisuccinate polymeric micelles for the targeted delivery of docetaxel in melanoma. Biomed Res Int. 2015;2015:746093. Chemical & Physical Properties Molecular Formula C31H50O4 Exact Mass 486.370911 PSA 63.60000 LogP 10.32 Index of Refraction 1.529 InChIKey WLNARFZDISHUGS-MIXBDBMTSA-N
Transport InfoProduct name: Purity: 97.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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