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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > 3,4-Methylenedioxy-beta-nitrostyrene
3,4-Methylenedioxy-beta-nitrostyrene structure, CAS 1485-00-3

3,4-Methylenedioxy-beta-nitrostyrene

CAS Number1485-00-3

Synonyms3,4-Methylenedioxy-β-nitrostyrene; 5-[(E)-2-Nitrovinyl]-1,3-benzodioxole; T56 BO DO CHJ G1U1NW; MFCD00014575; 5-(2-Nitrovinyl)benzo[d][1,3]dioxole; MNS

Molecular FormulaC9H7NO4

Molecular Weight193.16

Purity≥98 (GC)%

Density1.4±0.1 g/cm3

Boiling Point334.9±11.0 °C at 760 mmHg

Melting Point159-163 °C

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-9026914 Purity: ≥98 (GC)%
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Quality Control of [ 1485-00-3 ] Purity: ≥98 (GC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number1485-00-3
Catalog No.2A-9026914
Chinese NameMNS
Synonyms3,4-Methylenedioxy-β-nitrostyrene; 5-[(E)-2-Nitrovinyl]-1,3-benzodioxole; T56 BO DO CHJ G1U1NW; MFCD00014575; 5-(2-Nitrovinyl)benzo[d][1,3]dioxole; MNS
Molecular FormulaC9H7NO4
Molecular Weight193.16
Purity≥98 (GC)
Density1.4±0.1 g/cm3
Boiling Point334.9±11.0 °C at 760 mmHg
Melting Point159-163 °C
Appearancesolid
Storage ConditionKeep the container sealed and stored in a cool, dr
ApplicationMNS is a strong, selective Src and Syk tyrosine kinase.
HTC2932999099
PubChem ID3145558
MDL NumberMFCD00014575
SMILES[N+](=O)([O-])\C=C/c1cc2c(cc1)OCO2
InChI1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3-
InChI KeyKFLWBZPSJQPRDD-ARJAWSKDSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard Symbolstransportation
MSDSmsds/26914_1_1485_00_3.pdf
BioactivityMNS is a potent and selective inhibitor of Src and Syk tyrosine kinases. target: src, syk. [1]IC50:29.3 (src), 2.5 uM (syk); [1]In vitro: no direct effects on protein kinase C, Ca2+ mobilization, Ca2+-dependent enzymes, PKC activation. MNS potently prevents GPIIb/IIIa activation and platelet aggregation without directly affecting other signaling pathways required for platelet activation. [1] [2] MNS is much more potent than genistein in inhibiting platelet aggregation and protein tyrosine phosphorylation. [2] Related Catalog Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Syk Research Areas >> Cancer References [1]. Wang WY et al. Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-beta-nitrostyrene, a novel tyrosinekinase inhibitor. Mol Pharmacol. 2006 Oct;70(4):1380-9. [2]. Wang WY et al. Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitorswith potent antiplatelet activity. Biochem Pharmacol. 2007 Aug 15;74(4):601-11. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 334.9±11.0 °C at 760 mmHg Melting Point 159-163 °C Molecular Formula C9H7NO4 Molecular Weight 193.156 Flash Point 168.8±21.3 °C Exact Mass 193.037506 PSA 64.28000 LogP 2.27 Vapour Pressure 0.0±0.7 mmHg at 25°C Index of Refraction 1.640 Storage condition Store at +4°C
Use ofMNS is a potent and selective inhibitor of Src and Syk tyrosine kinases. target: src, syk. [1]IC50:29.3 (src), 2.5 uM (syk); [1]In vitro: no direct effects on protein kinase C, Ca2+ mobilization, Ca2+-dependent enzymes, PKC activation. MNS potently prevents GPIIb/IIIa activation and platelet aggregation without directly affecting other signaling pathways required for platelet activation. [1] [2] MNS is much more potent than genistein in inhibiting platelet aggregation and protein tyrosine phosphorylation. [2] Properties Name 3,4-Methylenedioxy-beta-nitrostyrene Synonym More Synonyms MDBN Biological Activity Description MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases. target: src, syk. [1]IC50:29.3 (src), 2.5 uM (syk); [1]In vitro: no direct effects on protein kinase C, Ca2+ mobilization, Ca2+-dependent enzymes, PKC activation. MNS potently prevents GPIIb/IIIa activation and platelet aggregation without directly affecting other signaling pathways required for platelet activation. [1] [2] MNS is much more potent than genistein in inhibiting platelet aggregation and protein tyrosine phosphorylation. [2] Related Catalog Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Syk Research Areas >> Cancer References [1]. Wang WY et al. Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-beta-nitrostyrene, a novel tyrosinekinase inhibitor. Mol Pharmacol. 2006 Oct;70(4):1380-9. [2]. Wang WY et al. Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitorswith potent antiplatelet activity. Biochem Pharmacol. 2007 Aug 15;74(4):601-11. Chemical & Physical Properties Molecular Formula C9H7NO4 Exact Mass 193.037506 PSA 64.28000 Index of Refraction 1.640
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (3,4-Methylenedioxy-β-nitrostyrene) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (3,4-Methylenedioxy-β-nitrostyrene) International air transport hazard regulations: Toxic solid, organic, n.o.s. (3,4-Methylenedioxy-β-nitrostyrene) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
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