CAS Number1477-19-6
Synonyms(2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone; Fragivix; Benzarone; (2-ETHYL-1-BENZOFURAN-3-YL)(4-HYDROXYPHENYL)METHANONE; Fagivil; Vasoc; Fragivil; Benzaron; Venagil
Molecular FormulaC17H14O3
Molecular Weight266.29
Purity98.00%
Density1.234g/cm3
Boiling Point473.6ºC at 760mmHg
Melting Point124.3°
AppearanceSolid;White to Almost white powder to crystal
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1477-19-6 |
| Catalog No. | 2A-9026884 |
| Chinese Name | 苯扎隆 |
| Synonyms | (2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone; Fragivix; Benzarone; (2-ETHYL-1-BENZOFURAN-3-YL)(4-HYDROXYPHENYL)METHANONE; Fagivil; Vasoc; Fragivil; Benzaron; Venagil |
| Molecular Formula | C17H14O3 |
| Molecular Weight | 266.29 |
| Purity | 98.00 |
| Density | 1.234g/cm3 |
| Boiling Point | 473.6ºC at 760mmHg |
| Melting Point | 124.3° |
| Appearance | Solid;White to Almost white powder to crystal |
| Water Solubility | Soluble in: methanol |
| Storage Condition | Ventilated, low-temperature drying, stored separat |
| Application | Benzalone (Fragivix) is a potent inhibitor of human urate transporter 1 (hURAT1) with an IC50 of 2.8 μM in oocytes. Benzalone can reduce serum uric acid levels [1]. |
| HTC | 2932999099 |
| PubChem ID | 120878 |
| MDL Number | MFCD00867417 |
| SMILES | [o]1c2c(c(c1CC)C(=O)c3ccc(cc3)O)cccc2 |
| InChI | 1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3 |
| InChI Key | RFRXIWQYSOIBDI-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | transportation |
| MSDS | msds/26884_1_1477_19_6.pdf |
| Bioactivity | Benzarone (Fragivix) is a potent human uric acid transporter 1 (hURAT1) inhibitor, with an IC50 of 2.8 μM in oocyte. Benzarone could lower uric acid serum levels[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> URAT1 Research Areas >> Metabolic Disease Target IC50: 2.8 μM (hURAT1 in oocyte)[1] References [1]. Wempe MF, et, al. Developing potent human uric acid transporter 1 (hURAT1) inhibitors. J Med Chem. 2011 Apr 28;54(8):2701-13. Chemical & Physical Properties Density 1.234g/cm3 Boiling Point 473.6ºC at 760mmHg Melting Point 124.3° Molecular Formula C17H14O3 Molecular Weight 266.29100 Flash Point 240.2ºC Exact Mass 266.09400 PSA 50.44000 LogP 3.93180 Vapour Pressure 1.36E-09mmHg at 25°C Index of Refraction 1.638 InChIKey RFRXIWQYSOIBDI-UHFFFAOYSA-N SMILES CCc1oc2ccccc2c1C(=O)c1ccc(O)cc1 |
| Use of | Benzarone (Fragivix) is a potent human uric acid transporter 1 (hURAT1) inhibitor, with an IC50 of 2.8 μM in oocyte. Benzarone could lower uric acid serum levels[1]. Properties Articles25 Name (2-ethyl-1-benzofuran-3-yl)-(4-hydroxyphenyl)methanone Synonym More Synonyms Benzarone Biological Activity Description Benzarone (Fragivix) is a potent human uric acid transporter 1 (hURAT1) inhibitor, with an IC50 of 2.8 μM in oocyte. Benzarone could lower uric acid serum levels[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> URAT1 Research Areas >> Metabolic Disease IC50: 2.8 μM (hURAT1 in oocyte)[1] References [1]. Wempe MF, et, al. Developing potent human uric acid transporter 1 (hURAT1) inhibitors. J Med Chem. 2011 Apr 28;54(8):2701-13. Chemical & Physical Properties Molecular Formula C17H14O3 Exact Mass 266.09400 PSA 50.44000 LogP 3.93180 Index of Refraction 1.638 InChIKey RFRXIWQYSOIBDI-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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