CAS Number1447-88-7
SynonymsDinatin; Scutellarein 6-methyl ether; 6-O-Methylapigenin; TCMDC-123942; 4',5,7-Trihydroxy-6-methoxyflavone; 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxychromen-4-one; Hispidulin; 6-O-Methoxyapigenin; 5,7,4'-trihydroxy-6-methoxyflavone; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one
Molecular FormulaC16H12O6
Molecular Weight300.26
Purity98.00%
Density1.5±0.1 g/cm3
Boiling Point601.5±55.0 °C at 760 mmHg
Appearancewhite to beige
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1447-88-7 |
| Catalog No. | 2A-9026813 |
| Chinese Name | 高车前素 |
| Synonyms | Dinatin; Scutellarein 6-methyl ether; 6-O-Methylapigenin; TCMDC-123942; 4',5,7-Trihydroxy-6-methoxyflavone; 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxychromen-4-one; Hispidulin; 6-O-Methoxyapigenin; 5,7,4'-trihydroxy-6-methoxyflavone; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one |
| Molecular Formula | C16H12O6 |
| Molecular Weight | 300.26 |
| Purity | 98.00 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 601.5±55.0 °C at 760 mmHg |
| Appearance | white to beige |
| Water Solubility | DMSO: soluble20mg/mL, clear |
| Storage Condition | Desiccate at -20°C |
| Application | Hispidulin is a natural flavonoid with a wide range of biological activities. Hispidulin is an inhibitor of Pim-1 with an IC50 value of 2.71 μM. |
| HTC | 2914509090 |
| PubChem ID | 12244 |
| SMILES | COc1c(O)cc2oc(-c3ccc(O)cc3)cc(=O)c2c1O |
| InChI | InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3 |
| InChI Key | IHFBPDAQLQOCBX-UHFFFAOYSA-N |
| Use of | Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM. Properties Articles25 Name hispidulin Synonym More Synonyms Hispidulin Biological Activity Description Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM. Related Catalog Signaling Pathways >> JAK/STAT Signaling >> Pim Research Areas >> Cancer Natural Products >> Flavonoids IC50: 2.71 μM (Pim-1)[1] References [1]. Chao SW, et al. Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene KinasePim-1. J Nat Prod. 2015 Aug 28;78(8):1969-76. [3]. Zhou R, et al. Hispidulin exerts anti-osteoporotic activity in ovariectomized mice via activating AMPK signaling pathway. Cell Biochem Biophys. 2014 Jun;69(2):311-7. [4]. Lin TY, et al. Protective effect of hispidulin on kainic acid-induced seizures and neurotoxicity in rats. Eur J Pharmacol. 2015 May 15;755:6-15. Chemical & Physical Properties Molecular Formula C16H12O6 Exact Mass 300.063385 PSA 100.13000 Appearance of Characters white to beige Index of Refraction 1.697 InChIKey IHFBPDAQLQOCBX-UHFFFAOYSA-N Safety Information Signal Word Warning Hazard Statements H302 Hazard Codes Xn Risk Phrases 22 RIDADR NONH for all modes of transport RTECS DJ2996000 HS Code 2914509090 Synthetic Route Xanthoxylin Hispidulin Literature: British Journal of Pharmacology, , vol. 142, # 5 p. 811 - 820 4-(benzyloxy)be... Hispidulin Literature: British Journal of Pharmacology, , vol. 142, # 5 p. 811 - 820 2',4',6... Hispidulin Literature: British Journal of Pharmacology, , vol. 142, # 5 p. 811 - 820 Precursor & DownStream Precursor 10 CAS#:90-24-4 Xanthoxylin CAS#:1486-50-6 4-(benzyloxy)be... CAS#:480-66-0 2',4',6'-Trihyd... CAS#:25892-95-9 4'-Benzyloxy-6'... DownStream 2 CAS#:1061-93-4 [2-acetyloxy-4-... CAS#:529-53-3 Scutellarein |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| 2-Dimethylaminoethyl acetate | 1421-89-2 | 2A-9026775 |
| Ethylenebis(nitrilodimethylene)tetraphosphonic acid | 1429-50-1 | 2A-9026787 |
| 3-Acetyl-2-oxazolidinone | 1432-43-5 | 2A-9026788 |
| 4-Methyl-2-(2'-nitrophenyl)azophenol | 1435-71-8 | 2A-9026797 |
| Furfuryl methyl sulfide | 1438-91-1 | 2A-9026800 |
| Methyl cholate | 1448-36-8 | 2A-9026814 |
| N-(2-Cyanoacetyl)urea | 1448-98-2 | 2A-9026816 |
| 2-Hydroxy-5-nitroacetophenone | 1450-76-6 | 2A-9026824 |
| 2,5-Dibromopentanoic acid | 1450-81-3 | 2A-9026825 |
| 2-Bromo-4'-methylpropiophenone | 1451-82-7 | 2A-9026828 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS