CAS Number1202-66-0
SynonymsGNF-PF-5230; N-Acetyltyramine; N-acetyltyramin; N-[2-(4-Hydroxyphenyl)ethyl]acetamide
Molecular FormulaC10H13NO2
Molecular Weight179.22
Purity≥95 (LC/MS-ELSD)%
Density1.1±0.1 g/cm3
Boiling Point424.1±28.0 °C at 760 mmHg
Melting Point134°C
Appearancesolid
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1202-66-0 |
| Catalog No. | 2A-9026488 |
| Chinese Name | N-(4-羟基苯基)乙酰胺 |
| Synonyms | GNF-PF-5230; N-Acetyltyramine; N-acetyltyramin; N-[2-(4-Hydroxyphenyl)ethyl]acetamide |
| Molecular Formula | C10H13NO2 |
| Molecular Weight | 179.22 |
| Purity | ≥95 (LC/MS-ELSD) |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 424.1±28.0 °C at 760 mmHg |
| Melting Point | 134°C |
| Appearance | solid |
| Storage Condition | 2-8°C |
| Application | N-Acetyltyramine is a quorum sensing inhibitor (QSI) compound produced by Vibrio alginolyticus M3-10. N-Acetyltyramine inhibits quorum sensing (QS) of C. violaceum ATCC 12472. N-Acetyltyramine reverse |
| HTC | 2924299090 |
| PubChem ID | 329824672 |
| MDL Number | MFCD01670887 |
| SMILES | N(CCc1ccc(cc1)O)C(=O)C |
| InChI | 1S/C10H13NO2/c1-8(12)11-7-6-9-2-4-10(13)5-3-9/h2-5,13H,6-7H2,1H3,(H,11,12) |
| InChI Key | ATDWJOOPFDQZNK-UHFFFAOYSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352205 |
| MSDS | msds/26488_1_1202_66_0.pdf |
| Bioactivity | N-Acetyltyramine is a quorum-sensing inhibitor (QSI) compound produced by V. alginolyticus M3-10. N-Acetyltyramine is capable of inhibiting the QS of C. violaceum ATCC 12472. N-acetyltyramine reverses resistance in Doxorubicin-resistant leukemia P388 cells[1][2]. Related Catalog Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial In Vitro N-Acetyltyramine enhances cytotoxicity of doxorubicin in resistant P388 murine leukemia cells with an IC50 value of 0.13 μg/ml compared with an IC50 value of 0.48 µg/ml for doxorubicin alone[2]. References [1]. Reina JC, et al. A Quorum-Sensing Inhibitor Strain of Vibrio alginolyticus Blocks Qs-Controlled Phenotypes in Chromobacterium violaceum and Pseudomonas aeruginosa. Mar Drugs. 2019;17(9):494. Published 2019 Aug 24. [2]. Kunimoto S, et al. Reversal of resistance by N-acetyltyramine or N-acetyl-2-phenylethylamine in doxorubicin-resistant leukemia P388 cells. J Antibiot (Tokyo). 1987;40(11):1651-1652. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 424.1±28.0 °C at 760 mmHg Melting Point 134°C Molecular Formula C10H13NO2 Molecular Weight 179.216 Flash Point 210.3±24.0 °C Exact Mass 179.094635 PSA 49.33000 LogP 0.39 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.546 InChIKey ATDWJOOPFDQZNK-UHFFFAOYSA-N SMILES CC(=O)NCCc1ccc(O)cc1 Storage condition 2-8°C |
| Use of | Properties Articles10 Name N-[2-(4-hydroxyphenyl)ethyl]acetamide Synonym More Synonyms N-Acetyltyramine Biological Activity Related Catalog Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial References [1]. Reina JC, et al. A Quorum-Sensing Inhibitor Strain of Vibrio alginolyticus Blocks Qs-Controlled Phenotypes in Chromobacterium violaceum and Pseudomonas aeruginosa. Mar Drugs. 2019;17(9):494. Published 2019 Aug 24. Chemical & Physical Properties Molecular Formula C10H13NO2 Exact Mass 179.094635 PSA 49.33000 Index of Refraction 1.546 InChIKey ATDWJOOPFDQZNK-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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