| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1190-53-0 |
| Catalog No. | 2A-9026405 |
| Chinese Name | 丁双胍盐酸盐 |
| Synonyms | EINECS 214-723-6; butyl-biguanide hydrochloride |
| Molecular Formula | C6H16N5Cl1 |
| Molecular Weight | 193.68 |
| Purity | 98.00 |
| Boiling Point | 322.7ºC at 760 mmHg |
| Melting Point | 174-177ºC |
| Storage Condition | 1. The warehouse is ventilated and dried at low te |
| Application | Buformin hydrochloride (1-Butylbiguanide hydrochloride) is a potent, orally active antidiabetic agent and an AMPK activator. Buformin decreases hepatic gluconeogenesis and decreases glycemia. Buformin |
| HTC | 2925290090 |
| PubChem ID | 555148 |
| MDL Number | MFCD00045591 |
| SMILES | CCCCN=C(N)N=C(N)N.Cl |
| InChI | InChI=1S/C6H15N5.ClH/c1-2-3-4-10-6(9)11-5(7)8;/h2-4H2,1H3,(H6,7,8,9,10,11);1H |
| InChI Key | KKLWSPPIRBIEOV-UHFFFAOYSA-N |
| MSDS | msds/26405_1_1190_53_0.pdf |
| Use of | Buformin hydrochloride (1-Butylbiguanide hydrochloride) is a potent and orally active biguanide antidiabetic agent, an AMPK activator. Buformin hydrochloride decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin hydrochloride also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al)[1]. Properties Name Buformin Hydrochloride Synonym More Synonyms Buformin hydrochloride Biological Activity Description Buformin hydrochloride (1-Butylbiguanide hydrochloride) is a potent and orally active biguanide antidiabetic agent, an AMPK activator. Buformin hydrochloride decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin hydrochloride also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al)[1]. Related Catalog Signaling Pathways >> Epigenetics >> AMPK Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> AMPK References [1]. Amanda B Parris, et al. Buformin hydrochloride Inhibits the Stemness of erbB-2-overexpressing Breast Cancer Cells and Premalignant Mammary Tissues of MMTV-erbB-2 Transgenic Mice. J Exp Clin Cancer Res [2]. Jing Li, et al. Buformin hydrochloride Suppresses Proliferation and Invasion via AMPK/S6 Pathway in Cervical Cancer and Synergizes With Paclitaxel. Cancer Biol Ther. 2018 Jun 3;19(6):507-517. Chemical & Physical Properties Exact Mass 193.10900 PSA 97.78000 LogP 2.27750 InChIKey KKLWSPPIRBIEOV-UHFFFAOYSA-N SMILES CCCCN=C(N)N=C(N)N.Cl Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Biguanide, 1-butyl-, monohydrochloride CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : WISWESSER LINE NOTATION : MUYZMYUM&M4 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Human Embryo DOSE/DURATION : REFERENCE : SNSHBT Senshokutai. Chromosome. (Sensyokutai Gakkai, Kaokusai Kirisutokyo Daigaku, Mitaka, Tokyo-to, Japan) No.1- 1946- Adopted new numbering in 1976. Volume(issue)/page/year: (20),574,1980 Safety Information GHS05, GHS07 Signal Word Danger Hazard Statements H302-H315-H318-H335 Precautionary Statements P280-P301 + P312 + P330-P305 + P351 + P338 + P310 Hazard Codes Xi Risk Phrases 22-43-36 RIDADR NONH for all modes of transport HS Code 2925290090 |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Product name: Summary 2925290090 other imines and their derivatives; salts thereof. Supervision conditions:None. VAT: 17.0%. Tax rebate rate:9.0%. MFN tariff: 6.5%. General tariff:30.0% |
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