CAS Number1070-11-7
Synonyms2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) dihydrochloride; (S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediamine Dihydrochloride; (2S,2'S)-2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) dihydrochloride; (S,S)-2,2'-(1,2-Ethanediyldiimino)bis-1-butanol Dihydrochloride; (2S,2'S)-2,2'-(Ethane-1,2-diyldiimino)dibutan-1-ol dihydrochloride; Ethambutol hydrochloride; Ethambutol dihydrochloride; (2S,2'S)-2,2'-(1,2-Ethanediyldiimino)di(1-butanol) dihydrochloride; 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (2S,2'S)-, hydrochloride (1:2); MFCD00216025; EINECS 213-970-7; 2,2'-[1,2-Ethanediyldi(imino)]di(1-butanol) dihydrochloride
Molecular FormulaC10H26Cl2N2O2
Molecular Weight277.23
Purity98.00%
Boiling Point345.3ºC at 760 mmHg
Melting Point198-200°C
Appearancepowder
EINECS213-970-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1070-11-7 |
| Catalog No. | 2A-9026009 |
| Chinese Name | 盐酸乙胺丁醇 |
| Synonyms | 2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) dihydrochloride; (S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediamine Dihydrochloride; (2S,2'S)-2,2'-(Ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) dihydrochloride; (S,S)-2,2'-(1,2-Ethanediyldiimino)bis-1-butanol Dihydrochloride; (2S,2'S)-2,2'-(Ethane-1,2-diyldiimino)dibutan-1-ol dihydrochloride; Ethambutol hydrochloride; Ethambutol dihydrochloride; (2S,2'S)-2,2'-(1,2-Ethanediyldiimino)di(1-butanol) dihydrochloride; 1-Butanol, 2,2'-(1,2-ethanediyldiimino)bis-, (2S,2'S)-, hydrochloride (1:2); MFCD00216025; EINECS 213-970-7; 2,2'-[1,2-Ethanediyldi(imino)]di(1-butanol) dihydrochloride |
| Molecular Formula | C10H26Cl2N2O2 |
| Molecular Weight | 277.23 |
| Purity | 98.00 |
| Boiling Point | 345.3ºC at 760 mmHg |
| Melting Point | 198-200°C |
| Appearance | powder |
| Water Solubility | Water solubility: completely soluble; slightly sol |
| Storage Condition | Keep container sealed and store in a cool, dry pla |
| Application | Ethambutol dihydrochloride is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity. |
| EINECS | 213-970-7 |
| HTC | 2922191000 |
| PubChem ID | 24894566 |
| MDL Number | MFCD21364080 |
| SMILES | CC[C@@H](CO)NCCN[C@H](CO)CC.Cl.Cl |
| InChI | 1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1 |
| InChI Key | AUAHHJJRFHRVPV-BZDVOYDHSA-N |
| NACRES Code | NA.85 |
| UNSPSC | 51281511 |
| Hazard Symbols | transportation |
| MSDS | msds/26009_1_1070_11_7.pdf |
| Bioactivity | Ethambutol Dihydrochloride is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.Target: AntibacterialEthambutol directly affects two polymers, arabinogalactan (AG) and lipoarabinomannan (LAM) in Mycobacterium smegmatis. In M. smegmatis, Ethambutol inhibits synthesis of arabinan completely and inhibits AG synthesis most likely as a consequence of this; more than 50% of the cell arabinan is released from the bacteria following Ethambutol treatment, whereas no galactan is released. Ethambutol main targets against embB gene product in M. avium. Ethambutol induces 60% changes in the embB gene in M. tuberculosis resistant mutants [1]. Ethambutol is effective against actively growing microorganisms of the genus Mycobacterium, including M. tuberculosis. Nearly all strains of M. tuberculosis and M. kansasii as well as a number of strains of the M. aviumcomplex (MAC) are sensitive to Ethambutol. [1] Ethambutol is potency against M. tuberculosis (H37Rv) with MIC of 0.5 μg/mL in vitro [2]. Ethambutol is efficient on treatment of mycobacterial-infected macrophages. When M. tuberculosis infected macrophages are treated with 6 μg/mL Ethambutol, the log CFUs following treatment for 3 days is 4.17, while value in control group is 4.8. The MICs for M. avium (MTCC 1723) and M. smegmatis (MTCC 6) are 15 μg/mL and 0.18 μg/mL, respectively. Ethambutol is efficient in animal model. 100 mg/kg Ethambutol given orally 15 days post i.v. infection 1 ×/week for 5 weeks, induces a lower log CFU compared with untreatment (4.59 vs 5.07) [3]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Ethambutol. Tuberculosis (Edinb), 2008. 88(2): p. 102-5. [2]. Rastogi, N., V. Labrousse, and K.S. Goh, In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain [3]. Kaur, D. and G.K. Khuller, In vitro, ex-vivo and in vivo activities of ethambutol and sparfloxacin alone and in combination against mycobacteria. Int J Antimicrob Agents, 2001. 17(1): p. 51-5. Chemical & Physical Properties Boiling Point 345.3ºC at 760 mmHg Melting Point 198-200°C Molecular Formula C10H26Cl2N2O2 Molecular Weight 277.232 Flash Point 113.7ºC Exact Mass 276.137146 PSA 64.52000 LogP 2.09320 Vapour Pressure 3.35E-07mmHg at 25°C InChIKey AUAHHJJRFHRVPV-BZDVOYDHSA-N SMILES CCC(CO)NCCNC(CC)CO.Cl.Cl Storage condition Refrigerator |
| Use of | Properties Articles25 Name ethambutol dihydrochloride Synonym More Synonyms Ethambutol dihydrochloride Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Ethambutol. Tuberculosis (Edinb), 2008. 88(2): p. 102-5. [2]. Rastogi, N., V. Labrousse, and K.S. Goh, In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain [3]. Kaur, D. and G.K. Khuller, In vitro, ex-vivo and in vivo activities of ethambutol and sparfloxacin alone and in combination against mycobacteria. Int J Antimicrob Agents, 2001. 17(1): p. 51-5. Chemical & Physical Properties Exact Mass 276.137146 PSA 64.52000 LogP 2.09320 InChIKey AUAHHJJRFHRVPV-BZDVOYDHSA-N SMILES CCC(CO)NCCNC(CC)CO.Cl.Cl Storage condition Refrigerator |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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