CAS Number1069-66-5
Synonyms2-Propylpentanoic acid,sodium salt; EINECS 213-961-8; Sodium 2-propylvalerate; Depakin; Ergenyl; Epilim; 2-Propylpentanoic acid; MFCD00078604; 2-Propylvaleric acid sodium salt; Sodium Valproate; Depakine; 2-Propylpentanoic Acid Sodium Salt; Depakene; Pentanoic acid, 2-propyl-, sodium salt (1:1); sodium,2-propylpentanoate; Sodium 2-propylpentanoate; Valproic acid, sodium salt; DEPACON; Valproic acid sodium salt; 2-Propylpentanoic acid sodium; Valproate Sodium; UNII:5VOM6GYJ0D; Valproic acid (sodium salt)
Molecular FormulaC8H15NaO2
Molecular Weight166.19
Purity98.00%
Density1.0803 g/cm3
Boiling Point220ºC at 760 mmHg
Melting Point300 °C
Appearancewhite powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1069-66-5 |
| Catalog No. | 2A-9026006 |
| Chinese Name | 丙戊酸钠 |
| Synonyms | 2-Propylpentanoic acid,sodium salt; EINECS 213-961-8; Sodium 2-propylvalerate; Depakin; Ergenyl; Epilim; 2-Propylpentanoic acid; MFCD00078604; 2-Propylvaleric acid sodium salt; Sodium Valproate; Depakine; 2-Propylpentanoic Acid Sodium Salt; Depakene; Pentanoic acid, 2-propyl-, sodium salt (1:1); sodium,2-propylpentanoate; Sodium 2-propylpentanoate; Valproic acid, sodium salt; DEPACON; Valproic acid sodium salt; 2-Propylpentanoic acid sodium; Valproate Sodium; UNII:5VOM6GYJ0D; Valproic acid (sodium salt) |
| Molecular Formula | C8H15NaO2 |
| Molecular Weight | 166.19 |
| Purity | 98.00 |
| Density | 1.0803 g/cm3 |
| Boiling Point | 220ºC at 760 mmHg |
| Melting Point | 300 °C |
| Appearance | white powder |
| Water Solubility | soluble |
| Storage Condition | Keep container sealed and store in a cool, dry pla |
| Packaging | III |
| Application | Valproic acid sodium salt is an anticonvulsant used to treat epilepsy, bipolar disorder and migraines. Valproic acid inhibits histone deacetylase 1 (HDAC1) with an IC50 of 0.4 mM. |
| HTC | 2915900090 |
| PubChem ID | 3140830 |
| SMILES | CCCC(CCC)C(=O)[O-].[Na+] |
| InChI | InChI=1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1 |
| InChI Key | AEQFSUDEHCCHBT-UHFFFAOYSA-M |
| Hazard Symbols | 6.1(b) |
| Bioactivity | Valproic acid sodium salt is an anticonvulsants used to treat epilepsy, bipolar disorder and migraines. Valproic acid inhibits histone deacetylase 1 (HDAC1) with an IC50 of 0.4 mM. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC Signaling Pathways >> Autophagy >> Mitophagy Natural Products >> Acids and Aldehydes Research Areas >> Cancer Target HDAC1:400 μM (IC50) HDAC:0.5-2 mM (IC50) HDAC2 Autophagy Mitophagy In Vitro Valproic acid inhibits the growth dose- and time-dependently with an IC50 of appr 10 and 4 mM at 24 and 72 h, respectively. Valproic acid significantly attenuates the activities of total, cytosol and nuclear HDACs. Valproic acid increases the form of acetylated histone 3 in HeLa cells. Valproic acid (1-3 mM) induces a G1 phase arrest, while 10 mM Valproic acid significantly induces a G2/M phase arrest of cell cycle in HeLa cells. In addition, Valproic acid increases the percentage of sub-G1 cells in HeLa cells in a dose-dependent manner at 24 h[1]. Valproic acid inhibits the mRNA and protein expression of VEGF, VEGFR2 and bFGF. Valproic acid inhibits the protein expression of HDAC1, increases histone H3 acetylation, and enhances the accumulation of hyperacetylated histone H3 on VEGF promoters[2]. Valproic acid treatment results in increased levels of phosphorylated AMPK/ACC in primary mouse hepatocytes. Phosphorylation of ACC following Valproic acid treatment is AMPK-dependent. Valproic acid inhibits the deacetylase activity of both mouse liver nuclear extracts and human recombinant HDAC1 while of the metabolites of Valproic acid, only 2-ene-Valproic acid and 4-ene-Valproic acid diminish deacetylase activity[4]. In Vivo Valproic acid (500 mg/kg, i.p.) inhibits the tumor growth and angiogenesisin the mice transplanted with Kasumi-1 cells. The IR rate in the Valproic acid group is 57.25% at the end of the experiment[2]. Valproic acid (350 mg/kg, i.p.) demonstrates more social investigation and play fighting than control animals[3]. Kinase Assay The activity of caspase-3, -8 and -9 is assessed using the caspase-3, -8 and -9 colorimetric assay kits, respectively. In brief, 1×106 cells in a 60-mm culture dish are incubated with 10 mM Valproic acid for 24 h. The cells are then washed in PBS and suspended in 5 volumes of lysis buffer provided with the kit. Protein concentrations are determined using the Bradford method. Supernatants containing 50 μg total protein are used to determine caspase-3, -8 and -9 activities. The supernatants are added to each well in 96-well microtiter plates with DEVD-pNA, IETD-pNA or LEHD-pNA as caspase-3, -8 and -9 substrates and the plates are incubated at 37°C for 1 h. The optical density of each well is measured at 405 nm using a microplate reader. The activity of caspase-3, -8 and -9 is expressed in arbitrary absorbance units. Cell Assay In brief, 5×105 cells are seeded in 96-well microtiter plates for MTT assays. After exposure to the designated doses of Valproic acid for the indicated times, MTT solution [20 mL: 2 mg/mL in phosphate-buffered saline (PBS)] is added to each well of the 96-well plates. The plates are additionally incubated for 3 h at 37°C. Medium is withdrawn from the plates by pipetting and 200 mL DMSO is added to each well to solubilize the formazan crystals. The optical density is measured at 570 nm using a microplate reader. Animal Admin Splenectomies are performed on the BALB/c nude mice. One week after the splenectomies, the mice receiv whole body irradiation with 137Cs at a dose of 4 Gy. At 48-72 h post-irradiation, the mice are subcutaneously implanted with Kasumi-1 cells (2×107 cells/mouse with 0.15-0.2 mL) in the right axillary region. The mice are randomLy assigned to two groups, the Valproic acid (n=6) and control (n=6) groups. When the tumors are appr 200 mm3 in size at appr 10 days post-implantation, 0.2 mL Valproic acid (500 mg/kg body weight) or 0.2 mL saline is injected intraperitoneally every day. Valproic acid is dissolved in saline at a concentration of 25 mg/mL. The longest diameter (a) and the shortest diameter (b) of the tumor are measured every three days, and the tumor volume (TV) is calculated according to the following formula: TV=1/2×a×b2. Following two weeks of injections, the mice are sacrificed by cervical dislocation and the tumor masses are removed for the following experiments. References [1]. Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30(6):2999-3005. [2]. Zhang ZH, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28. [3]. Cohen OS, et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31(8):740-50. [4]. Avery LB, et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85(1):1-10. [5]. Valproic acid, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28;276(39):36734-41. Chemical & Physical Properties Density 1.0803 g/cm3 Boiling Point 220ºC at 760 mmHg Melting Point 300 °C Molecular Formula C8H15NaO2 Molecular Weight 166.193 Flash Point STABILITY Exact Mass 166.096970 PSA 40.13000 LogP 0.95270 Vapour Pressure 0.0435mmHg at 25°C InChIKey AEQFSUDEHCCHBT-UHFFFAOYSA-M SMILES CCCC(CCC)C(=O)[O-].[Na+] Storage condition Desiccate at RT Water Solubility soluble |
| Use of | Properties Articles70 Name sodium valproate Synonym More Synonyms Sodium 2-propylpentanoate Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC Signaling Pathways >> Autophagy >> Mitophagy Natural Products >> Acids and Aldehydes Research Areas >> Cancer HDAC1:400 μM (IC50) References [1]. Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30(6):2999-3005. [3]. Cohen OS, et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31(8):740-50. [4]. Avery LB, et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85(1):1-10. [5]. Valproic acid, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28;276(39):36734-41. Chemical & Physical Properties Molecular Formula C8H15NaO2 Exact Mass 166.096970 PSA 40.13000 LogP 0.95270 InChIKey AEQFSUDEHCCHBT-UHFFFAOYSA-M SMILES CCCC(CCC)C(=O)[O-].[Na+] Storage condition Desiccate at RT Water Solubility soluble |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Imported food hygiene supervision and inspection S. Export food hygiene supervision and inspection M. Imported commodity inspection N. Exported commodity inspection |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip. |
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