CAS Number980-71-2
Synonyms(±)-2-[p-Bromo-a-(2-dimethylaminoethyl)benzyl]pyridine Maleate; D-Brompheniramine; dl-Bromopheniramine Maleate; Brompheniramine Maleate; (±)-Brompheniramine maleate; 3-(4-Bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine (2Z)-2-butenedioate (1:1); Brompheniramine d; 3-(4-Bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine (2Z)-but-2-enedioate (1:1); (±)-1-(4-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane; 2-pyridinepropanamine, g-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1); Ilvin Maleate; (RS)-brompheniramine; MFCD00057367; EINECS 213-562-9; PARABROMODYLAMINE MALEATE; brompheniramine hydrogen maleate; 2-Pyridinepropanamine, γ-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1); acide (2Z)-but-2-ènedioïque - 3-(4-bromophényl)-N,N-diméthyl-3-pyridin-2-ylpropan
Molecular FormulaC20H23BrN2O4
Molecular Weight435.31
Purity98.00%
Boiling Point403ºC at 760 mmHg
Melting Point134-135ºC
Appearancepowder
EINECS213-562-9
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 980-71-2 |
| Catalog No. | 2A-9025815 |
| Chinese Name | 马来酸溴苯那敏 |
| Synonyms | (±)-2-[p-Bromo-a-(2-dimethylaminoethyl)benzyl]pyridine Maleate; D-Brompheniramine; dl-Bromopheniramine Maleate; Brompheniramine Maleate; (±)-Brompheniramine maleate; 3-(4-Bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine (2Z)-2-butenedioate (1:1); Brompheniramine d; 3-(4-Bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine (2Z)-but-2-enedioate (1:1); (±)-1-(4-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane; 2-pyridinepropanamine, g-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1); Ilvin Maleate; (RS)-brompheniramine; MFCD00057367; EINECS 213-562-9; PARABROMODYLAMINE MALEATE; brompheniramine hydrogen maleate; 2-Pyridinepropanamine, γ-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1); acide (2Z)-but-2-ènedioïque - 3-(4-bromophényl)-N,N-diméthyl-3-pyridin-2-ylpropan |
| Molecular Formula | C20H23BrN2O4 |
| Molecular Weight | 435.31 |
| Purity | 98.00 |
| Boiling Point | 403ºC at 760 mmHg |
| Melting Point | 134-135ºC |
| Appearance | powder |
| Water Solubility | Water solubility: soluble |
| Storage Condition | Keep container sealed and store in a cool, dry pla |
| Packaging | III |
| Application | Bromfeniramine maleate is a histamine H1 receptor antagonist. |
| EINECS | 213-562-9 |
| HTC | 2934999090 |
| MDL Number | MFCD00057367 |
| SMILES | OC(=O)\C=C/C(O)=O.CN(C)CCC(c1ccc(Br)cc1)c2ccccn2 |
| InChI | 1S/C16H19BrN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1- |
| InChI Key | SRGKFVAASLQVBO-BTJKTKAUSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/25815_1_980_71_2.pdf |
| Bioactivity | Brompheniramine maleate is a histamine H1 receptors antagonist.Target: Histamine H1 ReceptorBrompheniramine maleate, is an antihistamine drug of the propylamine (alkylamine) class. It is readily available over the counter and is indicated for the treatment of the symptoms of the common cold and allergic rhinitis. It is a first-generation antihistamine. Brompheniramine has antidepressant properties, inhibiting reuptake of the neurotransmitter serotonin. Based on this knowledge, Arvid Carlsson and his colleagues, working at the Swedish company Astra AB, were able to derive the first marketed selective serotonin reuptake inhibitor, zimelidine, from brompheniramine. Brompheniramine had a long half-life and large volume of distribution in normal adults. It also had a prolonged antihistaminic effect in the skin as evidenced by suppression of the wheal and flare response to histamine and by suppression of pruritus [1, 2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology References [1]. http://en.wikipedia.org/wiki/Brompheniramine [2]. Simons, F.E., E.M. Frith, and K.J. Simons, The pharmacokinetics and antihistaminic effects of brompheniramine. J Allergy Clin Immunol, 1982. 70(6): p. 458-64. Chemical & Physical Properties Boiling Point 403ºC at 760 mmHg Melting Point 134-135ºC Molecular Formula C20H23BrN2O4 Molecular Weight 435.312 Exact Mass 434.084106 PSA 90.73000 LogP 3.63950 InChIKey SRGKFVAASLQVBO-BTJKTKAUSA-N SMILES CN(C)CCC(c1ccc(Br)cc1)c1ccccn1.O=C(O)C=CC(=O)O |
| Use of | Brompheniramine maleate is a histamine H1 receptors antagonist.Target: Histamine H1 ReceptorBrompheniramine maleate, is an antihistamine drug of the propylamine (alkylamine) class. It is readily available over the counter and is indicated for the treatment of the symptoms of the common cold and allergic rhinitis. It is a first-generation antihistamine. Brompheniramine has antidepressant properties, inhibiting reuptake of the neurotransmitter serotonin. Based on this knowledge, Arvid Carlsson and his colleagues, working at the Swedish company Astra AB, were able to derive the first marketed selective serotonin reuptake inhibitor, zimelidine, from brompheniramine. Brompheniramine had a long half-life and large volume of distribution in normal adults. It also had a prolonged antihistaminic effect in the skin as evidenced by suppression of the wheal and flare response to histamine and by suppression of pruritus [1, 2]. Properties Articles26 Name brompheniramine maleate Synonym More Synonyms Brompheniramine Maleate Biological Activity Description Brompheniramine maleate is a histamine H1 receptors antagonist.Target: Histamine H1 ReceptorBrompheniramine maleate, is an antihistamine drug of the propylamine (alkylamine) class. It is readily available over the counter and is indicated for the treatment of the symptoms of the common cold and allergic rhinitis. It is a first-generation antihistamine. Brompheniramine has antidepressant properties, inhibiting reuptake of the neurotransmitter serotonin. Based on this knowledge, Arvid Carlsson and his colleagues, working at the Swedish company Astra AB, were able to derive the first marketed selective serotonin reuptake inhibitor, zimelidine, from brompheniramine. Brompheniramine had a long half-life and large volume of distribution in normal adults. It also had a prolonged antihistaminic effect in the skin as evidenced by suppression of the wheal and flare response to histamine and by suppression of pruritus [1, 2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology References [1]. http://en.wikipedia.org/wiki/Brompheniramine [2]. Simons, F.E., E.M. Frith, and K.J. Simons, The pharmacokinetics and antihistaminic effects of brompheniramine. J Allergy Clin Immunol, 1982. 70(6): p. 458-64. Chemical & Physical Properties Molecular Formula C20H23BrN2O4 Exact Mass 434.084106 PSA 90.73000 LogP 3.63950 InChIKey SRGKFVAASLQVBO-BTJKTKAUSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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