CAS Number969-33-5
Synonyms4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride; Piperidine, 4- (5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride; periactinolhydrochloride; cyproheptadienehydrochloride; 4-(5H-Dibenzo[a,d][7]annulen-5-yliden)-1-methylpiperidinhydrochlorid; 4-(5H-dibenzo[a,d][7]annulén-5-ylidène)-1-méthylpipéridine chlorhydrate; piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride; 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine Hydrochloride; CYPROHEPTADINE HCL BP; peritol; ANAREXOL; Cyproheptadin; Piperidine,4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride (1:1); periactinhydrochloride; MFCD00012538; cyproheptadine hydrochloride; CYPROHEPTADINE HCL; EINECS 213-535-1; Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-yl
Molecular FormulaC21H22N1Cl1
Molecular Weight323.87
Purity98.00%
Boiling Point440.1ºC at 760mmHg
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 969-33-5 |
| Catalog No. | 2A-9025800 |
| Chinese Name | 盐酸赛庚啶 |
| Synonyms | 4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride; Piperidine, 4- (5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride; periactinolhydrochloride; cyproheptadienehydrochloride; 4-(5H-Dibenzo[a,d][7]annulen-5-yliden)-1-methylpiperidinhydrochlorid; 4-(5H-dibenzo[a,d][7]annulén-5-ylidène)-1-méthylpipéridine chlorhydrate; piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride; 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine Hydrochloride; CYPROHEPTADINE HCL BP; peritol; ANAREXOL; Cyproheptadin; Piperidine,4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride (1:1); periactinhydrochloride; MFCD00012538; cyproheptadine hydrochloride; CYPROHEPTADINE HCL; EINECS 213-535-1; Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-yl |
| Molecular Formula | C21H22N1Cl1 |
| Molecular Weight | 323.87 |
| Purity | 98.00 |
| Boiling Point | 440.1ºC at 760mmHg |
| Appearance | powder |
| Water Solubility | ethanol: soluble |
| Storage Condition | Keep container sealed and store in a cool, dry pla |
| Packaging | III |
| Application | Cyproheptadine is a 5-HT2 receptor antagonist with an IC50 of 0.6 nM. |
| HTC | 2933399090 |
| MDL Number | MFCD00012538 |
| SMILES | CN1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1.Cl |
| InChI | InChI=1S/C21H21N.ClH/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;/h2-11H,12-15H2,1H3;1H |
| InChI Key | ZPMVNZLARAEGHB-UHFFFAOYSA-N |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/25800_1_969_33_5.pdf |
| Use of | Cyproheptadine is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM. Target: 5-HT2 ReceptorCyproheptadine is a serotonin antagonist and a histamine H2 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. Inhibitory effects of cyclobenzaprine, amitriptyline, and cyproheptadine on mono- and polysynaptic reflex potentials are due to the inhibition of descending serotonergic systems through 5-HT(2) receptors in the spinal cord [1, 2]. Properties Name cyproheptadine hydrochloride (anhydrous) Synonym More Synonyms cyproheptadine hydrochloride Biological Activity Description Cyproheptadine is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM. Target: 5-HT2 ReceptorCyproheptadine is a serotonin antagonist and a histamine H2 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. Inhibitory effects of cyclobenzaprine, amitriptyline, and cyproheptadine on mono- and polysynaptic reflex potentials are due to the inhibition of descending serotonergic systems through 5-HT(2) receptors in the spinal cord [1, 2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease References [1]. Honda, M., T. Nishida, and H. Ono, Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. Eur J Pharmacol, 2003. 458(1-2): p. 91-9. [2]. Calka, O., et al., Effect of cyproheptadine on serum leptin levels. Adv Ther, 2005. 22(5): p. 424-8. Chemical & Physical Properties Exact Mass 323.144073 PSA 3.24000 LogP 5.43780 InChIKey ZPMVNZLARAEGHB-UHFFFAOYSA-N Storage condition Store at RT Water Solubility ethanol: soluble Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Piperidine, 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methyl-, hydrochloride CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C21-H21-N.Cl-H MOLECULAR WEIGHT : WISWESSER LINE NOTATION : L C676 BYJ BU- DT6N DYTJ A1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Human - woman DOSE/DURATION : TOXIC EFFECTS : Gastrointestinal - other changes Liver - jaundice, cholestatic Liver - liver function tests impaired TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 52400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 55300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 5-16 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - homeostasis TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 13-20 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - endocrine system MUTATION DATA TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 2200 umol/L/24H (Continuous) REFERENCE : ZEKIA5 Zeitschrift fuer Kinderheilkunde. (Berlin, Ger.) V.1-120, 1910-75. For publisher information, see EJPEDT. Volume(issue)/page/year: 118,219,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3187 No. of Facilities: 79 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 2047 (estimated) No. of Female Employees: 947 (estimated) Safety Information Hazard Codes Xn: Harmful; Safety Phrases 26-36 RIDADR UN 2811 WGK Germany 3 RTECS TM7050000 Packaging Group III Hazard Class 6.1(b) HS Code 2933399090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| meso-1,2-Diphenylethylenediamine | 951-87-1 | 2A-9025774 |
| Ethyl 4-nitrocinnamate | 953-26-4 | 2A-9025775 |
| Diphenamid | 957-51-7 | 2A-9025779 |
| Endosulfan I | 959-98-8 | 2A-9025787 |
| Androst-2-en-17-one | 963-75-7 | 2A-9025794 |
| Difenidol | 972-02-1 | 2A-9025803 |
| 16,17-Epoxypregnenolone | 974-23-2 | 2A-0202171 |
| Phenylfluorone | 975-17-7 | 2A-9025805 |
| 4-Butyl-3-hydroxy-1-(4-hydroxyphenyl)-2-phenyl-3-pyrazolin-5-one | 975-18-8 | 2A-9025806 |
| Diethyl 3,5-di-tert-butyl-4-hydroxybenzyl phosphate | 976-56-7 | 2A-9025808 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS