CAS Number929-59-9
Synonyms2,2′-(ethylenedioxy)bis(ethylamine); 1,8-diaminotriethyleneglycol; MFCD00040474; 2,2'-[1,2-Ethanediylbis(oxy)]diethanamine; 2,2'-[ethane-1,2-diylbis(oxy)]diethanamine; 1,2-Bis(2-aminoethoxy)ethane; UNII-R41ZT4UF34; Jeffamine® EDR-176; EDR-148; TRIETHYLENEGLYCOLDIAMINE; 1,8-Diamino-3,6-dioxaoctane; DA-10; Jeffamine(R) EDR-176; 2,2'-(Ethylenedioxy)bis(ethylamine); 1,8-diamino-3,6-dioxa-octane; 3,6-dioxaoctamethylenediamine; 3,6-dioxa-1,8-octanediamine; EINECS 213-203-6; Jeffamine EDR-148
Molecular FormulaNH2CH2CH2OCH2CH2OCH2CH2NH2
Molecular Weight148.20
Purity98%
Density1.0±0.1 g/cm3
Boiling Point105-109 °C/6 mmHg (lit.)
Appearanceliquid
EINECS213-203-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 929-59-9 |
| Catalog No. | 2A-9025643 |
| Chinese Name | 1,8-二氨基-3,6-二氧杂辛烷 |
| Synonyms | 2,2′-(ethylenedioxy)bis(ethylamine); 1,8-diaminotriethyleneglycol; MFCD00040474; 2,2'-[1,2-Ethanediylbis(oxy)]diethanamine; 2,2'-[ethane-1,2-diylbis(oxy)]diethanamine; 1,2-Bis(2-aminoethoxy)ethane; UNII-R41ZT4UF34; Jeffamine® EDR-176; EDR-148; TRIETHYLENEGLYCOLDIAMINE; 1,8-Diamino-3,6-dioxaoctane; DA-10; Jeffamine(R) EDR-176; 2,2'-(Ethylenedioxy)bis(ethylamine); 1,8-diamino-3,6-dioxa-octane; 3,6-dioxaoctamethylenediamine; 3,6-dioxa-1,8-octanediamine; EINECS 213-203-6; Jeffamine EDR-148 |
| Molecular Formula | NH2CH2CH2OCH2CH2OCH2CH2NH2 |
| Molecular Weight | 148.20 |
| Purity | 98 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 105-109 °C/6 mmHg (lit.) |
| Appearance | liquid |
| Storage Condition | Keep container sealed and store in a cool, dry pla |
| Packaging | III |
| Application | PROTAC Linker 19 is a PROTAC link bridge, belonging to the alkyl/ether class. PROTAC Linker 19 can be used to synthesize a range of PROTAC molecules. PROTAC molecules contain two different ligands con |
| EINECS | 213-203-6 |
| HTC | 2922199090 |
| PubChem ID | 24864032 |
| MDL Number | MFCD00040474 |
| SMILES | NCCOCCOCCN |
| InChI | 1S/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2 |
| InChI Key | IWBOPFCKHIJFMS-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1739187 |
| NACRES Code | NA.23 |
| UNSPSC | 12162002 |
| Hazard Symbols | 8 |
| MSDS | msds/25643_1_929_59_9.pdf |
| Bioactivity | PROTAC Linker 19 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 19 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target Alkyl/ether References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 241.0±20.0 °C at 760 mmHg Molecular Formula C6H16N2O2 Molecular Weight 148.203 Flash Point 104.3±15.5 °C Exact Mass 148.121185 PSA 70.50000 LogP -1.59 Vapour Pressure 0.0±0.5 mmHg at 25°C Index of Refraction 1.460 InChIKey IWBOPFCKHIJFMS-UHFFFAOYSA-N SMILES NCCOCCOCCN |
| Use of | Properties Articles10 Name 1,8-Diamino-3,6-dioxaoctane Synonym More Synonyms ethylene glycol bis(2-aminoethyl) ether Biological Activity Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl/ether References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. Chemical & Physical Properties Molecular Formula C6H16N2O2 Exact Mass 148.121185 PSA 70.50000 LogP -1.59 Index of Refraction 1.460 InChIKey IWBOPFCKHIJFMS-UHFFFAOYSA-N SMILES NCCOCCOCCN |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 95.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Dangerous Regulations for land transport: 2735 International Dangerous Regulations for sea transport: 2735 International Dangerous Regulations for air transport: 2735 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: POLYAMINES, LIQUID, CORROSIVE, N.O.S. (3,6-Dioxaoctamethylenediamine) IMDG: POLYAMINES, LIQUID, CORROSIVE, N.O.S. (3,6-Dioxaoctamethylenediamine) International air transport hazard regulations: Polyamines, liquid, corrosive, n.o.s. (3,6-Dioxaoctamethylenediamine) 14.3 Transport hazard categories European Dangerous Regulations for land transport: 8 International Dangerous Regulations for sea transport: 8 International Dangerous Regulations for air transport: 8 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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