CAS Number816-94-4
SynonymsEINECS 212-440-2; MFCD00036905; (2R)-2,3-Bis(stearoyloxy)propyl 2-(trimethylammonio)ethyl phosphate; 1,2-Distearoyl-sn-glycero-3-phosphocholine; (2R)-2,3-bis(octadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate; L-α-PHOSPHATIDYLCHOLINE, DISTEAROYL
Molecular FormulaC44H88NO8P
Molecular Weight790.15
Purity>99 (TLC)%
Melting Point236 °C
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 816-94-4 |
| Catalog No. | 2A-9025296 |
| Chinese Name | 二硬脂酰磷脂酰胆碱 |
| Synonyms | EINECS 212-440-2; MFCD00036905; (2R)-2,3-Bis(stearoyloxy)propyl 2-(trimethylammonio)ethyl phosphate; 1,2-Distearoyl-sn-glycero-3-phosphocholine; (2R)-2,3-bis(octadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate; L-α-PHOSPHATIDYLCHOLINE, DISTEAROYL |
| Molecular Formula | C44H88NO8P |
| Molecular Weight | 790.15 |
| Purity | >99 (TLC) |
| Melting Point | 236 °C |
| Appearance | powder |
| Water Solubility | Slightly soluble: chloroform |
| Storage Condition | Sealed storage at -20°C |
| Application | 1,2-Distearoyl-sn-glycerol-3-phosphorylcholine (1,2-distearoyl-sn-glycerol-3-PC; DSPC) is a cylindrical liposome. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes and is t |
| MDL Number | MFCD00036905 |
| SMILES | [O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O |
| InChI | 1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1 |
| InChI Key | NRJAVPSFFCBXDT-HUESYALOSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 51191904 |
| Hazard Symbols | transportation |
| MSDS | msds/25296_1_816_94_4.pdf |
| Bioactivity | 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others In Vitro In empty lipid nanoparticle (LNP) systems that do not contain siRNA, DSPC-cholesterol resides in outer layers, whereas in loaded systems a portion of the DSPC-cholesterol is internalised together with siRNA[2]. References [1]. Andrew D Miller. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811. [2]. Jayesh A Kulkarni, et al. On the role of helper lipids in lipid nanoparticle formulations of siRNA. Nanoscale. 2019 Nov 21;11(45):21733-21739. Chemical & Physical Properties Melting Point 236 °C Molecular Formula C44H88NO8P Molecular Weight 790.145 Exact Mass 789.624756 PSA 121.00000 LogP 13.00 InChIKey NRJAVPSFFCBXDT-HUESYALOSA-N SMILES CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC |
| Use of | 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2]. Properties Articles54 Name 1,2-distearoyl-sn-glycero-3-phosphocholine Synonym More Synonyms Biological Activity Description 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others In Vitro In empty lipid nanoparticle (LNP) systems that do not contain siRNA, DSPC-cholesterol resides in outer layers, whereas in loaded systems a portion of the DSPC-cholesterol is internalised together with siRNA[2]. References [2]. Jayesh A Kulkarni, et al. On the role of helper lipids in lipid nanoparticle formulations of siRNA. Nanoscale. 2019 Nov 21;11(45):21733-21739. Chemical & Physical Properties Molecular Formula C44H88NO8P Exact Mass 789.624756 PSA 121.00000 LogP 13.00 InChIKey NRJAVPSFFCBXDT-HUESYALOSA-N SMILES CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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