CAS Number760-78-1
SynonymsDL-NORVALINE; α-DL-Aminopentanoic acid; DL-2-Aminovaleric Acid; 2-Aminovaleric acid; MFCD00064420; DL-norVal-OH; DL-2-Aminopentanoic acid; (±)-2-Aminopentanoic acid; H-DL-Nva-OH; rac-norvaline; a-Aminovaleric Acid; 2-Aminopentanoic acid; EINECS 212-082-7; APE; DL-α-Aminovaleric acid; Norvaline; NVA; UNII:V639KTF2SZ; Norvaline (VAN); (±)-Norvaline; aminovaleric acid
Molecular FormulaCH3CH2CH2CH(NH2)COOH
Molecular Weight117.15
Purity≥98 (HPLC)%
Density1.1±0.1 g/cm3
Boiling Point222.9±23.0 °C at 760 mmHg
Melting Point>300 °C
Appearancepowder
EINECS212-082-7
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 760-78-1 |
| Catalog No. | 2A-9025099 |
| Chinese Name | DL-正缬氨酸 |
| Synonyms | DL-NORVALINE; α-DL-Aminopentanoic acid; DL-2-Aminovaleric Acid; 2-Aminovaleric acid; MFCD00064420; DL-norVal-OH; DL-2-Aminopentanoic acid; (±)-2-Aminopentanoic acid; H-DL-Nva-OH; rac-norvaline; a-Aminovaleric Acid; 2-Aminopentanoic acid; EINECS 212-082-7; APE; DL-α-Aminovaleric acid; Norvaline; NVA; UNII:V639KTF2SZ; Norvaline (VAN); (±)-Norvaline; aminovaleric acid |
| Molecular Formula | CH3CH2CH2CH(NH2)COOH |
| Molecular Weight | 117.15 |
| Purity | ≥98 (HPLC) |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 222.9±23.0 °C at 760 mmHg |
| Melting Point | >300 °C |
| Appearance | powder |
| Water Solubility | 1 g/10 mL (18 ºC) |
| Storage Condition | Keep container sealed, placed in a tight-fitting c |
| Application | DL-Norvaline is a metabolite of L-norvaline, a non-competitive inhibitor of arginase. |
| EINECS | 212-082-7 |
| HTC | 29224995 |
| PubChem ID | 24897829 |
| MDL Number | MFCD00064420 |
| SMILES | CCCC(N)C(O)=O |
| InChI | 1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8) |
| InChI Key | SNDPXSYFESPGGJ-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1721163 |
| NACRES Code | NA.26 |
| UNSPSC | 12352209 |
| MSDS | msds/25099_1_760_78_1.pdf |
| Bioactivity | DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Arginase Research Areas >> Metabolic Disease Natural Products >> Others Target Human Endogenous Metabolite In Vitro DL-Norvaline, a derivative of L-norvaline[1], L-norvaline is a non-competitive inhibitor of arginase[2]. Cell Assay A murine macrophage cell line (RAW264.7) is used throughout the study, RAW264.7 cells are induced by A. actinomycetemcomitans-lipopolysaccharide, cells are incubated with various concentrations of L-norvaline or DL-norvaline (0.01, 0.1, 1, 10 mM) and 10 μg of A. actinomycetemcomitans-lipopolysaccharide. In other experiments, cells are incubated with antimurine CD14 or antimurine toll-like receptor 2 and 4 antibody at room temperature for 1 h, washed three times, and then stimulated with 10 μg of A. actinomycetemcomitans-lipopolysaccharide. All experiments are repeated three times, each consisting of triplicate cultures[1]. References [1]. Sosroseno W, et al. Arginase activity in a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. 2006 Jun;21(3):145-50. [2]. El-Bassossy HM, et al. Arginase inhibition alleviates hypertension associated with diabetes: effect on endothelial dependent relaxation and NO production. Vascul Pharmacol. 2012 Nov-Dec;57(5-6):194-200. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 222.9±23.0 °C at 760 mmHg Melting Point ≥300 °C (dec.) Molecular Formula C5H11NO2 Molecular Weight 117.146 Flash Point 88.6±22.6 °C Exact Mass 117.078979 PSA 63.32000 LogP 0.38 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.464 InChIKey SNDPXSYFESPGGJ-UHFFFAOYSA-N SMILES CCCC(N)C(=O)O Storage condition Store at RT. Water Solubility 1 g/10 mL (18 ºC) |
| Use of | DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase. Properties Articles40 Name 2-aminopentanoic acid Synonym More Synonyms DL-Norvaline Biological Activity Description DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Arginase Research Areas >> Metabolic Disease Natural Products >> Others Human Endogenous Metabolite In Vitro DL-Norvaline, a derivative of L-norvaline[1], L-norvaline is a non-competitive inhibitor of arginase[2]. References [1]. Sosroseno W, et al. Arginase activity in a murine macrophage cell line (RAW264.7) stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. 2006 Jun;21(3):145-50. [2]. El-Bassossy HM, et al. Arginase inhibition alleviates hypertension associated with diabetes: effect on endothelial dependent relaxation and NO production. Vascul Pharmacol. 2012 Nov-Dec;57(5-6):194-200. Chemical & Physical Properties Molecular Formula C5H11NO2 Exact Mass 117.078979 PSA 63.32000 Index of Refraction 1.464 InChIKey SNDPXSYFESPGGJ-UHFFFAOYSA-N SMILES CCCC(N)C(=O)O Storage condition Store at RT. |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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