CAS Number655-05-0
Synonyms2-Dimethylamino-5-phenyl-4-oxazolinon-(4); Tozalinona [INN-Spanish]; 2-Oxazolin-4-one,2-(dimethylamino)-5-phenyl; 5-Phenyl-2-dimethylamino-2-oxazolin-4-on; 2-(Dimethylamino)-5-phenyl-2-oxazolin-4-one; 2-Dimethylamino-5-phenyl-4-oxo-2-oxazolin; 2-Dimethylamino-4-oxo-5-phenyl-oxazolin; Tozalinonum [INN-Latin]; Stimsen; 2-dimethylamino-5-phenyl-oxazol-4-one; Tozalinone; THOZALINONE
Molecular FormulaC11H12N2O2
Molecular Weight204.23
Purity98.00%
Density1.19g/cm3
Boiling Point294.8ºC at 760 mmHg
Melting Point134.5ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 655-05-0 |
| Catalog No. | 2A-9024754 |
| Chinese Name | 托扎啉酮 |
| Synonyms | 2-Dimethylamino-5-phenyl-4-oxazolinon-(4); Tozalinona [INN-Spanish]; 2-Oxazolin-4-one,2-(dimethylamino)-5-phenyl; 5-Phenyl-2-dimethylamino-2-oxazolin-4-on; 2-(Dimethylamino)-5-phenyl-2-oxazolin-4-one; 2-Dimethylamino-5-phenyl-4-oxo-2-oxazolin; 2-Dimethylamino-4-oxo-5-phenyl-oxazolin; Tozalinonum [INN-Latin]; Stimsen; 2-dimethylamino-5-phenyl-oxazol-4-one; Tozalinone; THOZALINONE |
| Molecular Formula | C11H12N2O2 |
| Molecular Weight | 204.23 |
| Purity | 98.00 |
| Density | 1.19g/cm3 |
| Boiling Point | 294.8ºC at 760 mmHg |
| Melting Point | 134.5ºC |
| Storage Condition | 2-8°C |
| Application | Thozalinone, also known as 5-phenyl-2-dimethylamino-2-oxazolin-4-one, is a stimulant with anti-tetrabenazine depressant activity. Thozalinone has unique properties that distinguish it from sympathomim |
| HTC | 2934999090 |
| MDL Number | MFCD00865449 |
| SMILES | CN(C)C1=NC(=O)C(c2ccccc2)O1 |
| InChI | InChI=1S/C11H12N2O2/c1-13(2)11-12-10(14)9(15-11)8-6-4-3-5-7-8/h3-7,9H,1-2H3 |
| InChI Key | JJSHYECKYLDYAR-UHFFFAOYSA-N |
| MSDS | msds/24754_1_655_05_0.pdf |
| Use of | Thozalinone also known as 5phenyl-2-dimethylamino-2-oxazolin-4-one, is an excitant with activity against Tetrabenazine depression. Thozalinone has unique properties distinguishing them from the sympathomimetic amines[1]. Properties Name 2-(dimethylamino)-5-phenyl-1,3-oxazol-4-one Synonym More Synonyms Thozalinone Biological Activity Description Thozalinone also known as 5phenyl-2-dimethylamino-2-oxazolin-4-one, is an excitant with activity against Tetrabenazine depression. Thozalinone has unique properties distinguishing them from the sympathomimetic amines[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Greenblatt EN, et al. Some pharmacologic properties of thozalinone, a new excitant. Toxicol Appl Pharmacol. 1965 Jul;7(4):566-78. Chemical & Physical Properties Molecular Formula C11H12N2O2 Exact Mass 204.09000 PSA 41.90000 LogP 0.63770 Index of Refraction 1.584 InChIKey JJSHYECKYLDYAR-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 2-Oxazolin-4-one, 2-(dimethylamino)-5-phenyl- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C11-H12-N2-O2 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T5NV DO CHJ CR& EN1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - ataxia Behavioral - somnolence (general depressed activity) REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965 Safety Information HS Code 2934999090 Synthetic Route CAS#:2152-34-3 Dimethylamine CAS#:124-40-3 Thozalinone CAS#:655-05-0 Literature: Howell,C.F. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 1679 - 1685 CAS#:2152-34-3 Dimethyl sulfate CAS#:77-78-1 Thozalinone CAS#:655-05-0 Literature: Howell,C.F. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 1686 - 1691 5-phenyl-2-thio... CAS#:19331-89-6 Dimethylamine CAS#:124-40-3 Thozalinone CAS#:655-05-0 Literature: Howell,C.F. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 1679 - 1685 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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