CAS Number644-62-2
Synonymsmeclofenamate; 2-(2,6-dichloro-3-methylanilino)benzoic acid; 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid; meclofenamic acid
Molecular FormulaC14H11O2N1Cl2
Molecular Weight296.15
Purity98.00%
Density1.4±0.1 g/cm3
Boiling Point399.4±42.0 °C at 760 mmHg
Melting Point257-259ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 644-62-2 |
| Catalog No. | 2A-9024709 |
| Chinese Name | 甲氯芬那酸 |
| Synonyms | meclofenamate; 2-(2,6-dichloro-3-methylanilino)benzoic acid; 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid; meclofenamic acid |
| Molecular Formula | C14H11O2N1Cl2 |
| Molecular Weight | 296.15 |
| Purity | 98.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 399.4±42.0 °C at 760 mmHg |
| Melting Point | 257-259ºC |
| Storage Condition | Refrigerator |
| Application | Meclofenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) approved for arthritis (osteoarthritis and rheumatoid arthritis), analgesia (mild to moderate pain), dysmenorrhea, and severe menstru |
| HTC | 2922499990 |
| MDL Number | MFCD00072053 |
| SMILES | Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl |
| InChI | InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19) |
| InChI Key | InChIKey=SBDNJUWAMKYJOX-UHFFFAOYSA-N |
| MSDS | msds/24709_1_644_62_2.pdf |
| Use of | Meclofenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor[1][2][3]. Properties Name meclofenamic acid Synonym More Synonyms meclofenamic acid Biological Activity Description Meclofenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor[1][2][3]. References [1]. Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8. [2]. Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017. [3]. Huang Y, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43(1):373-84. Chemical & Physical Properties Exact Mass 295.016693 PSA 49.33000 Index of Refraction 1.663 Storage condition Refrigerator Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Anthranilic acid, N-(2,6-dichloro-m-tolyl)- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C14-H11-Cl2-N-O2 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : QVR BMR BG FG C1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intrauterine SEX/DURATION : female 4 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 63,365,1981 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 38,238,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular 2750 ug/kg SEX/DURATION : female 1-3 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 14,451,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 16 week(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 65,157,1982 Safety Information HS Code 2922499990 Synthetic Route 2-(2,6-Dichloro... CAS#:3254-79-3 meclofenamic acid CAS#:644-62-2 Literature: US5462952 A1, ; US 5462952 A 2,6-dichloro-m-... CAS#:64063-37-2 2-Fluorobenzoic acid CAS#:445-29-4 meclofenamic acid CAS#:644-62-2 2,6-dichloro-m-... CAS#:64063-37-2 2-Chlorobenzoic acid CAS#:118-91-2 meclofenamic acid CAS#:644-62-2 Literature: Pellon, Rolando F.; Carrasco, Ramon; Marquez, Tania; Mamposo, Taimirys Tetrahedron Letters, 1997 , vol. 38, # 29 p. 5107 - 5110 |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | P. Quarantine of entry animals, plants, and animal and plant products Q. Quarantine of exit animals, plants, and animal and plant products R. Hygiene supervision and inspection of imported food S. Hyg |
| Transport Info | Product name: Supervision conditions A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Aceglatone | 642-83-1 | 2A-9024698 |
| 3-Methylbenzophenone | 643-65-2 | 2A-9024702 |
| Precocene II | 644-06-4 | 2A-9024705 |
| 2-Methylphenylacetic acid | 644-36-0 | 2A-9024707 |
| Propyl isobutyrate | 644-49-5 | 2A-9024708 |
| 1,6-Anhydro-beta-D-galactose | 644-76-8 | 2A-9024710 |
| (+/-)-2-Aminooctanoic acid | 644-90-6 | 2A-9024711 |
| Dichlorophenylphosphine | 644-97-3 | 2A-9024712 |
| 1-Iodo-3-nitrobenzene | 645-00-1 | 2A-9024713 |
| 5-Nitro-2-furoic acid | 645-12-5 | 2A-9024716 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS