CAS Number630-02-4
SynonymsN-o-Carbomethoxyphenyl-N'-phenylthiourea; Benzoic acid,2-[[(phenylamino)thioxomethyl]amino]-,methyl ester; EINECS 211-125-7; MFCD00009355; n-Octakosan; n-Octacosane
Molecular FormulaCH3(CH2)26CH3
Molecular Weight394.76
Purity99%
Boiling Point278 °C/15 mmHg (lit.)
Melting Point57-64 °C (lit.)
Appearancepowder
EINECS211-125-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 630-02-4 |
| Catalog No. | 2A-9024592 |
| Chinese Name | 二十八烷 |
| Synonyms | N-o-Carbomethoxyphenyl-N'-phenylthiourea; Benzoic acid,2-[[(phenylamino)thioxomethyl]amino]-,methyl ester; EINECS 211-125-7; MFCD00009355; n-Octakosan; n-Octacosane |
| Molecular Formula | CH3(CH2)26CH3 |
| Molecular Weight | 394.76 |
| Purity | 99 |
| Boiling Point | 278 °C/15 mmHg (lit.) |
| Melting Point | 57-64 °C (lit.) |
| Appearance | powder |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Packaging | II; III |
| Application | Octocadecane is an endogenous metabolite with antimicrobial activity. Octocadecane showed high cytotoxicity against mouse melanoma B16F10-Nex2 cells and in addition induced protection against transpla |
| EINECS | 211-125-7 |
| HTC | 29011090 |
| PubChem ID | 24898009 |
| MDL Number | MFCD00009355 |
| SMILES | CCCCCCCCCCCCCCCCCCCCCCCCCCCC |
| InChI | 1S/C28H58/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h3-28H2,1-2H3 |
| InChI Key | ZYURHZPYMFLWSH-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1770570 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | 4.1 |
| MSDS | msds/24592_1_630_02_4.pdf |
| Bioactivity | Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l[1][2][3]. Related Catalog Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial Target Human Endogenous Metabolite In Vitro Octacane (12.5-100 μg/ml; 18 hours) has strong cytotoxic activity against B16F10-Nex2 cells with an IC50 value of 41.08 μg/ml[1]. Cell Cytotoxicity Assay[1] Cell Line: B16F10-Nex2 cells Concentration: 12.5, 25, 50, 100 μg/ml Incubation Time: 18 h Result: Displayed strong cytotoxic activity on B16F10-Nex2 cells, with an IC50 value of 41.08 μg/ml In Vivo octadecane (500 μg; Injection at peripheral sites associated with blast cell transplantation; daily; 35 days) can significantly delay tumor progression and have significant anti-tumor effects [1]. Animal Model: C57Bl/6 mice with B16F10-Nex2 Cellsl[1] Dosage: 500 μg Administration: Injected at peripheral sites in relation to the original cell grafting; daily; 35 days Result: Resulted in a significant delay of tumor progression with a significant antitumor effect. The survival rate of treated groups was significantly increased. References [1]. Carlos R Figueiredo, et al. Pyrostegia venusta Heptane extract containing saturated aliphatic hydrocarbons induces apoptosis on B16F10-Nex2 melanoma cells and displays antitumor activity in vivo. Pharmacogn Mag. 2014 Apr;10(Suppl 2):S363-76. [2]. S Rajkumar, et al. Mosquitocidal activities of octacosane from Moschosma polystachyum Linn (lamiaceae). J Ethnopharmacol. 2004 Jan;90(1):87-9. [3]. Sameh S M Soliman, et al. Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites. PLoS One. 2020 Oct 6;15(10):e0240156. Chemical & Physical Properties Boiling Point 278 °C15 mm Hg(lit.) Melting Point 57-62 °C(lit.) Molecular Formula C28H58 Molecular Weight 394.76000 Flash Point 227 °C Exact Mass 394.45400 LogP 11.16880 Vapor density 13.6 (vs air) Vapor Pressure <1 mm Hg ( 20 °C) Index of Refraction 1.4330 (70ºC) InChIKey ZYURHZPYMFLWSH-UHFFFAOYSA-N SMILES CCCCCCCCCCCCCCCCCCCCCCCCCCCC Stability Stable. Combustible. Incompatible with strong oxidizing agents. |
| Use of | Properties Name octacosane Synonym More Synonyms n-Octacosane Biological Activity Related Catalog Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial Human Endogenous Metabolite References [2]. S Rajkumar, et al. Mosquitocidal activities of octacosane from Moschosma polystachyum Linn (lamiaceae). J Ethnopharmacol. 2004 Jan;90(1):87-9. [3]. Sameh S M Soliman, et al. Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites. PLoS One. 2020 Oct 6;15(10):e0240156. Chemical & Physical Properties Molecular Formula C28H58 Exact Mass 394.45400 LogP 11.16880 Vapour density 13.6 (vs air) Index of Refraction 1.4330 (70ºC) InChIKey ZYURHZPYMFLWSH-UHFFFAOYSA-N SMILES CCCCCCCCCCCCCCCCCCCCCCCCCCCC Stability Stable. Combustible. Incompatible with strong oxidizing agents. |
| Transport Info | Product name: Purity: 97.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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