CAS Number626-72-2
SynonymsL-Homocystine; Dl-Homocycine; (2S,2'S)-4,4'-Dithiobis(2-aminobutanoic acid); dl-homocystine crystalline; HOMOCYSTINE,DL; QVYZ2SS2YZVQ &&L-L Form; (2S,2'S)-4,4'-Disulfanediylbis(2-aminobutanoic acid); EINECS 210-962-5; H-DL-Hcys-OH)2; homocystine; (2S,2'S)-4,4'-Dithiobis(2-aminobutyric acid); MFCD00020391; DL-Homocystine; H-HoCys-OH; (H-HoCys-OH)2
Molecular FormulaC8H16N2O4S2
Molecular Weight268.35
Purity≥98 (HPLC)%
Density1.4±0.1 g/cm3
Boiling Point507.6±50.0 °C at 760 mmHg
Melting Point281-284 °C (dec.) (lit.)
Appearancepowder
EINECS210-962-5
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 626-72-2 |
| Catalog No. | 2A-9024521 |
| Chinese Name | L-高胱氨酸 |
| Synonyms | L-Homocystine; Dl-Homocycine; (2S,2'S)-4,4'-Dithiobis(2-aminobutanoic acid); dl-homocystine crystalline; HOMOCYSTINE,DL; QVYZ2SS2YZVQ &&L-L Form; (2S,2'S)-4,4'-Disulfanediylbis(2-aminobutanoic acid); EINECS 210-962-5; H-DL-Hcys-OH)2; homocystine; (2S,2'S)-4,4'-Dithiobis(2-aminobutyric acid); MFCD00020391; DL-Homocystine; H-HoCys-OH; (H-HoCys-OH)2 |
| Molecular Formula | C8H16N2O4S2 |
| Molecular Weight | 268.35 |
| Purity | ≥98 (HPLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 507.6±50.0 °C at 760 mmHg |
| Melting Point | 281-284 °C (dec.) (lit.) |
| Appearance | powder |
| Storage Condition | 0-10 save. |
| Application | L-Homocystine is an oxide of L-homocysteine. L-homocysteine is an anti-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor, and an inducer of endoplasmic reticulum stress respon |
| EINECS | 210-962-5 |
| PubChem ID | 24895724 |
| MDL Number | MFCD00020391 |
| SMILES | N[C@@H](CCSSCC[C@H](N)C(O)=O)C(O)=O |
| InChI | 1S/C8H16N2O4S2/c9-5(7(11)12)1-3-15-16-4-2-6(10)8(13)14/h5-6H,1-4,9-10H2,(H,11,12)(H,13,14)/t5-,6-/m0/s1 |
| InChI Key | ZTVZLYBCZNMWCF-WDSKDSINSA-N |
| Beilstein/REAXYS | 1728583 |
| NACRES Code | NA.26 |
| UNSPSC | 12352209 |
| Hazard Symbols | transportation |
| MSDS | msds/24521_1_626_72_2.pdf |
| Bioactivity | L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms. Related Catalog Natural Products >> Others Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Target Human Endogenous Metabolite In Vivo A single or multiple doses of L-Homocystine administered to mice during organogenesis can aggravate the developmental disturbances caused by a single dose of VPA administered on GD 8. Whereas, VPA lowers significantly plasma FA and vitamin B12 concentrations, it has no direct impact on the homocysteine concentrations. Therefore, it is proposed that high levels of homocysteine disturb the FA, vitamin B12, and possibly methionine metabolism thus providing a favorable situation for VPA to interfere with the development of susceptible embryos[1]. Animal Admin Mice[1] Groups of mice are first injected on GD 8 with a single dose of 75 mg/kg of L-Homocystine or an equal volume of saline. One half of the L-Homocystine-treated animals then receive a single dose of 600 mg/kg of VPA ((H-HoCys-OH)2+VPA group), while the other half are injected with a proportionate volume of saline (L-Homocystine+saline group). In the other experiment, mice are treated with a daily dose of 75 mg/kg of L-Homocystine or a proportionate volume of saline starting from GD 5 and continue through GD 10. One half of the L-Homocystine-treated animals also have a single exposure to 600 mg/kg of VPA (L-Homocystine+VPA group) or a proportionate volume of saline (L-Homocystine+saline group) on GD 8. The total volume of fluid injected corresponded to the body weight and does not exceed 0.45 mL[1]. References [1]. Padmanabhan R, et al. Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos. Eur J Nutr. 2006 Sep;45(6):311-9 Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 507.6±50.0 °C at 760 mmHg Melting Point 281-284ºC (dec.) Molecular Formula C8H16N2O4S2 Molecular Weight 268.354 Flash Point 260.8±30.1 °C Exact Mass 268.055145 PSA 177.24000 LogP 1.03 Vapour Pressure 0.0±2.8 mmHg at 25°C Index of Refraction 1.619 InChIKey ZTVZLYBCZNMWCF-WDSKDSINSA-N SMILES NC(CCSSCCC(N)C(=O)O)C(=O)O Storage condition 2~8°C |
| Use of | L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms. Properties Name L-Homocystine Synonym More Synonyms L-Homocystine Biological Activity Description L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms. Related Catalog Natural Products >> Others Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Human Endogenous Metabolite References [1]. Padmanabhan R, et al. Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos. Eur J Nutr. 2006 Sep;45(6):311-9 Chemical & Physical Properties Molecular Formula C8H16N2O4S2 Exact Mass 268.055145 PSA 177.24000 Index of Refraction 1.619 InChIKey ZTVZLYBCZNMWCF-WDSKDSINSA-N SMILES NC(CCSSCCC(N)C(=O)O)C(=O)O |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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