| Chemical & Physical Properties | |
|---|---|
| CAS Number | 621-72-7 |
| Catalog No. | 2A-9024371 |
| Chinese Name | 地巴唑 |
| Synonyms | EINECS 210-703-6; bendazol; 2-benzylbenzIMIDAZOLE; MFCD00022680; 2-Benzyl-1H-benzimidazole; bendazole |
| Molecular Formula | C14H12N2 |
| Molecular Weight | 208.26 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 453.5±24.0 °C at 760 mmHg |
| Melting Point | 187ºC |
| Storage Condition | Ventilated, low-temperature drying, stored separat |
| Application | Bendazol is an antihypertensive drug that also enhances the activity of NO synthase in glomeruli and collecting tubules. |
| HTC | 2942000000 |
| MDL Number | MFCD00022680 |
| SMILES | c1ccc(Cc2nc3ccccc3[nH]2)cc1 |
| InChI Key | YTLQFZVCLXFFRK-UHFFFAOYSA-N |
| MSDS | msds/24371_1_621_72_7.pdf |
| Use of | Bendazol is a hypotensive drug which can also enhance NO synthase activity in renal glomeruli and collecting tubules. Properties Name 2-Benzyl-1H-benzimidazole Synonym More Synonyms bendazol Biological Activity Description Bendazol is a hypotensive drug which can also enhance NO synthase activity in renal glomeruli and collecting tubules. Related Catalog Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Cardiovascular Disease NO synthase[1] References [1]. Eliseeva EV, et al. Effect of Hypotensive Drugs on Dynamics of Nitroxide-Producing Renal Function in Rats with Nephrogenic Hypertension. Bull Exp Biol Med. 2017 Jan;162(3):357-361. Chemical & Physical Properties Molecular Formula C14H12N2 Exact Mass 208.100052 PSA 28.68000 Index of Refraction 1.680 InChIKey YTLQFZVCLXFFRK-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Benzimidazole, 2-benzyl- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C14-H12-N2 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T56 BM DNJ C1R HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.3- 1930- Volume(issue)/page/year: (1),44,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 24(6),25,1990 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 13,829,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 64400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2292473 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.3- 1930- Volume(issue)/page/year: (5),26,1983 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REFERENCE : AKGIAO Akushcherstvo i Ginekologiya (Moscow). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1936- Volume(issue)/page/year: 43(12),10,1967 Safety Information Hazard Codes Xi HS Code 2942000000 Synthetic Route Phenylacetaldeh... o-Phenylenediam... Literature: Adharvana Chari, Murugulla; Shobha, Donthabhakthuni; Sasaki, Takehiko Tetrahedron Letters, 2011 , vol. 52, # 43 p. 5575 - 5580 2-Phenylethanam... o-Phenylenediam... Literature: Pizzetti, Marianna; De Luca, Elisa; Petricci, Elena; Taddei, Maurizio; Porcheddu, Andrea Advanced Synthesis and Catalysis, 2012 , vol. 354, # 13 p. 2453 - 2464,12 Title/Abstract Full Text Show Details Pizzetti, Marianna; De Luca, Elisa; Petricci, Elena; Porcheddu, Andrea; Taddei, Maurizio Advanced Synthesis and Catalysis, 2012 , vol. 354, # 13 p. 2453 - 2464 Phenylessigsaeu... Literature: Xing, Rui-Guang; Li, Ya-Nan; Liu, Qiang; Meng, Qing-Yuan; Li, Jing; Shen, Xiao-Xia; Liu, Zhengang; Zhou, Bo; Yao, Xiaojun; Liu, Zhong-Li European Journal of Organic Chemistry, 2010 , # 34 p. 6627 - 6632 Precursor & DownStream Precursor 10 CAS#:122-78-1 Phenylacetaldehyde CAS#:95-54-5 o-Phenylenediamine CAS#:64-04-0 2-Phenylethanamine CAS#:1504-26-3 Phenylessigsaeu... DownStream 7 CAS#:152342-26-2 2-(3-METHYL-1,2... CAS#:7189-72-2 2-benzyl-6-nitr... CAS#:78465-92-6 2-benzyl-1,3-di... CAS#:955-41-9 Methanone,1H-be... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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