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2-Amino-5-bromo-4-hydroxy-6-phenylpyrimidine(2-Amino-5-bromo-6-phenylpyrimidin-4-ol)

Name: 2-Amino-5-bromo-4-hydroxy-6-phenylpyrimidine(2-Amino-5-bromo-6-phenylpyrimidin-4-ol)
Brand: 2A Biotech
SKU: 2A-9002357

CAS Number56741-95-8

Synonyms2-Amino-5-bromo-6-phenyl-4(1H)-pyrimidinone; 2-Amino-5-bromo-6-phenylpyrimidin-4(1H)-one; Bropirimine; 2-Amino-5-bromo-6-phenylpyrimidin-4-ol; ABPP; 2-amino-5-bromo-6-phenyl-1H-pyrimidin-4-one

Molecular FormulaC10H8BrN3O

Molecular Weight266.094

Purity98%

Density1.7±0.1 g/cm3

Boiling Point473.2±55.0 °C at 760 mmHg

MSDSChinese English

Symbol

Signal WordWarning

Cat. No.: 2A-9002357 Purity: 98%

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Quality Control of [ 56741-95-8 ] Purity: 98% SDS Specification MoL

Chemical & Physical Properties
CAS Number	56741-95-8
Catalog No.	2A-9002357
Chinese Name	溴匹立明
Synonyms	2-Amino-5-bromo-6-phenyl-4(1H)-pyrimidinone; 2-Amino-5-bromo-6-phenylpyrimidin-4(1H)-one; Bropirimine; 2-Amino-5-bromo-6-phenylpyrimidin-4-ol; ABPP; 2-amino-5-bromo-6-phenyl-1H-pyrimidin-4-one
Molecular Formula	C10H8BrN3O
Molecular Weight	266.094
Purity	98
Density	1.7±0.1 g/cm3
Boiling Point	473.2±55.0 °C at 760 mmHg
Storage Condition	Warehouse Ventilation Low Temperature Drying
Application	Bropirimine is a synthetic agonist of toll-like receptor 7 (TLR7). Bropirimine inhibits the differentiation of osteoclast precursor cells into osteoclasts through TLR7-mediated IFN-β production. Bropi
HTC	2933599090
SMILES	Nc1nc(-c2ccccc2)c(Br)c(=O)[nH]1
InChI	InChI=1S/C10H8BrN3O/c11-7-8(6-4-2-1-3-5-6)13-10(12)14-9(7)15/h1-5H,(H3,12,13,14,15)
InChI Key	CIUUIPMOFZIWIZ-UHFFFAOYSA-N
Hazard Symbols	Transport
MSDS	msds/2357_1_56741_95_8.pdf
Bioactivity	Bropirimine is a synthetic agonist for toll-like receptor 7 (TLR7). Bropirimine inhibits differentiation of osteoclast precursor cells into osteoclasts via TLR7-mediated production of IFN-β. Bropirimine is an orally active immunomodulator that has demonstrated anticancer activity in transitional cell carcinoma in situ (CIS) in both the bladder and upper urinary tract[1][2]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Cancer References [1]. Suzuki H, et al. Bropirimine inhibits osteoclast differentiation through production of interferon-β. Biochem Biophys Res Commun. 2015;467(1):146‐151. [2]. Sarosdy MF, et al. Oral bropirimine immunotherapy of bladder carcinoma in situ after prior intravesical bacille Calmette-Guérin. Urology. 1998;51(2):226‐231. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 473.2±55.0 °C at 760 mmHg Molecular Formula C10H8BrN3O Molecular Weight 266.094 Flash Point 240.0±31.5 °C Exact Mass 264.985077 PSA 72.03000 LogP 1.90 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.696 InChIKey CIUUIPMOFZIWIZ-UHFFFAOYSA-N SMILES Nc1nc(-c2ccccc2)c(Br)c(=O)[nH]1
Use of	Bropirimine is a synthetic agonist for toll-like receptor 7 (TLR7). Bropirimine inhibits differentiation of osteoclast precursor cells into osteoclasts via TLR7-mediated production of IFN-β. Bropirimine is an orally active immunomodulator that has demonstrated anticancer activity in transitional cell carcinoma in situ (CIS) in both the bladder and upper urinary tract[1][2]. Properties Articles28 Name 2-Amino-5-bromo-4-hydroxy-6-phenylpyrimidine Synonym More Synonyms Bropirimine Biological Activity Description Bropirimine is a synthetic agonist for toll-like receptor 7 (TLR7). Bropirimine inhibits differentiation of osteoclast precursor cells into osteoclasts via TLR7-mediated production of IFN-β. Bropirimine is an orally active immunomodulator that has demonstrated anticancer activity in transitional cell carcinoma in situ (CIS) in both the bladder and upper urinary tract[1][2]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Cancer References [1]. Suzuki H, et al. Bropirimine inhibits osteoclast differentiation through production of interferon-β. Biochem Biophys Res Commun. 2015;467(1):146‐151. [2]. Sarosdy MF, et al. Oral bropirimine immunotherapy of bladder carcinoma in situ after prior intravesical bacille Calmette-Guérin. Urology. 1998;51(2):226‐231. Chemical & Physical Properties Molecular Formula C10H8BrN3O Exact Mass 264.985077 PSA 72.03000 Index of Refraction 1.696 InChIKey CIUUIPMOFZIWIZ-UHFFFAOYSA-N
Tax Rebate	13.0%
Supervision	None. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport Info	Product name: Purity: 98.0%
MSDS Transport Info	Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available

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2-Amino-5-bromo-4-hydroxy-6-phenylpyrimidine(2-Amino-5-bromo-6-phenylpyrimidin-4-ol)

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