CAS Number573-58-0
SynonymsDIRECT RED 28; Solucongo; Hemorrhagyl; sodium salt of benzidinediazobis-1-naphthylamine-4-sulfonic acid; Congo red; Haemomedical; benzidinediazo-bis-1-naphtylamine-4 sulfonic acid disodium; EINECS 209-358-4; Congazone sodium; MFCD00004028; Haemonorm; Benzo Congo Red
Molecular FormulaC32H22N6Na2O6S2
Molecular Weight696.66
Purity98.00%
Density0.995 g/mL at 25 °C
Melting Point>360 °C (lit.)
Appearancepowder
EINECS209-358-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 573-58-0 |
| Catalog No. | 2A-9022988 |
| Chinese Name | 刚果红 |
| Synonyms | DIRECT RED 28; Solucongo; Hemorrhagyl; sodium salt of benzidinediazobis-1-naphthylamine-4-sulfonic acid; Congo red; Haemomedical; benzidinediazo-bis-1-naphtylamine-4 sulfonic acid disodium; EINECS 209-358-4; Congazone sodium; MFCD00004028; Haemonorm; Benzo Congo Red |
| Molecular Formula | C32H22N6Na2O6S2 |
| Molecular Weight | 696.66 |
| Purity | 98.00 |
| Density | 0.995 g/mL at 25 °C |
| Melting Point | >360 °C (lit.) |
| Appearance | powder |
| Water Solubility | soluble |
| Storage Condition | Store in a cool, dry place. |
| Application | Congo red is an azo dye. Congo red binding has been widely used for the determination of amyloid in tissue sections. |
| EINECS | 209-358-4 |
| PubChem ID | 24892892 |
| MDL Number | MFCD00004028 |
| SMILES | [Na+].[Na+].Nc1c(cc(c2ccccc12)S([O-])(=O)=O)\N=N\c3ccc(cc3)-c4ccc(cc4)\N=N\c5cc(c6ccccc6c5N)S([O-])(=O)=O |
| InChI | 1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2/b37-35+,38-36+;; |
| InChI Key | IQFVPQOLBLOTPF-HKXUKFGYSA-L |
| Beilstein/REAXYS | 3894858 |
| NACRES Code | NA.47 |
| UNSPSC | 12171500 |
| Hazard Symbols | 6.1 |
| MSDS | msds/22988_1_573_58_0.pdf |
| Bioactivity | Congo red is an azo dye. Congo red (CR) binding been used as a diagnostic test for the presence of amyloid in tissue sections. Related Catalog Signaling Pathways >> Others >> Others Dye Reagents Research Areas >> Others In Vitro Congo red histochemical stain may serve as a simple screening tool for investigating if the aggregates in mutant cells have misfolded β-pleated sheet secondary structures. Congo red histochemical dye has the ability to bind specifically to crossed β-pleated sheet structures. Wild-type HSPB1 should maintain protein homeostasis by binding proteins in non-native conformations, thereby preventing substrate aggregation. The T139M mutant, however, fails in this function and results in an accumulation of misfolded proteins, which are targeted by Congo red for intercalating between the β-pleated sheet structures. Congo red histochemical stain may serve as a simple tool to investigate if the aggregates in mutant cells have misfolded β-pleated sheet secondary structures[1]. Cell Assay HeLa cells are selected for these studies due to their large cytoplasmic volume. Cells transfected with mutant or wild-type HSPB1 constructs are grown on coverslips for 24 hr and then are stained with Congo red to determine if the aggregates display amyloidogenic properties. Briefly, cells are first fixed with 10% formalin for 10 min and stained with 1% Congo red for 5 min, followed by destaining with 0.01% potassium hydroxide in 50% ethanol. Coverslips are then passed through graded ethanol concentrations for dehydration and mounted in a mounting medium and examined by fluorescent microscopy under rhodamine filter[1]. References [1]. Amornvit J, et al. A novel p.T139M mutation in HSPB1 highlighting the phenotypic spectrum in a family. Brain Behav. 2017 Jul 21;7(8):e00774. Chemical & Physical Properties Density 0.995 g/mL at 25 °C Melting Point >360 °C(lit.) Molecular Formula C32H22N6Na2O6S2 Molecular Weight 696.663 Exact Mass 696.083740 PSA 232.64000 LogP 10.78740 Storage condition Flammables area Water Solubility soluble |
| Use of | Congo red is an azo dye. Congo red (CR) binding been used as a diagnostic test for the presence of amyloid in tissue sections. Properties Articles52 Name Congo Red Synonym More Synonyms Congo Red Biological Activity Description Congo red is an azo dye. Congo red (CR) binding been used as a diagnostic test for the presence of amyloid in tissue sections. Related Catalog Signaling Pathways >> Others >> Others Dye Reagents Research Areas >> Others References [1]. Amornvit J, et al. A novel p.T139M mutation in HSPB1 highlighting the phenotypic spectrum in a family. Brain Behav. 2017 Jul 21;7(8):e00774. Chemical & Physical Properties Molecular Formula C32H22N6Na2O6S2 Exact Mass 696.083740 PSA 232.64000 LogP 10.78740 Storage condition Flammables area Water Solubility soluble |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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