CAS Number536-43-6
Synonyms1-Propanone, 1-(4-butoxyphenyl)-3-(1-piperidinyl)-, hydrochloride (1:1); 1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone hydrochloride (1:1); 4-n-Butoxy-β-(1-piperidyl)propiophenone hydrochloride; Tanaclone; 1-(2-(4-Butoxybenzoyl)ethyl)piperidine Hydrochloride; MFCD00035386; 4'-BUTOXY-3-PIPERIDINOPROPIOPHENONE HYDROCHLORIDE; 1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone Hydrochloride; 4-n-Butoxy-b-(1-piperidyl)propiophenone Hydrochloride; 1-Propanone, 1- (4-butoxyphenyl)-3-(1-piperidinyl)-, hydrochloride; Dyclone; Dyclonine hydrochloride; EINECS 208-633-6; 1-(4-butoxyphenyl)-3-piperidin-1-ylpropan-1-one,hydrochloride; 1-(4-Butoxyphenyl)-3-(piperidin-1-yl)propan-1-one hydrochloride (1:1); Dyclocaine hydrochloride; dyclonine hcl; Piperidine, 1-[2-(4-butoxybenzoyl)ethyl], hydrochloride; D
Molecular FormulaC18H28ClNO2
Molecular Weight325.87
Purity98.00%
Boiling Point424.5ºC at 760 mmHg
Melting Point175-176°C
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 536-43-6 |
| Catalog No. | 2A-9022677 |
| Chinese Name | 盐酸达克罗宁 |
| Synonyms | 1-Propanone, 1-(4-butoxyphenyl)-3-(1-piperidinyl)-, hydrochloride (1:1); 1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone hydrochloride (1:1); 4-n-Butoxy-β-(1-piperidyl)propiophenone hydrochloride; Tanaclone; 1-(2-(4-Butoxybenzoyl)ethyl)piperidine Hydrochloride; MFCD00035386; 4'-BUTOXY-3-PIPERIDINOPROPIOPHENONE HYDROCHLORIDE; 1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone Hydrochloride; 4-n-Butoxy-b-(1-piperidyl)propiophenone Hydrochloride; 1-Propanone, 1- (4-butoxyphenyl)-3-(1-piperidinyl)-, hydrochloride; Dyclone; Dyclonine hydrochloride; EINECS 208-633-6; 1-(4-butoxyphenyl)-3-piperidin-1-ylpropan-1-one,hydrochloride; 1-(4-Butoxyphenyl)-3-(piperidin-1-yl)propan-1-one hydrochloride (1:1); Dyclocaine hydrochloride; dyclonine hcl; Piperidine, 1-[2-(4-butoxybenzoyl)ethyl], hydrochloride; D |
| Molecular Formula | C18H28ClNO2 |
| Molecular Weight | 325.87 |
| Purity | 98.00 |
| Boiling Point | 424.5ºC at 760 mmHg |
| Melting Point | 175-176°C |
| Storage Condition | Store in a cool, dry, well-ventilated warehouse. K |
| Packaging | III |
| Application | Dyclonine is the active ingredient in throat lozenges. |
| HTC | 2942000000 |
| PubChem ID | 329749694 |
| MDL Number | MFCD00035386 |
| SMILES | Cl.CCCCOc1ccc(cc1)C(=O)CCN2CCCCC2 |
| InChI | 1S/C18H27NO2.ClH/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19;/h7-10H,2-6,11-15H2,1H3;1H |
| InChI Key | KNZADIMHVBBPOA-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/22677_1_536_43_6.pdf |
| Bioactivity | Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge.Target: Sodium ChannelDyclonine is an oral anaesthetic that is the active ingredient of Sucrets, an over the counter throat lozenge. It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt. Dyclonine hydrochloride has been found to possess, in addition to its topical anesthetic properties, significant bactericidal and fungicidal activity. Self-sterilizing action manifested by preparations containing the drug was considerably enhanced upon the addition of chlorobutanol. Results of in vitro tests employing microorganisms commonly involved in local infections indicated that the two agents in combination act synergistically [1, 2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease References [1]. Florestano, H.J. and M.E. Bahler, Antimicrobial properties of dyclonine hydrochloride, a new topical anesthetic. J Am Pharm Assoc Am Pharm Assoc (Baltim), 1956. 45(5): p. 320-5. [2]. Gargiulo, A.V., G.M. Burns, and C.P. Huck, Dyclonine hydrochloride--a topical agent for managing pain. Ill Dent J, 1992. 61(4): p. 303-4. Chemical & Physical Properties Boiling Point 424.5ºC at 760 mmHg Melting Point 175-176°C Molecular Formula C18H28ClNO2 Molecular Weight 325.873 Flash Point 210.5ºC Exact Mass 325.180847 PSA 29.54000 LogP 4.66410 InChIKey KNZADIMHVBBPOA-UHFFFAOYSA-N SMILES CCCCOc1ccc(C(=O)CCN2CCCCC2)cc1.Cl |
| Use of | Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge.Target: Sodium ChannelDyclonine is an oral anaesthetic that is the active ingredient of Sucrets, an over the counter throat lozenge. It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt. Dyclonine hydrochloride has been found to possess, in addition to its topical anesthetic properties, significant bactericidal and fungicidal activity. Self-sterilizing action manifested by preparations containing the drug was considerably enhanced upon the addition of chlorobutanol. Results of in vitro tests employing microorganisms commonly involved in local infections indicated that the two agents in combination act synergistically [1, 2]. Properties Name dyclonine hydrochloride Synonym More Synonyms Dyclonine hydrochloride Biological Activity Description Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge.Target: Sodium ChannelDyclonine is an oral anaesthetic that is the active ingredient of Sucrets, an over the counter throat lozenge. It is also found in some varieties of the Cepacol sore throat spray. It is a local anesthetic, used topically as the hydrochloride salt. Dyclonine hydrochloride has been found to possess, in addition to its topical anesthetic properties, significant bactericidal and fungicidal activity. Self-sterilizing action manifested by preparations containing the drug was considerably enhanced upon the addition of chlorobutanol. Results of in vitro tests employing microorganisms commonly involved in local infections indicated that the two agents in combination act synergistically [1, 2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease References [1]. Florestano, H.J. and M.E. Bahler, Antimicrobial properties of dyclonine hydrochloride, a new topical anesthetic. J Am Pharm Assoc Am Pharm Assoc (Baltim), 1956. 45(5): p. 320-5. [2]. Gargiulo, A.V., G.M. Burns, and C.P. Huck, Dyclonine hydrochloride--a topical agent for managing pain. Ill Dent J, 1992. 61(4): p. 303-4. Chemical & Physical Properties Exact Mass 325.180847 PSA 29.54000 LogP 4.66410 InChIKey KNZADIMHVBBPOA-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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