CAS Number531-55-5
SynonymsTrimethylthionine chloride; N,N-Dimethyl-7-(methylamino)-3H-phenothiazin-3-iminium chloride; Methyleneazure; 3-Methylamino-7-dimethylaminophenazathonium Chloride; N,N,N'-Trimethylthionin; EINECS 208-511-2; 3-(Dimethylamino)-7-(methylamino)phenothiazin-5-ium chloride; Methanaminium, N-methyl-N-[7-(methylamino)-3H-phenothiazin-3-ylidene]-, chloride (1:1); Trimethyldiaminophenazathonium Chloride; Azure B eosinate; Azure B,Certified; Azure I; Phenothiazinium, 3-(dimethylamino)-7-(methylamino)-, chloride (1:1); Phenothiazin-5-ium, 3- (dimethylamino)-7-(methylamino)-, chloride; MFCD00011935; AZUR I; dimethyl-[7-(methylamino)phenothiazin-3-ylidene]azanium,chloride; Azure B
Molecular FormulaC15H16ClN3S
Molecular Weight305.83
Purity98.00%
Melting Point205-210 °C (dec.) (lit.)
Appearancepowder
EINECS208-511-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 531-55-5 |
| Catalog No. | 2A-9022568 |
| Chinese Name | 天青B |
| Synonyms | Trimethylthionine chloride; N,N-Dimethyl-7-(methylamino)-3H-phenothiazin-3-iminium chloride; Methyleneazure; 3-Methylamino-7-dimethylaminophenazathonium Chloride; N,N,N'-Trimethylthionin; EINECS 208-511-2; 3-(Dimethylamino)-7-(methylamino)phenothiazin-5-ium chloride; Methanaminium, N-methyl-N-[7-(methylamino)-3H-phenothiazin-3-ylidene]-, chloride (1:1); Trimethyldiaminophenazathonium Chloride; Azure B eosinate; Azure B,Certified; Azure I; Phenothiazinium, 3-(dimethylamino)-7-(methylamino)-, chloride (1:1); Phenothiazin-5-ium, 3- (dimethylamino)-7-(methylamino)-, chloride; MFCD00011935; AZUR I; dimethyl-[7-(methylamino)phenothiazin-3-ylidene]azanium,chloride; Azure B |
| Molecular Formula | C15H16ClN3S |
| Molecular Weight | 305.83 |
| Purity | 98.00 |
| Melting Point | 205-210 °C (dec.) (lit.) |
| Appearance | powder |
| Water Solubility | Soluble |
| Storage Condition | This product should be kept sealed and dry. |
| Application | Azure B is a cationic dye, the main metabolite of Methylene blue, used in Azure eosin stain for blood smear staining. Azure B is a highly efficient, selective and reversible inhibitor of monoamine oxi |
| EINECS | 208-511-2 |
| HTC | 2934300000 |
| PubChem ID | 24890740 |
| MDL Number | MFCD00011935 |
| SMILES | C[N+](C)=C(C=C1)C=C(C1=N2)SC3=C2C=CC(NC)=C3.[Cl-] |
| InChI | 1S/C15H15N3S.ClH/c1-16-10-4-6-12-14(8-10)19-15-9-11(18(2)3)5-7-13(15)17-12;/h4-9H,1-3H3;1H |
| InChI Key | DNDJEIWCTMMZBX-UHFFFAOYSA-N |
| Beilstein/REAXYS | 3922630 |
| NACRES Code | NA.47 |
| UNSPSC | 12171500 |
| Hazard Symbols | Transport |
| MSDS | msds/22568_1_531_55_5.pdf |
| Bioactivity | Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects[1][2]. Related Catalog Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease In Vivo Azure B (4-30 mg/kg; i.p.; once) decreases immobility in the forced swim test (FST)[1]. References [1]. Löhr W,et al. The azure dyes: their purification and physicochemical properties. II. Purification of azure B. Stain Technol. 1975 May;50(3):149-56. [2]. Delport A, et al. Azure B and a synthetic structural analogue of methylene blue, ethylthioninium chloride, present with antidepressant-like properties. Life Sci. 2014 Nov 11;117(2):56-66. Chemical & Physical Properties Melting Point 205-210 °C (dec.)(lit.) Molecular Formula C15H16ClN3S Molecular Weight 305.826 Exact Mass 305.075348 PSA 56.17000 InChIKey DNDJEIWCTMMZBX-UHFFFAOYSA-N SMILES CNc1ccc2nc3ccc(=[N+](C)C)cc-3sc2c1.[Cl-] |
| Use of | Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects[1][2]. Properties Articles33 Name azure B Synonym More Synonyms Trimethyldiaminophenazathonium Chloride Biological Activity Description Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects[1][2]. Related Catalog Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease References [1]. Löhr W,et al. The azure dyes: their purification and physicochemical properties. II. Purification of azure B. Stain Technol. 1975 May;50(3):149-56. [2]. Delport A, et al. Azure B and a synthetic structural analogue of methylene blue, ethylthioninium chloride, present with antidepressant-like properties. Life Sci. 2014 Nov 11;117(2):56-66. Chemical & Physical Properties Exact Mass 305.075348 PSA 56.17000 InChIKey DNDJEIWCTMMZBX-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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