CAS Number518-17-2
SynonymsEVODIAMINE PLANT EXTRACT; Evodia rutaecarpa E.P.; d-Evodiamine; (13bS)-14-Methyl-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one; MFCD06407824
Molecular FormulaC19H17N3O
Molecular Weight303.36
Purity98.00%
Density1.4±0.1 g/cm3
Boiling Point575.1±50.0 °C at 760 mmHg
Melting Point263 - 265ºC
Appearancefine powder color
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 518-17-2 |
| Catalog No. | 2A-9022448 |
| Chinese Name | 吴茱萸碱 |
| Synonyms | EVODIAMINE PLANT EXTRACT; Evodia rutaecarpa E.P.; d-Evodiamine; (13bS)-14-Methyl-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one; MFCD06407824 |
| Molecular Formula | C19H17N3O |
| Molecular Weight | 303.36 |
| Purity | 98.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 575.1±50.0 °C at 760 mmHg |
| Melting Point | 263 - 265ºC |
| Appearance | fine powder color |
| Storage Condition | Store in a cool, dry, well-ventilated warehouse. K |
| Application | Evodiamine is an alkaloid isolated from the fruit of Hemerocallis fulva and has a variety of biological activities, such as anti-inflammatory, anti-obesity and anti-tumor. |
| HTC | 2933990090 |
| MDL Number | MFCD06407824 |
| SMILES | [H][C@@]1(N(C)C2=C3C=CC=C2)C4=C(C(C=CC=C5)=C5N4)CCN1C3=O |
| InChI | 1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3/t18-/m0/s1 |
| InChI Key | TXDUTHBFYKGSAH-SFHVURJKSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 12352116 |
| Hazard Symbols | 6.1 |
| MSDS | msds/22448_1_518_17_2.pdf |
| Use of | Evodiamine is an alkaloid isolated from the fruit of Evodia rutaecarpa Bentham with diverse biological activities including anti-inflammatory, anti-obesity, and antitumor. Properties Name Evodiamine Synonym More Synonyms Evodiamine Biological Activity Description Evodiamine is an alkaloid isolated from the fruit of Evodia rutaecarpa Bentham with diverse biological activities including anti-inflammatory, anti-obesity, and antitumor. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Alkaloid In Vitro Evodiamine shows cytotoxicity against a variety of human cancer cell-lines by inducing apoptosis. Moreover, it is a naturally multi-targeting antitumor molecule, which exerts the antitumor activity by various molecular mechanism such as caspase-dependent and -independent pathways, sphingomyelin pathway, calcium/JNK signaling, 31 PI3K/Akt/caspase and Fas-L/NF-κB signaling pathways32[1]. Cell Assay Evodiamine is dissolved in DMSO and diluted with appropriate medium before use. The evodiamine-inspired new scaffolds are assayed for growth inhibitory activities toward human cancer cell-lines A549 (lung cancer), MDA-MB-435 (breast cancer) and HCT116 (colon cancer) using the MTT assay. Evodiamine and camptithecin are used as reference drugs[1]. References [1]. Wang S, et al. Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents. J Med Chem. 2015 Aug 27;58(16):6678-96. [2]. Li RF,et al. Effects of Evodiamine on the Pharmacokinetics of Dapoxetine and Its Metabolite Desmethyl Dapoxetine inRats. Pharmacology. 2016;97(1-2):43-7. [3]. Shi L, et al. Evodiamine exerts anti-tumor effects against hepatocellular carcinoma through inhibiting β-catenin-mediated angiogenesis. Tumour Biol. 2016 Sep;37(9):12791-12803. Chemical & Physical Properties Molecular Formula C19H17N3O Exact Mass 303.137177 PSA 39.34000 Index of Refraction 1.764 InChIKey TXDUTHBFYKGSAH-SFHVURJKSA-N Safety Information Hazard Codes T Risk Phrases R25 Safety Phrases S45 Hazard Class 6.1 HS Code 2933990090 Synthetic Route 3H-PYRIDO(3,4-B... N-Methylisatoic... 10328-92-4 Evodiamine Literature: Tetrahedron, , vol. 67, # 31 p. 5564 - 5571 N-(2-(1H-indol-... 95274-61-6 Evodiamine Literature: Journal of Organic Chemistry, , vol. 50, # 8 p. 1246 - 1255 tryptamine Evodiamine Literature: Journal of Organic Chemistry, , vol. 50, # 8 p. 1246 - 1255 Precursor & DownStream Precursor 6 CAS#:4894-26-2 3H-PYRIDO(3,4-B... CAS#:10328-92-4 N-Methylisatoic... CAS#:61-54-1 tryptamine CAS#:118-48-9 Isatoic anhydride DownStream 1 CAS#:119-68-6 N-Methylanthran... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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